Gastroenterology
Volume 135, Issue 6 , Pages 1907-1913 , December 2008

Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and Adults

  • Michael D. Kappelman

      Affiliations

    • Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    • Corresponding Author InformationAddress requests for reprints to: Michael D. Kappelman, MD, MPH, Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Campus Box 7229, Chapel Hill, North Carolina 27599. fax: (919) 966-8641
  • ,
  • Sheryl L. Rifas–Shiman

      Affiliations

    • Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Care, Boston, Massachusetts
  • ,
  • Carol Q. Porter

      Affiliations

    • Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  • ,
  • Daniel A. Ollendorf

      Affiliations

    • Institute for Clinical and Economic Review, Boston, Massachusetts
  • ,
  • Robert S. Sandler

      Affiliations

    • Division of Gastroenterology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  • ,
  • Joseph A. Galanko

      Affiliations

    • Division of Gastroenterology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  • ,
  • Jonathan A. Finkelstein

      Affiliations

    • Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Care, Boston, Massachusetts

Received 30 April 2008 ,Accepted 4 September 2008.

References 

  1. Catlin A, Cowan C, Heffler S, et al. National health spending in 2005: the slowdown continues. Health Aff (Millwood). 2007;26:142–153
  2. Thorpe KE. Factors accounting for the rise in health-care spending in the United States: the role of rising disease prevalence and treatment intensity. Public Health. 2006;120:1002–1007
  3. Thorpe KE. The rise in health care spending and what to do about it. Health Aff (Millwood). 2005;24:1436–1445
  4. Thorpe KE, Florence CS, Howard DH, et al. The rising prevalence of treated disease: effects on private health insurance spending. Health Aff (Millwood). 2005;(Suppl):W5-317-W5-25
  5. DeVol R, Bedroussian A, Charuworn A. An unhealthy America: the economic burden of chronic disease. Santa Monica, CA: Milken Institute; 2007;
  6. Longobardi T, Jacobs P, Bernstein CN. Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey. Am J Gastroenterol. 2003;98:1064–1072
  7. Cohen RD. The quality of life in patients with Crohn's disease. Aliment Pharmacol Ther. 2002;16:1603–1609
  8. McLeod RS, Churchill DN, Lock AM, et al. Quality of life of patients with ulcerative colitis preoperatively and postoperatively. Gastroenterology. 1991;101:1307–1313
  9. Loftus EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504–1517
  10. Loftus EV. The burden of inflammatory bowel disease in the United States: a moving target?. Clin Gastroenterol Hepatol. 2007;5:1383–1384
  11. Kappelman MD, Rifas-Shiman SL, Kleinman K, et al. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007;5:1424–1429
  12. Hay JW, Hay AR. Inflammatory bowel disease: costs-of-illness. J Clin Gastroenterol. 1992;14:309–317
  13. Feagan BG, Vreeland MG, Larson LR, et al. Annual cost of care for Crohn's disease: a payor perspective. Am J Gastroenterol. 2000;95:1955–1960
  14. Lichtenstein GR, Yan S, Bala M, et al. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease. Gastroenterology. 2005;128:862–869
  15. Odes S, Vardi H, Friger M, et al. Cost analysis and cost determinants in a European inflammatory bowel disease inception cohort with 10 years of follow-up evaluation. Gastroenterology. 2006;131:719–728
  16. Druss BG, Marcus SC, Olfson M, et al. Comparing the national economic burden of five chronic conditions. Health Aff (Millwood). 2001;20:233–241
  17. Stempel DA, Mauskopf J, McLaughlin T, et al. Comparison of asthma costs in patients starting fluticasone propionate compared to patients starting montelukast. Respir Med. 2001;95:227–234
  18. Bassi A, Dodd S, Williamson P, et al. Cost of illness of inflammatory bowel disease in the UK: a single centre retrospective study. Gut. 2004;53:1471–1478
  19. Hait E, Bousvaros A, Grand R. Pediatric inflammatory bowel disease: what children can teach adults. Inflamm Bowel Dis. 2005;11:519–527
  20. Haller CA, Markowitz J. IBD in children: lessons for adults. Curr Gastroenterol Rep. 2007;9:528–532
  21. Herrinton LJ, Liu L, Lafata JE, et al. Estimation of the period prevalence of inflammatory bowel disease among nine health plans using computerized diagnoses and outpatient pharmacy dispensings. Inflamm Bowel Dis. 2007;13:451–461
  22. Bernstein CN, Blanchard JF, Rawsthorne P, et al. Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study. Am J Epidemiol. 1999;149:916–924

 The authors disclose the following: Supported in part by National Center for Research Resources grant 1K12 RR023248-04 (to M.D.K.) and National Institute for Diabetes and Digestive and Kidney Diseases grant 5P30 DK034987 (to M.D.K.).

PII: S0016-5085(08)01675-2

doi: 10.1053/j.gastro.2008.09.012

Gastroenterology
Volume 135, Issue 6 , Pages 1907-1913 , December 2008