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Gastroenterology
Volume 135, Issue 6
, Pages 1961-1971.e2
, December 2008
Clinical Correlates of Histopathology in Pediatric Nonalcoholic Steatohepatitis
References
- Prevalence of fatty liver in children and adolescents. Pediatrics. 2006;118:1388–1393
- . Pathology of nonalcoholic steatohepatitis. Hepatol Res. 2005;33:68–71
- Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology. 2002;123:134–140
- NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology. 2002;36:1349–1354
- Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. 1999;116:1413–1419
- . Children and teens told by doctors that they were overweight—United States, 1999–2002. MMWR Morb Mortal Wkly Rep. 2005;54:848–849
- Underdiagnosis of pediatric obesity and underscreening for fatty liver disease and metabolic syndrome by pediatricians and pediatric subspecialists. J Pediatr. 2005;147:839–842
- Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol. 2006;4:226–232
- Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology. 2005;42:641–649
- Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr. 2003;143:500–505
- . Nonalcoholic steatohepatitis clinical research network. Hepatology. 2003;37:244
- . Pediatric initiatives within the Nonalcoholic Steatohepatitis-Clinical Research Network (NASH CNR). J Pediatr Gastroenterol Nutr. 2003;37:220–221
- 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11. 2002;246:1–190
- Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
- Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402–2410
- Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321
- Comparison of adult and pediatric NAFLD—confirmation of a second pattern of progressive fatty liver disease in children. Hepatology. 2006;44:259A–260A
- . Categorical data analysis. New York, NY: John Wiley and Sons, Inc; 1990;
- . Regression models for ordinal data. J R Statist Soc B. 1980;42:109–142
- . Stata statistical software: release 10. College Station, TX: StataCorp LP; 2007;
- . Statistical analysis with missing data. 2nd edition. New York, NY: John Wiley and Sons, Inc; 2002;
- . Signal detection theory and psychophysics. New York, NY: John Wiley and Sons, Inc; 1966;
- . SAS, version 9.1. Cary, NC: SAS Institute Inc; 2007;
- . Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology. 2007;133:1814–1820
- Detection of antinuclear antibodies: comparative evaluation of enzyme immunoassay and indirect immunofluorescence methods. Arch Pathol Lab Med. 1998;122:993–999
- Prevalence of non-organ-specific autoantibodies and chronic liver disease in the general population: a nested case-control study of the Dionysos cohort. Gut. 1999;45:435–441
- Genetic predispositions for immunological features in chronic liver diseases other than autoimmune hepatitis. J Hepatol. 1996;24:52–59
- . The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease. Am J Gastroenterol. 2004;99:1316–1320
- Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates. Dig Dis Sci. 2003;48:2173–2181
- Diagnosing autoimmune hepatitis in nonalcoholic fatty liver disease: is the International Autoimmune Hepatitis Group scoring system useful?. J Gastroenterol. 2005;40:1130–1138
- Frequency of autoantibodies in normal children. Am J Dis Child. 1989;143:493–496
- Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr. 2006;43:413–427
- Effects of maturational stage on insulin sensitivity during puberty. J Clin Endocrinol Metab. 1993;77:725–730
- Pubertal alterations in growth and body composition (VI. Pubertal insulin resistance: relation to adiposity, body fat distribution and hormone release). Int J Obes Relat Metab Disord. 2002;26:701–709
- Prevalence of fatty liver in Japanese children and relationship to obesity (An epidemiological ultrasonographic survey). Dig Dis Sci. 1995;40:2002–2009
- Liver steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test. Int J Obes Relat Metab Disord. 2000;24:772–776
- Non-alcoholic steatohepatitis in children and adolescents. Med J Aust. 2000;173:476–479
- . Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl 4):S164–S192
- Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C. Hepatology. 2005;41:1376–1382
- APRI: an easy and validated predictor of hepatic fibrosis in chronic hepatitis C. J Clin Gastroenterol. 2006;40:535–542
- Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology. 2004;39:179–187
- Abnormal glucose tolerance is a predictor of steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease. Scand J Gastroenterol. 2005;40:1469–1477
- Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol. 2004;41:943–949
- Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology. 2007;133:80–90
- Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol. 2003;163:1301–1311
- . Progenitor cell involvement in cirrhotic human liver diseases: from controversy to consensus. J Hepatol. 2003;39:431–434
- Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology. 2004;39:1739–1745
- . Do you see what I see? (The role of quality histopathology in scientific study). Hepatology. 2008;47:771–774
- Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128:1898–1906
- Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease. Hepatology. 2006;44:874–880
The authors disclose the following: The Nonalcoholic Steatohepatitis Clinical Research Network is supported by the National Institutes of Diabetes and Digestive and Kidney Diseases (grants U01DK061718, U01DK061728, U01DK061731, U01DK061732, U01DK061734, U01DK061737, U01DK061738, U01DK061730, and U01DK061713), and the National Institutes of Child Health and Human Development. Several clinical centers receive support from General Clinical Research Centers or Clinical and Translational Science Awards in conduct of Nonalcoholic Steatohepatitis Clinical Research Network studies (grants UL1RR024989, M01RR000750, M01RR00188, RR02413101, M01RR000827, UL1RR02501401, M01RR000065, and M01RR020359). This study was supported in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute.
PII: S0016-5085(08)01549-7
doi: 10.1053/j.gastro.2008.08.050
© 2008 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 135, Issue 6
, Pages 1961-1971.e2
, December 2008

