Gastroenterology
Volume 135, Issue 5 , Pages 1575-1581 , November 2008

Re-weighting the Model for End-Stage Liver Disease Score Components

These findings were presented as an oral presentation at American Transplant Congress, 2007, held in San Francisco, California.

  • Pratima Sharma

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Douglas E. Schaubel

      Affiliations

    • Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
    • Scientific Registry of Transplant Recipients, Ann Arbor, Michigan
    • ,
  • Camelia S. Sima

      Affiliations

    • Scientific Registry of Transplant Recipients, Ann Arbor, Michigan
    • Arbor Research Collaborative for Health, Ann Arbor, Michigan
    • ,
  • Robert M. Merion

      Affiliations

    • Scientific Registry of Transplant Recipients, Ann Arbor, Michigan
    • Department of Surgery, University of Michigan, Ann Arbor, Michigan
    • ,
  • Anna S.F. Lok

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationAddress requests for reprints to: Anna S. F. Lok, MD, Professor of Medicine, Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, SPC 5362, Ann Arbor, Michigan 48109. fax: (734) 936-7392

Received 22 October 2007 ,Accepted 7 August 2008.

References 

  1. Wiesner R, Edwards E, Freeman R, et al. Model for End-Stage Liver Disease (MELD) and allocation of donor livers. Gastroenterology. 2003;124:91–96
  2. Malinchoc M, Kamath PS, Gordon FD, et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology. 2000;31:864–871
  3. Huo TI, Wu JC, Lin HC, et al. Evaluation of the increase in Model for End-Stage Liver Disease (DeltaMELD) score over time as a prognostic predictor in patients with advanced cirrhosis: risk factor analysis and comparison with initial MELD and Child-Turcotte-Pugh score. J Hepatol. 2005;42:826–832
  4. Heuman DM, Mihas A. Utility of the MELD score for assessing 3-month survival in patients with liver cirrhosis: one more positive answer. Gastroenterology. 2003;125:992–995
  5. Wiesner RH, Edwards E, Kamath P. Mayo End-Stage Liver Disease (MELD) model predicts liver transplant waiting list mortality: implications for liver allocation policy. Transplantation. 2001;71:461
  6. Kim W, Kremers W, Malinchoc M, et al. Determinant of death on liver transplant waiting list: waiting time, blood group or MELD?. Hepatology. 2001;34:204A
  7. Merion RM, Rush SH, Dykstra DM, et al. Predicted lifetimes for adult and pediatric split liver versus adult whole liver transplant recipients. Am J Transplant. 2004;4:1792–1797
  8. Gonwa TA, McBride MA, Anderson K, et al. Continued influence of preoperative renal function on outcome of orthotopic liver transplant (OLTX) in the US: where will MELD lead us?. Am J Transplant. 2006;6:2651–2659
  9. Pomfret EA, Fryer JP, Sima CS, et al. Liver and intestine transplantation in the United States, 1996–2005. Am J Transplant. 2007;7(Suppl 1):1376–1389
  10. Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data. New York: Wiley; 2002;
  11. Allison PD. Survival analysis using SAS: a practical guide. Cary, NC: SAS Institute; 1995;
  12. Harrell FE, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15:361–387
  13. Schemper M, Stare J. Explained variation in survival analysis. Stat Med. 1996;15:1999–2012
  14. Organ procurement and transplant network-HRSA (Final rule with comment period). Anonymous Federal Register. 1998;63:16296–16338
  15. Brown RS, Rush SH, Rosen HR, et al. Liver and intestine transplantation. Am J Transplant. 2004;4(Suppl 9):81–92
  16. Nair S, Verma S, Thuluvath PJ. Pretransplant renal function predicts survival in patients undergoing orthotopic liver transplantation. Hepatology. 2002;35:1179–1185
  17. Narayanan Menon KV, Nyberg SL, Harmsen WS, et al. MELD and other factors associated with survival after liver transplantation. Am J Transplant. 2004;4:819–825

 Supported by the Scientific Registry of Transplant Recipients funded by contract number 231-00-0116 from the Health Resources and Services Administration, US Department of Health and Human Services. The statistical methodology development and analysis for this investigation was supported by the National Institutes of Health grant R01 DK-70869 (to D.E.S.). The views expressed in this paper are those of the authors and are not necessarily those of the US government.

 The authors disclose no conflicts.

PII: S0016-5085(08)01509-6

doi: 10.1053/j.gastro.2008.08.004

Gastroenterology
Volume 135, Issue 5 , Pages 1575-1581 , November 2008

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