Pancreatic Cancer Development and Progression: Remodeling the Model

Pancreatic ductal adenocarcinoma (PDAC) remains a formidable problem. The challenges are such that, to win the war against this disease, it will be necessary to make advances in multiple areas. Specifically, we need to better understand the genetic and environmental causes of the disease and the mechanisms involved in its development and progression. In addition, novel strategies for early diagnosis and significant improvements in treatment are needed. Advances in genomics and proteomics, recently established mouse models of the disease, the implementation of noninvasive imaging techniques, the development of targeted therapies, and the inclusion of more patients into clinical studies will contribute. Given the magnitude of the challenge, a dose of good luck may also be required.