Gastroenterology
Volume 135, Issue 4 , Pages 1142-1154, October 2008

A Controlled Pharmacogenetic Trial of Sibutramine on Weight Loss and Body Composition in Obese or Overweight Adults

  • April B.M. Grudell

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • ,
  • Seth Sweetser

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • ,
  • Michael Camilleri

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationAddress requests for reprints to: Michael Camilleri, MD, Mayo Clinic, Charlton 8-110, 200 First Street, SW, Rochester, Minnesota 55905
    • ,
  • Deborah J. Eckert

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • ,
  • Maria I. Vazquez-Roque

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • ,
  • Paula J. Carlson

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • ,
  • Duane D. Burton

      Affiliations

    • Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota
    • ,
  • Autumn E. Braddock

      Affiliations

    • Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Matthew M. Clark

      Affiliations

    • Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Karen M. Graszer

      Affiliations

    • Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Sarah A. Kalsy

      Affiliations

    • Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Alan R. Zinsmeister

      Affiliations

    • Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic, Rochester, Minnesota

Received 10 April 2008; accepted 2 July 2008. published online 18 July 2008.

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 Supported in part by National Institutes of Health grants RO1 DK 67071 and K24 DK 02638 (to M.C.); by NIH grant RR024150, which supports the Mayo Clinical Research Unit; and, for DEXA measurements, by Public Health Service grant DK50456, which funds the Minnesota Obesity Center.

 Registration number of clinical trial at Clinical Trials.gov: NCT 00433641.

 Conflicts of interest: The authors have no conflicts of interest to disclose.

PII: S0016-5085(08)01317-6

doi:10.1053/j.gastro.2008.07.009

Gastroenterology
Volume 135, Issue 4 , Pages 1142-1154, October 2008

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