Gastroenterology
Volume 135, Issue 2 , Pages 351-354 , August 2008

Guardians of the Gut: Newly Appreciated Role of Epithelial Toll-Like Receptors in Protecting the Intestine

  • Matam Vijay-Kumar
    • ,
  • Andrew T. Gewirtz

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Andrew T. Gewirtz, PhD, Associate Professor of Pathology, 105–H, 615 Michael Street, Emory University, Atlanta GA 30322

References 

  1. Gewirtz AT, Navas TA, Lyons S, et al. Cutting edge: bacterial flagellin activates basolaterally expressed tlr5 to induce epithelial proinflammatory gene expression. J Immunol. 2001;167:1882–1885
  2. Rhee SH, Im E, Pothoulakis C. Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology. 2008;135:518–528
  3. Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology. 2004;127:224–238
  4. Abreu MT, Arnold ET, Thomas LS, et al. TLR4 and MD-2 expression are regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem. 2002;28:28
  5. Shang L, Dukata M, Thirunarayana N, et al. Toll-like receptor signalling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology. 2008;135:529–538
  6. Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol. 1998;161:5733–5744
  7. Vijay-Kumar M, Aitken JD, Kumar A, et al. Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun. 2008;76:1276–1281
  8. Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. 2007;317:124–127
  9. Burdelya LG, Krivokrysenko VI, Tallant TC, et al. An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models. Science. 2008;320:226–230
  10. Vijay-Kumar M, Sanders CJ, Sloane V, et al. Flagellin treatment provides protection against radiation, chemicals, bacteria, and viruses. J Immunol. 2008;180:8280–8285
  11. Sfondrini L, Rossini A, Besusso D, et al. Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer. J Immunol. 2006;176:6624–6630

PII: S0016-5085(08)01185-2

doi: 10.1053/j.gastro.2008.06.064

Gastroenterology
Volume 135, Issue 2 , Pages 351-354 , August 2008

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