Gastroenterology
Volume 135, Issue 4 , Pages 1069-1078 , October 2008

Spectroscopic Microvascular Blood Detection From the Endoscopically Normal Colonic Mucosa: Biomarker for Neoplasia Risk

Presented in part in abstract form at the 108th Digestive Disease Week Meetings, May 19–24, 2007, Washington, DC.

  • Hemant K. Roy

      Affiliations

    • Department of Internal Medicine, Evanston-Northwestern Healthcare, Evanston, Illinois
    • Corresponding Author InformationAddress reprint requests to: Hemant K. Roy, MD, Associate Professor, Feinberg School of Medicine at Northwestern University, Section of Gastroenterology, Evanston-Northwestern Healthcare, G208, Evanston Hospital, 2650 Ridge Avenue, Evanston, Illinois 60201. fax: (847) 733-5041
    • ,
  • Andrew Gomes

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois
    • ,
  • Vladimir Turzhitsky

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois
    • ,
  • Michael J. Goldberg

      Affiliations

    • Department of Internal Medicine, Evanston-Northwestern Healthcare, Evanston, Illinois
    • ,
  • Jeremy Rogers

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois
    • ,
  • Sarah Ruderman

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois
    • ,
  • Kim L. Young

      Affiliations

    • Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • ,
  • Alex Kromine

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois
    • ,
  • Randall E. Brand

      Affiliations

    • Department of Biomedical Engineering, Purdue University, West Lafayette, Indiana
    • ,
  • Mohammed Jameel

      Affiliations

    • Department of Internal Medicine, Evanston-Northwestern Healthcare, Evanston, Illinois
    • ,
  • Parmede Vakil

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois
    • ,
  • Nahla Hasabou

      Affiliations

    • Department of Internal Medicine, Evanston-Northwestern Healthcare, Evanston, Illinois
    • ,
  • Vadim Backman

      Affiliations

    • Biomedical Engineering Department, Northwestern University, Evanston, Illinois

Received 12 April 2008 ,Accepted 19 June 2008.

References 

  1. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy (The National Polyp Study Workgroup). N Engl J Med. 1993;329:1977–1981
  2. Levin B, Lieberman DA, McFarland B, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology. 2008;134:1570
  3. Lewis JD, Ng K, Hung KE, et al. Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy. Arch Intern Med. 2003;163:413–420
  4. Takayama T, Katsuki S, Takahashi Y, et al. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med. 1998;339:1277–1284
  5. Anti M, Marra G, Armelao F, et al. Rectal epithelial cell proliferation patterns as predictors of adenomatous colorectal polyp recurrence. Gut. 1993;34:525–530
  6. Bernstein C, Bernstein H, Garewal H, et al. A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies. Cancer Res. 1999;59:2353–2357
  7. McGarrity TJ, Peiffer LP. Protein kinase C activity as a potential marker for colorectal neoplasia. Dig Dis Sci. 1994;39:458–463
  8. Chen L, Hao C, Chiu Y, et al. Alteration of gene expression in normal-appearing colon mucosa of APCmin mice and human cancer patients. Cancer Res. 2004;64:3694–3700
  9. Polley AC, Mulholland F, Pin C, et al. Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Res. 2006;66:6553–6562
  10. Roy HK, Liu Y, Wali RK, et al. Four-dimensional elastic light-scattering fingerprints as preneoplastic markers in the rat model of colon carcinogenesis. Gastroenterology. 2004;126:1071–1081
  11. Wali RK, Roy HK, Kim YL, et al. Increased microvascular blood content is an early event in colon carcinogenesis. Gut. 2005;54:654–660
  12. Roy HK, Wali RK, Kim Y, et al. Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett. 2007;581:3857–3862
  13. Liu Y, Kim YL, Li X, et al. Investigation of depth selectivity of polarization gating for tissue characterization. Optics Express. 2005;13:601–611
  14. Siegel MP, Kim YL, Roy HK, et al. Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy. Appl Opt. 2006;45:335–342
  15. Finlay JC, Foster TH. Effect of pigment packaging on diffuse reflectance spectroscopy of samples containing red blood cells. Opt Lett. 2004;29:965–967
  16. Aotake T, Lu CD, Chiba Y, et al. Changes of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis. Clin Cancer Res. 1999;5:135–142
  17. Shpitz B, Gochberg S, Neufeld D, et al. Angiogenic switch in earliest stages of human colonic tumorigenesis. Anticancer Res. 2003;23:5153–5157
  18. Sun XF, Zhang H, Wu XC, et al. Microvascular corrosion casting of normal tissue, transitional mucosa and adenocarcinoma in the human colon. Acta Oncol. 1992;31:37–40
  19. Payne CM, Holubec H, Bernstein C, et al. Crypt-restricted loss and decreased protein expression of cytochrome C oxidase subunit I as potential hypothesis-driven biomarkers of colon cancer risk. Cancer Epidemiol Biomarkers Prev. 2005;14:2066–2075
  20. Jothy S, Slesak B, Harlozinska A, et al. Field effect of human colon carcinoma on normal mucosa: relevance of carcinoembryonic antigen expression. Tumour Biol. 1996;17:58–64
  21. Ambs S, Merriam WG, Bennett WP, et al. Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res. 1998;58:334–341
  22. Sweet K, Willis J, Zhou XP, et al. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. JAMA. 2005;294:2465–2473
  23. Noonan DM, Benelli R, Albini A. Angiogenesis and cancer prevention: a vision. Recent Results Cancer Res. 2007;174:219–224
  24. Ahn B, Ohshima H. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res. 2001;61:8357–8360
  25. Sinicrope FA. Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. Mol Carcinog. 2006;45:447–454
  26. Bertagnolli MM, Eagle CJ, Zauber AG, et al. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med. 2006;355:873–884
  27. Goodlad RA, Ryan AJ, Wedge SR, et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis. 2006;27:2133–2139
  28. Sawhney MS, Farrar WD, Gudiseva S, et al. Microsatellite instability in interval colon cancers. Gastroenterology. 2006;131:1700–1705
  29. van Rijn JC, Reitsma JB, Stoker J, et al. Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol. 2006;101:343–350
  30. Pickhardt PJ, Nugent PA, Mysliwiec PA, et al. Location of adenomas missed by optical colonoscopy. Ann Intern Med. 2004;141:352–359
  31. Barclay RL, Vicari JJ, Doughty AS, et al. Colonoscopic withdrawal times and adenoma detection during screening colonoscopy. N Engl J Med. 2006;355:2533–2541
  32. Gupta S, Durkalski V, Cotton P, et al. Variation of agreement in polyp size measurement between computed tomographic colonography and pathology assessment: clinical implications. Clin Gastroenterol Hepatol. 2008;6:220–227
  33. Jass JR. Hyperplastic polyps and colorectal cancer: is there a link?. Clin Gastroenterol Hepatol. 2004;2:1–8

 Supported in part by National Institutes of Health grants U01 CA111257, R42CA130508, R01 CA112315, R01 EB003682, R01 CA118794, R01 CA109861, and R01 CA128641, and National Science Foundation grant CBET-0733868. Drs Roy, Goldberg, and Backman are cofounders and shareholders of American BioOptics LLC.

PII: S0016-5085(08)01100-1

doi: 10.1053/j.gastro.2008.06.046

Gastroenterology
Volume 135, Issue 4 , Pages 1069-1078 , October 2008

Article Tools

* Image Usage & Resolution