Gastroenterology
Volume 135, Issue 3 , Pages 926-936.e2 , September 2008

Proinflammatory Role of Leukocyte-Derived Egr-1 in the Development of Murine Postoperative Ileus

Received 27 February 2007 ,Accepted 29 May 2008.

References 

  1. Thiel G, Cibelli G. Regulation of life and death by the zinc finger transcription factor Egr-1. J Cell Physiol. 2002;193:287–292
  2. Yan SF, Lu J, Xu L, et al. Pulmonary expression of early growth response-1: biphasic time course and effect of oxygen concentration. J Appl Physiol. 2000;88:2303–2309
  3. Khachigian LM. Early growth response-1 in cardiovascular pathobiology. Circ Res. 2006;98:186–191
  4. Pawlinski R, Pedersen B, Kehrle B, et al. Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood. 2003;101:3940–3947
  5. Mishra S, Fujita T, Lama VN, et al. Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes. Proc Natl Acad Sci U S A. 2006;103:5191–5196
  6. Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus. Neurogastroenterol Motil. 2004;16(Suppl):54–60
  7. Nakao A, Schmidt J, Harada T, et al. A single intraperitoneal dose of carbon monoxide-saturated Ringer's lactate solution ameliorates postoperative ileus in mice. J Pharmacol Exp Ther. 2006;319:1265–1275
  8. Wehner S, Schwarz NT, Hundsdoerfer R, et al. Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery. 2005;137:436–446
  9. Galeazzi F, Haapala EM, Van Rooijen N, et al. Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. Am J Physiol Gastrointest Liver Physiol. 2000;278:G259–G265
  10. Turler A, Kalff JC, Moore BA, et al. Leukocyte-derived inducible nitric oxide synthase mediates murine postoperative ileus. Ann Surg. 2006;244:220–229
  11. Schwarz NT, Kalff JC, Türler A, et al. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology. 2001;121:1354–1371
  12. Moore BA, Otterbein LE, Türler A, et al. Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Gastroenterology. 2003;124:377–391
  13. Moore BA, Overhaus M, Whitcomb J, et al. Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med. 2005;33:1317–1326
  14. Kilduff TS, Vugrinic C, Lee SL, et al. Characterization of the circadian system of NGFI-A and NGFI-A/NGFI-B deficient mice. J Biol Rhythms. 1998;13:347–357
  15. Lee SL, Sadovsky Y, Swirnoff AH, et al. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996;273:1219–1221
  16. Lee SL, Wang Y, Milbrandt J. Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1). Mol Cell Biol. 1996;16:4566–4572
  17. Lee SL, Tourtellotte LC, Wesselschmidt RL, et al. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J Biol Chem. 1995;270:9971–9977
  18. Eskandari MK, Kalff JC, Billiar TR, et al. LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. Am J Physiol Gastrointest Liver Physiol. 1999;277:G478–G486
  19. Moore BA, Turler A, Pezzone MA, et al. Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon. Am J Physiol Gastrointest Liver Physiol. 2004;286:G214–G224
  20. Kalff JC, Schraut WH, Billiar TR, et al. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology. 2000;118:316–327
  21. Yan SF, Fujita T, Lu J, et al. Egr-1, a master switch coordinating up-regulation of divergent gene families underlying ischemic stress. (erratum appears in Nat Med 2001;April 7:509) Nat Med. 2000;6:1355–1361
  22. Sukhatme VP. Early transcriptional events in cell growth: the Egr family. J Am Soc Nephrol. 1990;1:859–866
  23. The FO, de Jonge WJ, Bennink RJ, et al. The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice. Br J Pharmacol. 2005;146:252–258
  24. Chiu JJ, Wung BS, Hsieh HJ, et al. Nitric oxide regulates shear stress-induced early growth response-1 (Expression via the extracellular signal-regulated kinase pathway in endothelial cells). Circ Res. 1999;85:238–246
  25. Keil A, Blom IE, Goldschmeding R, et al. Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells. Kidney Int. 2002;62:401–411
  26. Subbaramaiah K, Yoshimatsu K, Scherl E, et al. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease: evidence for involvement of the transcription factor Egr-1. J Biol Chem. 2004;279:12647–12658
  27. Silverman ES, Du J, De Sanctis GT, et al. Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants. Am J Respir Cell Mol Biol. 1998;19:316–323
  28. Ji B, Chen XQ, Misek DE, et al. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Physiol Genomics. 2003;14:59–72
  29. Prince JM, Ming MJ, Levy RM, et al. Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock. 2007;27:157–164
  30. Watanabe S, Kubota H, Sakamoto KM, et al. Characterization of cis-acting sequences and trans-acting signals regulating early growth response 1 and c-fos promoters through the granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. Blood. 1997;89:1197–1206
  31. Li C, Mitchell DH, Coleman DL. Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor. Yale J Biol Med. 1994;67:269–276
  32. Krishnaraju K, Nguyen HQ, Liebermann DA, et al. The zinc finger transcription factor Egr-1 potentiates macrophage differentiation of hematopoietic cells. Mol Cell Biol. 1995;15:5499–5507
  33. Lee SL, Wang Y, Milbrandt J. Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1). Mol Cell Biol. 1996;16:4566–4572

 Supported by National Institutes of Health grants R01-GM58241, R01-DK068610, and P50-GM53789.

 Conflicts of interest: No conflicts of interest exist.

PII: S0016-5085(08)00954-2

doi: 10.1053/j.gastro.2008.05.079

Gastroenterology
Volume 135, Issue 3 , Pages 926-936.e2 , September 2008