Gastroenterology
Volume 135, Issue 3 , Pages 787-795 , September 2008

Safety and Immunogenicity of an Intramuscular Helicobacter pylori Vaccine in Noninfected Volunteers: A Phase I Study

  • Peter Malfertheiner

      Affiliations

    • Otto-von-Guericke Universitaet, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    • ,
  • Viola Schultze

      Affiliations

    • Novartis Vaccines, Marburg, Germany
    • ,
  • Bernd Rosenkranz

      Affiliations

    • Clinical Research, Universitaetsklinikum Charité, Berlin, Germany
    • ,
  • Stefan H.E. Kaufmann

      Affiliations

    • Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    • ,
  • Timo Ulrichs

      Affiliations

    • Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    • ,
  • Deborah Novicki

      Affiliations

    • Novartis Vaccines, Emeryville, California
    • ,
  • Francesco Norelli

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Mario Contorni

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Samuele Peppoloni

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Duccio Berti

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Daniela Tornese

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Jitendra Ganju

      Affiliations

    • Novartis Vaccines, Emeryville, California
    • ,
  • Emanuela Palla

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Rino Rappuoli

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • ,
  • Bruce F. Scharschmidt

      Affiliations

    • Novartis Vaccines, Emeryville, California
    • ,
  • Giuseppe Del Giudice

      Affiliations

    • Novartis Vaccines, Siena, Italy
    • Corresponding Author InformationAddress requests for reprints to: Giuseppe Del Giudice, MD, Novartis Vaccines, Research Center, Via Fiorentina 1, 53100 Siena, Italy. fax: +39-0577-243564

Received 6 September 2007 ,Accepted 21 May 2008.

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 Sponsored by Chiron Corporation (now Novartis Vaccines). P. Malfertheiner, S.H.E. Kaufmann, and T. Ulrichs have no financial interest in the product and have no other conflicting interests. B. Rosenkranz was employee of the phase I unit and CRO. At the time of the study V. Schultze, D. Novicki, F. Norelli, M. Contorni, D. Berti, S. Peppoloni, D. Tornese, J. Ganju, E. Palla, R. Rappuoli, B.F. Scharschmidt, and G. Del Giudice were employees of Chiron Corporation (now Novartis Vaccines).

PII: S0016-5085(08)00902-5

doi: 10.1053/j.gastro.2008.05.054

Gastroenterology
Volume 135, Issue 3 , Pages 787-795 , September 2008

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