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Gastroenterology
Volume 135, Issue 2
, Pages 438-450
, August 2008
Critical Review of Clinical Trials of Bone Marrow Stem Cells in Liver Disease
References
- Bone marrow as a potential source of hepatic oval cells. Science. 1999;284:1168–1170
- . Stem cells: units of development, units of regeneration and units in evolution. Cell. 2000;100:157–168
- . The evolving concept of a stem cell: entity or function?. Cell. 2001;105:829–841
- . Adult stem cells for tissue repair—a new therapeutic concept?. N Engl J Med. 2003;349:570–582
- . Adult bone marrow cells regenerate myocardium in ischemic heart disease. Ann N Y Acad Sci. 2003;996:152–157
- Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol. 1997;151:1273–1280
- Replacement of diseased mouse liver by hepatic cell transplantation. Science. 1994;263:1149–1152
- Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J. 2002;16:935–942
- . The telomere hypothesis for progressive liver cirrhosis. J Hepatol. 2003;38:378–379
- . Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury. Am J Pathol. 2000;157:561–569
- . Hepatic oval cells: helping redefine a paradigm in stem cell biology. Curr Top Dev Biol. 2004;61:1–128
- . Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatology. 1998;27:1030–1038
- Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am J Pathol. 2000;156:607–619
- Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology. 2007;132:1077–1087
- Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells. Haematologica. 2003;88:368–378
- The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A. 2003;100:11881–11888
- Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells. 2004;22:1049–1061
- Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology. 2003;124:1891–1900
- Liver from bone marrow in humans. Hepatology. 2000;32:11–16
- Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 2002;346:738–746
- Hepatocytes from non-hepatic adult stem cells. Nature. 2000;406:257
- Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloblation. Hepatology. 2000;31:235–240
- Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;105:369–377
- Isolation, characterisation and transplantation of bone marrow-derived hepatocyte stem cells. Biochem Biophys Res Commun. 2001;288:156–164
- Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo. Hepatology. 2002;35:799–804
- Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000;6:1229–1234
- . Transplanted bone marrow regenerates liver by cell fusion. Nature. 2003;422:901–904
- Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature. 2003;422:897–901
- Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 1998;279:1528–1530
- Bone marrow cells regenerate infracted myocardium. Nature. 2001;410:701–705
- Hematopoietic mobilisation in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion. Hepatology. 2006;43:108–116
- . Direct evidence of macrophage differentiation from bone marrow cells in the liver: a possible origin of Kupffer cells. J Biochem (Tokyo). 1995;118:1175–1183
- The bone marrow functionally contributes to liver fibrosis. Gastroenterology. 2006;130:1807–1821
- Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol. 2006;45:429–438
- Transplantation of bone marrow cells reduces CCL4-induced liver fibrosis in mice. Hepatology. 2004;40:1304–1311
- Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation. 2004;78:83–88
- Bone marrow derived mesenchymal stem cells protect against experimental liver fibrosis in rats. World J Gastroenterol. 2005;11:3431–3440
- Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol. 2006;44:742–748
- Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease. J Hepatol. 2006;45:13–19
- Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells. 2006;24:2292–2298
- Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis. World J Gastroenterol. 2007;28:3359–3363
- Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Arch Iran Med. 2007;10:459–466
- Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World J Gastroenterol. 2007;13:1067–1073
- A pilot randomised controlled study used to evaluate efficacy of autologous bone marrow mononuclear cells transplantation in patients with advanced chronic liver disease. Hepatology. 2007;46(Suppl 1):271A;(abstr)
- Characterisation and clinical application of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. Stem Cells. 2006;24:1822–1830
- Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34+ cells in patients with chronic liver disease. Cell Prolif. 2008;41:115–125
- Lasting amelioration in the clinical course of decompensated alcoholic cirrhosis with boost infusions of mobilized peripheral blood stem cells. Exp Hematol. 2006;34:1583–1587
- Portal application of autologous CD133+ bone marrow cells to the liver: a novel concept to support hepatic regeneration. Stem Cells. 2005;23:463–470
- Portal vein embolisation and autologous CD133+ bone marrow stem cells for liver regeneration: initial experience. Radiology. 2007;243:171–179
- Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol. 2004;6:532–539
- The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes. J Biol Chem. 2003;278:31691–31700
- . Type I collagen structure regulates cell morphology and EGF signalling in primary rat hepatocytes through cAMP-dependant protein kinase A. Mol Biol Cell. 2006;17:345–356
- Role of replicative senescence in the progression of fibrosis in hepatitis C virus (HCV) recurrence after liver transplantation. Transplantation. 2004;77:1755–1760
- Endothelial progenitor cell transplantation improves the survival following liver injury in mice. Gastroenterology. 2006;130:521–531
- Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model. Gastroenterology. 2007;133:91–107
- Angiogenic cell therapy for hepatic fibrosis. Med Mol Morphol. 2006;39:16–21
- The impact of bone marrow stem cells on liver fibrosis in critically determined by their route of cell trafficking. Hepatology. 2007;46:710A
- Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology. 2007;46:219–228
- CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells. 1998;16:387–396
- A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1Oct-4(+) stem cells identified in adult bone marrow. Leukemia. 2006;20:857–869
- Morphological and molecular characterisation of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report. Leukemia. 2007;21:297–303
- Minimal criteria for defining multipotent mesenchymal stromal cells (The International Society for Cellular Therapy position statement). Cytotherapy. 2006;8:315–317
- . Mesenchymal stem cell preparations-comparing apples and oranges. Stem Cell Rev. 2007;3:239–248
- Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease. Differentiation. 2008;76:495–505
- Differentiation of mesenchymal cells derived from human amniotic membranes into hepatocyte-like cells in vitro. Hum Cell. 2007;20:77–84
- Adult-derived human liver mesenchymal-like cells as a potential progenitor reservoir of hepatocytes?. Cell Transplant. 2007;16:717–728
- Human mesenchymal stem cells xenografted directly to rat are differentiated into human hepatocytes without fusion. Blood. 2005;106:756–763
- Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats. Gastroenterology. 2007;133:619–631
- G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs. Exp Haematol. 2005;33:108–119
- . Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007;110:3499–3506
- Mesenchymal stem cell-mediated immunosuppression occurs via concerted actions of chemokines and nitric oxide. Cell Stem Cell. 2008;2:141–150
- Treatment of acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet. 2004;363:1439–1441
- Prochymal Crohn's Disease Phase II Clinical Trial Data. http://www.osiris.comAccessed 29 June 2008
- . Advances in cell-based therapy for structural heart disease. Prog Cardiovasc Dis. 2007;49:387–395
- . Stem cells and their potential in cell-based cardiac therapies. Prog Cardiovasc Dis. 2007;49:396–413
- Hematopoietic stem cells mobilized by granulocyte colony-stimulating factor partly contribute to liver graft regeneration after partial orthotopic liver transplantation. Liver Transpl. 2006;12:1129–1137
- Partial hepatectomy induces mobilization of a unique population of haematopoietic progenitor cells in human healthy liver donors. J Hepatol. 2005;43:845–853
- Implication of inflammation-related cytokines in the natural history of liver cirrhosis. Liver Int. 2004;24:437–445
- Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis. Am J Gastroenterol. 1999;94:169–177
- Cell tracing techniques in stem cell transplantation. Stem Cell Rev. 2007;3:265–269
- Haemopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature. 2007;449:238–242
- Differential homing and engraftment properties of hematopoietic progenitor cells from murine bone marrow, mobilized peripheral blood, and fetal liver. Blood. 2001;98:2108–2115
- Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats. Transplantation Proc. 2006;38:3082–3085
- Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage. 2002;17:803–811
- Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infracted myocardium. Circulation. 2007;116:I38–I145
- In vivo visualisation of 111In labelled CD133+ peripheral blood stem cells after intracoronary administration in patients with chronic ischaemic heart disease. Q J Nucl Med Mol Imaging. 2007;51:61–66
- The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs. 2001;169:12–20
- Hematopoietic stem cell trafficking in liver injury. FASEB J. 2005;19:1225–1231
- Hepatic stellate cells do not derive from the neural crest. J Hepatol. 2006;44:1098–1104
- . Origin of hepatocellular carcinoma: role of stem cells. J Gastroenterol Hepatol. 2006;21:1093–1098
- Generation and characterisation of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis. 2002;23:435–445
- Ha-rasVal12 but not p53ser247 leads to a significant neoplastic transformation rate of the putative rat liver stem cells (oval cell). Carcinogenesis. 1996;17:2635–2640
- Spontaneous human adult stem cell transformation. Cancer Res. 2005;65:3035–3039
- Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene. 2004;23:5095–5098
- Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients. World J Gastroenterol. 2004;15:2394–2396
- Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis. Am J Clin Pathol. 1999;112:351–357
- Use of proliferating cell nuclear antigen as a marker of liver regeneration after partial hepatectomy in rats. J Lab Clin Med. 1998;131:251–256
- VEGF is important for early liver regeneration after partial hepatectomy. J Surg Res. 2007;138:291–299
- Interleukin 6 and liver regeneration. Gut. 2000;47:309–312
- Il-10 attenuates hepatic I/R injury and promotes hepatocyte proliferation. J Surg Res. 2007;141:176–182
- Expression of suppressors of cytokine signalling during liver regeneration. J Clin Invest. 2001;107:1285–1292
- . Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 2003;38:1449–1457
- Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002;97:2614–2618
- Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004;127:1704–1713
- Noninvasive markers of fibrosis in non-alcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology. 2008;47:455–460
PII: S0016-5085(08)00861-5
doi: 10.1053/j.gastro.2008.05.040
© 2008 AGA Institute. Published by Elsevier Inc. All rights reserved.
« Previous
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Gastroenterology
Volume 135, Issue 2
, Pages 438-450
, August 2008

