Gastroenterology
Volume 135, Issue 2 , Pages 489-498.e7, August 2008

Analysis of Mutations in DNA Isolated From Plasma and Stool of Colorectal Cancer Patients

  • Frank Diehl

      Affiliations

    • The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Baltimore, Maryland
    • ,
  • Kerstin Schmidt

      Affiliations

    • The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Baltimore, Maryland
    • ,
  • Kristine H. Durkee

      Affiliations

    • Exact Sciences Corp., Marlborough, Massachusetts
    • ,
  • Kent J. Moore

      Affiliations

    • Exact Sciences Corp., Marlborough, Massachusetts
    • ,
  • Steve N. Goodman

      Affiliations

    • Department of Biostatistics, Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • Anthony P. Shuber

      Affiliations

    • Predictive Biosciences, Inc, Lexington, Massachusetts
    • ,
  • Kenneth W. Kinzler

      Affiliations

    • The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Baltimore, Maryland
    • ,
  • Bert Vogelstein

      Affiliations

    • The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Baltimore, Maryland
    • Corresponding Author InformationAddress reprint requests to: Bert Vogelstein, MD, The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, CRB520, Baltimore, Maryland 21231. fax: (410) 955-0548.

Received 17 March 2008; accepted 8 May 2008. published online 20 May 2008.

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 This work was supported by the Virginia and D.K. Ludwig Fund for Cancer Research, The Miracle Foundation, The National Colorectal Cancer Research Alliance, and National Institutes of Health grants CA43460, CA57345, CA62924, and CA129825. Under agreements between the Johns Hopkins University and Exact Sciences, Inc, Genzyme Molecular Oncology, Inc, and Beckman Instruments, Inc, Kenneth W. Kinzler and Bert Vogelstein are entitled to a share of the royalties received by the University on sales of products related to certain genes described in this article. The University and these authors also own stock in Exact Sciences, Inc, and Genzyme, Inc, which is subject to certain restrictions under University policy. The terms of these arrangements are being managed by the University in accordance with its conflict of interest policies. K.H.D. and K.J.M. are employees and shareholders of Exact Sciences Corp.

PII: S0016-5085(08)00860-3

doi:10.1053/j.gastro.2008.05.039

Gastroenterology
Volume 135, Issue 2 , Pages 489-498.e7, August 2008

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