Gastroenterology
Volume 135, Issue 2 , Pages 642-659.e46, August 2008

Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage

  • Steven Dooley

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • Corresponding Author InformationAddress requests for reprints to: Steven Dooley, Dr rer nat, Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Theodor-Kutzer Ufer 1-3, 68135 Mannheim, Germany
    • ,
  • Jafar Hamzavi

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Loredana Ciuclan

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Patricio Godoy

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Iryna Ilkavets

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Sabrina Ehnert

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Elke Ueberham

      Affiliations

    • Institute of Biochemistry, University Leipzig, Leipzig, Germany
    • ,
  • Rolf Gebhardt

      Affiliations

    • Institute of Biochemistry, University Leipzig, Leipzig, Germany
    • ,
  • Stephan Kanzler

      Affiliations

    • Department of Medicine, Johannes-Gutenberg-Universitat, Mainz, Germany
    • ,
  • Andreas Geier

      Affiliations

    • Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    • ,
  • Katja Breitkopf

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Honglei Weng

      Affiliations

    • Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    • ,
  • Peter R. Mertens

      Affiliations

    • Nephrology and Clinical Immunology, University Hospital RWTH-Aachen, Aachen, Germany

Received 12 July 2007; accepted 21 April 2008. published online 16 May 2008.

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 The authors report no financial conflicts of interest.

 Supported by the Deutsche Forschungsgemeinschaft DO373/6-1 (S.D.), BMBF “Hepatosys” (S.D.), Sonderforschungsbereich 542, projects C1 (A.G.) and C4 and C12 (P.R.M.); START fibrosis project of the University Hospital Aachen (S.D. and J.H.); Stiftung Pathobiochemie und Molekulare Diagnostik der Deutschen Vereinten Gesellschaft für Klinische Chemie und Laboratoriumsmedizin; and the Dietmar Hopp Stiftung GmbH (S.D.). H.W. was the recipient of a DAAD fellowship (Bioscience special program).

PII: S0016-5085(08)00858-5

doi:10.1053/j.gastro.2008.04.038

Gastroenterology
Volume 135, Issue 2 , Pages 642-659.e46, August 2008

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