Gastroenterology
Volume 135, Issue 2 , Pages 610-620.e2 , August 2008

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

  • Wei–Qi He

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Ya–Jing Peng

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Wen–Cheng Zhang

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Ning Lv

      Affiliations

    • Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, Nanjing, China
    • ,
  • Jing Tang

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Chen Chen

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Cheng–Hai Zhang

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Song Gao

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • ,
  • Hua–Qun Chen

      Affiliations

    • Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, Nanjing, China
    • ,
  • Gang Zhi

      Affiliations

    • National Institute of Biological Science, Beijing, China
    • ,
  • Robert Feil

      Affiliations

    • Interfakultäres Institut für Biochemie (IFIB), Signaltransduktion–Transgene Modelle, Universität Tübingen, Tübingen, Germany
    • ,
  • Kristine E. Kamm

      Affiliations

    • Department of Physiology, UT Southwestern Medical Center, Dallas, Texas, USA
    • ,
  • James T. Stull

      Affiliations

    • Department of Physiology, UT Southwestern Medical Center, Dallas, Texas, USA
    • ,
  • Xiang Gao

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • Corresponding Author InformationAddress requests for reprints to: Min-Sheng Zhu, PhD, or Xiang Gao, PhD, Model Animal Research Center, Nanjing University, 12 Xue-Fu Road, Pukou District, Nanjing 210061, China. fax: (86) 25-58641500.
    • ,
  • Min–Sheng Zhu

      Affiliations

    • Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    • Corresponding Author InformationAddress requests for reprints to: Min-Sheng Zhu, PhD, or Xiang Gao, PhD, Model Animal Research Center, Nanjing University, 12 Xue-Fu Road, Pukou District, Nanjing 210061, China. fax: (86) 25-58641500.

Received 27 February 2008 ,Accepted 8 May 2008.

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 Supported by the MOST (2007CB947100), National Natural Science Funding of China (30570911), 973 program (2005CB522501), and grants from the National Institutes of Health (HL080536 and HL026043) and the Moss Heart Fund.

 W.-Q.H., Y.-J.P., and W.-C.Z. contributed equally to this work.

 All authors declare that they have no conflict of interest to disclose.

PII: S0016-5085(08)00852-4

doi: 10.1053/j.gastro.2008.05.032

Gastroenterology
Volume 135, Issue 2 , Pages 610-620.e2 , August 2008

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