Gastroenterology
Volume 135, Issue 2 , Pages 459-467 , August 2008

Sustained HBeAg and HBsAg Loss After Long-term Follow-up of HBeAg-Positive Patients Treated With Peginterferon α-2b

  • Erik H.C.J. Buster

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • ,
  • Hajo J. Flink

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • ,
  • Yilmaz Cakaloglu

      Affiliations

    • Department of Gastroenterohepatology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    • ,
  • Krzysztof Simon

      Affiliations

    • Department and Clinic of Infectious Diseases, Medical University Wroclaw, Wroclaw, Poland
    • ,
  • Jörg Trojan

      Affiliations

    • Department of Internal Medicine, Division of Gastroenterology, Johann Wolfgang Goethe University Medical Center, Frankfurt, Germany
    • ,
  • Fehmi Tabak

      Affiliations

    • Department of Infectious Diseases, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey
    • ,
  • Thomas M.K. So

      Affiliations

    • Department of Medicine, Princess Margaret Hospital, Hong Kong, China
    • ,
  • S. Victor Feinman

      Affiliations

    • Liver Disease Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    • ,
  • Tomasz Mach

      Affiliations

    • Department of Infectious Diseases and Hepatology, Jagiellonian University School of Medicine, Kraków, Poland
    • ,
  • Ulus S. Akarca

      Affiliations

    • Department of Gastroenterology, Ege University Faculty of Medicine, Izmir, Turkey
    • ,
  • Martin Schutten

      Affiliations

    • Department of Virology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • ,
  • Wanda Tielemans

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • ,
  • Anneke J. van Vuuren

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • ,
  • Bettina E. Hansen

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • ,
  • Harry L.A. Janssen

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    • Corresponding Author InformationAddress requests for reprints to: Harry L. A. Janssen, MD, PhD, Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 's Gravendijkwal 230, Room Ha204, 3015 CE Rotterdam, The Netherlands.

Received 7 January 2008 ,Accepted 8 May 2008.

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 Organized and sponsored by the Foundation for Liver Research (SLO) (Rotterdam, The Netherlands) and supported by Schering-Plough International (Kenilworth, NJ).

 E.H.C.J.B. has received speaker's honoraria from Novartis and Roche. S.V.F. has served as a consultant for Hoffman-La Roche and Schering-Plough and has received research support from Schering-Plough. H.L.A.J. has served as a consultant for Bristol-Myers Squibb, Gilead, Novartis, and Roche and has received research support from Bristol-Myers Squibb, Novartis, Roche, and Schering-Plough. The following authors have nothing to disclose: H.J.F., Y.C., K.S., J.T., F.T., T.M.K.S., T.M., U.S.A., M.S., W.T., A.J.V., and B.E.H. Potential investigator conflicts of interest have not been disclosed to study participants.

 Members of the HBV99-01 LTFU study group include the following: Belgium: F. Nevens, E. de Wit (University Hospital Gasthuisberg, Leuven); P. P. Michielsen, R. Braspenning (University Hospital, Antwerp); H. van Vlierberghe, A. de Geyter (University Hospital, Gent). Canada: E. J. Heathcote, D. Kaznowski (Toronto Western Hospital University Health Network, Toronto); S. Bojarski (Liver Disease Unit, Mount Sinai Hospital, Toronto). Denmark: L. R. Mathiesen, G. Kronborg, L. Rosenørn (Copenhagen University Hospital, Hvidovre). Germany: G. Gerken, S. Bein (University Hospital, Essen). Greece: G. Kitis (George Papanikolaou General Regional Hospital, Thessaloniki). Italy: G. B. Gaeta (Ospedale Gesù e Maria, Napoli); F. D'Antona, G. Montalto (Università di Palermo, Palermo). Malaysia: S. Sharmila (Hospital Selayang, Institute for Medical Research, Kuala Lumpur). The Netherlands: E. Verhey, G. Ramdjan, L. A. van Santen, A. Heijens, M. Ouwendijk, J. Francke, S. Diepstraten-Pas (Erasmus MC University Medical Center, Rotterdam); C. M. J. van Nieuwkerk, C. van Doorn (VU University Medical Center, Amsterdam); J. Drenth (University Medical Centre Radboud, Nijmegen); J. W. den Ouden-Muller (St Franciscus Hospital, Rotterdam); R. A. de Vries, P. van Embden (Rijnstate Hospital, Arnhem). Poland: R. Flisiak (Medical University of Białystok, Białystok). Singapore: R. Guan (Mount Elizabeth Medical Center, Singapore). Spain: M. Buti (Hospital General Universitari Pall d'Hebron, Barcelona); M. Rodriguez (Hospital Central de Asturias, Oviedo). Turkey: H. Simsek (Hacettepe University Faculty of Medicine, Ankara).

PII: S0016-5085(08)00850-0

doi: 10.1053/j.gastro.2008.05.031

Gastroenterology
Volume 135, Issue 2 , Pages 459-467 , August 2008

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