Gastroenterology
Volume 135, Issue 2 , Pages 632-641 , August 2008

Direct Activation of Cytosolic Ca2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells

  • John A. Murphy

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • David N. Criddle

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Mark Sherwood

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Michael Chvanov

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Rajarshi Mukherjee

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Euan McLaughlin

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • David Booth

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Julia V. Gerasimenko

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Michael G.T. Raraty

      Affiliations

    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Paula Ghaneh

      Affiliations

    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • John P. Neoptolemos

      Affiliations

    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Oleg V. Gerasimenko

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Alexei V. Tepikin

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Gary M. Green

      Affiliations

    • Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas
    • ,
  • Joseph R. Reeve Jr

      Affiliations

    • CURE: Digestive Diseases Research Centre, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California
    • Digestive Diseases Division, School of Medicine, University of California, Los Angeles, California
    • ,
  • Ole H. Petersen

      Affiliations

    • Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    • Corresponding Author InformationAddress reprint requests to: Professor Ole H. Petersen, FRS, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom. fax: (44) 151-794-5323.
    • ,
  • Robert Sutton

      Affiliations

    • Division of Surgery and Oncology, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom

Received 9 March 2007 ,Accepted 1 May 2008.

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⁎ J.A.M. and D.N.C. contributed equally to this work.

 This work was supported by Programme, Cooperative, and Component grants from the Medical Research Council (UK), and by National Institutes of Health grants DK 33850 (J.R.R.), and DK 37482 (G.M.G.), by the Veterans Administration Research Service, and by the National Institutes of Health CURE: Digestive Diseases Research Center grant DK41301. O.H.P. is a Medical Research Council Professor; J.M. was, and R.M. is, supported by an Amelie Waring Clinical Research Fellowship from CORE; and E.M. is supported by a Clinical Training Fellowship from the Royal College of Surgeons of England.

PII: S0016-5085(08)00780-4

doi: 10.1053/j.gastro.2008.05.026

Gastroenterology
Volume 135, Issue 2 , Pages 632-641 , August 2008

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