Gastroenterology
Volume 134, Issue 7 , Pages 1869-1881 , June 2008

Multigene Analysis Can Discriminate Between Ulcerative Colitis, Crohn's Disease, and Irritable Bowel Syndrome

  • Petra von Stein

      Affiliations

    • InDex Diagnostics AB, Stockholm, Sweden
    • Corresponding Author InformationAddress requests for reprints to: Petra von Stein, InDex Diagnostics AB, Retziuslaboriet, Karolinska Institutet, Scheeles väg 1, 17 177 Stockholm, Sweden. fax: (46) 8-508-847-39.
    • ,
  • Robert Lofberg

      Affiliations

    • Department of Medicine, Karolinska Institute and IBD Unit at Sophiahemmet, Stockholm, Sweden
    • ,
  • Nikolai V. Kuznetsov

      Affiliations

    • InDex Diagnostics AB, Stockholm, Sweden
    • ,
  • Alexander W. Gielen

      Affiliations

    • InDex Diagnostics AB, Stockholm, Sweden
    • ,
  • Jan–Olov Persson

      Affiliations

    • Statistical Consultancy, Mathematical Statistic, Stockholm University, Stockholm, Sweden
    • ,
  • Rolf Sundberg

      Affiliations

    • Statistical Consultancy, Mathematical Statistic, Stockholm University, Stockholm, Sweden
    • ,
  • Karin Hellstrom

      Affiliations

    • InDex Diagnostics AB, Stockholm, Sweden
    • ,
  • Anders Eriksson

      Affiliations

    • Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    • ,
  • Ragnar Befrits

      Affiliations

    • Gastroenterology and Hepatology Clinic, Karolinska University Hospital, Solna, Sweden
    • ,
  • Ake Ost

      Affiliations

    • Gastrointestinal Pathology, Aleris-Medilab AB, Täby and Karolinska Institute, Stockholm, Sweden
    • ,
  • Oliver D. von Stein

      Affiliations

    • InDex Diagnostics AB, Stockholm, Sweden

Received 5 September 2007 ,Accepted 28 February 2008.

References 

  1. Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369:1627–1640
  2. Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749–753
  3. Martland GT, Shepherd NA. Indeterminate colitis: definition, diagnosis, implications and a plea for nosological sanity. Histopathology. 2007;50:83–96
  4. Mitchell PJ, Rabau MJ, Haboubi NY. Indeterminate colitis. Tech Coloprocol. 2007;11:91–96
  5. Talley NJ. Irritable bowel syndrome. Intern Med J. 2006;36:724–728
  6. Bruining DH, Loftus EV. Evolving diagnostic strategies for inflammatory bowel disease. Curr Gastroenterol Rep. 2006;8:478–485
  7. Bossuyt X. Serologic markers in inflammatory bowel disease. Clin Chem. 2006;52:171–181
  8. Papadakis KA, Yang H, Ippoliti A, et al. Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations. Inflamm Bowel Dis. 2007;13:524–530
  9. Ferrante M, Henckaerts L, Joossens M, et al. New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut. 2007;56:1394–1403
  10. von Stein OD. Isolation of differentially expressed genes through subtractive suppression hybridization. Methods Mol Biol. 2001;175:263–278
  11. Flach CF, Eriksson A, Jennische E, et al. Detection of elafin as candidate biomarker for ulcerative colitis by whole genome microarray screening. Inflamm Bowel Dis. 2006;12:837–842
  12. Diatchenko L, Lau YC, Campbell AP, et al. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci U S A. 1996;93:6025–6030
  13. von Stein OD, Thiess WG, Hofman M. A high throughput screening for rarely transcribed differentially expressed genes. Nucleic Acids Res. 1997;25:2598–2602
  14. Wiklund I-M, Kuznetsov N, Lofberg R, et al. Identification of WASP and FKBP-like (WAFL) protein as a potential candidate gene in inflammatory bowel disease by subtractive suppression hybridization approach. Gut (submitted).
  15. Naes T, Isaksson T, Feran T, et al. A user friendly guide to multivariate calibration and classification. Chichester, UK: NIR Publications; 2002;
  16. Zweig MH, Campbel G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem. 1993;39:561–577
  17. Oxelmark L, Magnusson A, Löfberg R, et al. Group-based intervention program in inflammatory bowel disease patients: effects on quality of life. Inflamm Bowel Dis. 2007;13:182–190
  18. Sands BE. Inflammatory bowel disease: past, present, and future. J Gastroenterol. 2007;42:16–25
  19. Peltekova VD, Wintle RF, Rubin LA, et al. Functional variants of OCTN cation transporter genes are associated with Crohn's disease. Nat Genet. 2004;36:471–475
  20. Törkvist L, Noble CL, Lördal M, et al. Contribution of the IBD5 locus to Crohn's disease in the Swedish population. Scand J Gastroenterol. 2007;42:200–206
  21. Waller S, Tremelling M, Bredin F, et al. Evidence for association of OCTN genes and IBD5 with ulcerative colitis. Gut. 2006;55:809–814
  22. Lawrance IC, Fiocchi C, Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet. 2001;10:445–456
  23. Aronson PS. Role of SLC26-mediated Cl-/base exchange in proximal tubule NaCl transport. Novartis Found Symp. 2006;273:148–158
  24. Sugiura T, Kato Y, Kubo Y, et al. Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2. Drug Metab Pharmacokinet. 2006;21:375–383
  25. Silver DL, Wang N, Vogel S. Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem. 2003;278:28528–28532
  26. Galland F, Malergue F, Bazein H, et al. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. Genomics. 1998;53:203–213
  27. Berruyer C, Pouyet L, Millet V, et al. Vanin-1 licences inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. J Exp Med. 2006;203:2817–2827
  28. Zhang YW, Ding LS, Lai MD. Reg gene family and human diseases. World J Gastroenterol. 2003;9:2635–2641
  29. Hartupee JC, Zhang H, Bonaldo MF, et al. Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: RegIV. Biochim Biophys Acta. 2001;1518:287–293
  30. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev. 2007;8:221–233
  31. Verma RP, Hansch C. Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem. 2007;15:2223–2268
  32. Ravi A, Garg P, Sitaraman SV. Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?. Inflamm Bowel Dis. 2007;13:97–107
  33. Persson-Dajotoy T, Andersson P, Bjartell A, et al. Expression and production of the chemokine growth-related oncogene-alpha by human eosinophils. J Immunol. 2003;170:5309–5316
  34. Yang SK, Eckmann L, Panja A, et al. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology. 1997;113:1214–1223
  35. Mitsuyama K, Tsuruta O, Tomiyasu N, et al. Increased circulating concentrations of growth-related oncogene (GRO)-α in patients with inflammatory bowel disease. Dig Dis Sci. 2006;51:173–177
  36. Marks DJ, Harbord MW, MacAllister R, et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet. 2006;367:668–678
  37. Schmidt C, Giese T, Ludwig B, et al. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not ulcerative colitis. Inflamm Bowel Dis. 2005;11:16–23
  38. Fuss IJ, Becker C, Yang Z, et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL12 p40 monoclonal antibody. Inflamm Bowel Dis. 2006;12:9–15
  39. Rutgeerts P, Vermeire S, Van Assche G. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target?. Gut. 2007;56:453–455
  40. Jossens S, Reinisch W, Vermeire S, et al. The value of serological markers in indeterminate colitis: a prospective follow-up study. Gastroenterology. 2002;122:1242–1247
  41. Melmed GY, Elashoff R, Chen GC, et al. Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study. Clin Gastroenterol Hepatol. 2007;5:602–608
  42. Targan SR, Karp LC. Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the-art. Curr Opin Gastroenterol. 2007;23:390–394
  43. Sands BE. From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology. 2004;126:1518–1532

 Supported by a grant from the foundation for clinical research at Sophiahemmet, Stockholm, Sweden.

PII: S0016-5085(08)00418-6

doi: 10.1053/j.gastro.2008.02.083

Gastroenterology
Volume 134, Issue 7 , Pages 1869-1881 , June 2008

Article Tools

* Image Usage & Resolution