Gastroenterology
Volume 134, Issue 5 , Pages 1332-1341.e3 , May 2008

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

  • Liudmila L. Kodach

      Affiliations

    • Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Eliza Wiercinska

      Affiliations

    • Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Noel F.C.C. de Miranda

      Affiliations

    • Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Sylvia A. Bleuming

      Affiliations

    • Department of Experimental and Molecular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    • ,
  • Alex R. Musler

      Affiliations

    • Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands
    • ,
  • Maikel P. Peppelenbosch

      Affiliations

    • Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Evelien Dekker

      Affiliations

    • Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands
    • ,
  • Gijs R. van den Brink

      Affiliations

    • Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Carel J.M. van Noesel

      Affiliations

    • Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands
    • ,
  • Hans Morreau

      Affiliations

    • Department of Experimental and Molecular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    • ,
  • Daniel W. Hommes

      Affiliations

    • Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Peter ten Dijke

      Affiliations

    • Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • G. Johan A. Offerhaus

      Affiliations

    • Department of Pathology, University Medical Center, Utrecht, The Netherlands
    • ,
  • James C.H. Hardwick

      Affiliations

    • Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    • Corresponding Author InformationAddress requests for reprints to: James C. H. Hardwick, MD, PhD, Center for Experimental and Molecular Medicine, Room G2-105, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. fax: (31) 20-6977192.

Received 18 September 2006 ,Accepted 31 January 2008.

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 Supported by an EC FP6 grant for tumor host genomics (to E.W.) and the Dutch Cancer Society (L.L.K.).

 The authors report that there is no conflict of interest to disclose.

PII: S0016-5085(08)00347-8

doi: 10.1053/j.gastro.2008.02.059

Gastroenterology
Volume 134, Issue 5 , Pages 1332-1341.e3 , May 2008

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