Gastroenterology
Volume 134, Issue 5 , Pages 1316-1321 , May 2008

Eosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups

  • Robert C. Kapel

      Affiliations

    • Division of Gastroenterology, Danbury Hospital, Danbury, Connecticut
    • ,
  • Jocelyne K. Miller

      Affiliations

    • Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Carlos Torres

      Affiliations

    • Caris Diagnostics, Irving, Texas
    • ,
  • Saime Aksoy

      Affiliations

    • Caris Diagnostics, Irving, Texas
    • ,
  • Richard Lash

      Affiliations

    • Caris Diagnostics, Irving, Texas
    • ,
  • David A. Katzka

      Affiliations

    • Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Corresponding Author InformationAddress requests for reprints to: David A. Katzka, MD, Division of Gastroenterology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 3 Ravdin Building, Philadelphia, Pennsylvania 19104. fax: (215) 349-5915.

Received 2 May 2007 ,Accepted 29 January 2008.

References 

  1. Winter HS, Madara JL, Stafford RJ, et al. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology. 1982;83:818–823
  2. Attwood SE, Smyrk TC, Demeester TR, et al. Esophageal eosinophilia with dysphagia (A distinct clinicopathologic syndrome). Dig Dis Sci. 1993;38:109–116
  3. Vitellas KM, Bennett WF, Bova JG, et al. Idiopathic eosinophilic esophagitis. Radiology. 1993;186:789–793
  4. Akei HS, Mishra A, Blanchard C, et al. Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology. 2005;129:985–994
  5. Blanchard C, Wang N, Rothenberg ME. Eosinophilic esophagitis: pathogenesis, genetics, and therapy. J Allergy Clin Immunol. 2006;118:1054–1059
  6. Sgouros SN, Bergele C, Mantides A. Eosinophilic esophagitis in adults: a systematic review. Eur J Gastroenterol Hepatol. 2006;18:211–217
  7. Parfitt JR, Gregor JC, Suskin NG, et al. Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients. Mod Pathol. 2006;19:90–96
  8. Potter JW, Saeian K, Staff D, et al. Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features. Gastrointest Endosc. 2004;59:355–361
  9. Liacouras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3:1198–1206
  10. Croese J, Fairley SK, Masson JW, et al. Clinical and endoscopic features of eosinophilic esophagitis in adults. Gastrointest Endosc. 2003;58:516–522
  11. Remedios M, Campbell C, Jones DM, et al. Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc. 2006;63:3–12
  12. Sant'Anna AM, Rolland S, Fournet JC, et al. Eosinophilic esophagitis in children: symptoms, histology and pH probe results. J Pediatr Gastroenterol Nutr. 2004;39:373–377
  13. Cuzick J. A Wilcoxon-type test for trend. Stat Med. 1985;4:87–89
  14. Assa'ad AH, Putnam PE, Collins MH, et al. Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol. 2007;119:731–738
  15. Blanchard C, Wang N, Stringer KF, et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. Am Soc Clin Invest. 2006;116:536–547
  16. Steiner SJ, Gupta SK, Croffie JM, et al. Correlation between number of eosinophils and reflux index on same day esophageal biopsy and 24 hour esophageal pH monitoring. Am J Gastroenterol. 2004;99:801–805
  17. Cherian S, Smith NM, Forbes DA. Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia. Arch Dis Childhood. 2006;91:1000–1004
  18. Gonsalves N, Pollicarpio-Nicolas M, Zhang Q, et al. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc. 2006;64:313–319

 Dr. Kapel is a consultant to Caris Diagnostics.

 R.C.K. and J.K.M. are both first authors.

PII: S0016-5085(08)00248-5

doi: 10.1053/j.gastro.2008.02.016

Gastroenterology
Volume 134, Issue 5 , Pages 1316-1321 , May 2008

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