Gastroenterology
Volume 134, Issue 4 , Pages 975-980 , April 2008

The Natural History of Small-Duct Primary Sclerosing Cholangitis

  • Einar Björnsson

      Affiliations

    • Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
    • Corresponding Author InformationAddress requests for reprints to: Einar Björnsson, MD, Department of Internal Medicine, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden. fax: (46) 31822152.
    • ,
  • Rolf Olsson

      Affiliations

    • Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
    • ,
  • Annika Bergquist

      Affiliations

    • Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Stefan Lindgren

      Affiliations

    • Malmo University Hospital, Malmo, Sweden
    • ,
  • Barbara Braden

      Affiliations

    • John Radcliffe Hospital, Oxford, United Kingdom
    • ,
  • Roger W. Chapman

      Affiliations

    • John Radcliffe Hospital, Oxford, United Kingdom
    • ,
  • Kirsten M. Boberg

      Affiliations

    • Rikshospitalet, Oslo, Norway
    • ,
  • Paul Angulo

      Affiliations

    • Department of Medicine, Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota

Received 23 September 2007 ,Accepted 10 January 2008.

References 

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  2. Wiesner RH, Grambsch PM, Dickson ER, et al. Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis. Hepatology. 1989;10:430–436
  3. Farrant JM, Hayllar KM, Wilkinson ML, et al. Natural history and prognostic variables in primary sclerosing cholangitis. Gastroenterology. 1991;100:1710–1717
  4. Dickson ER, Murtaugh PA, Wiesner RH, et al. Primary sclerosing cholangitis: refinement and validation of survival models. Gastroenterology. 1992;103:1893–1901
  5. Broomé U, Olsson R, Lööf L, et al. Natural history and prognostic factors in 305 patients with primary sclerosing cholangitis. Gut. 1996;38:610–615
  6. Okolicsanyi L, Fabris L, Viaggi S, et al. Primary sclerosing cholangitis: clinical presentation, natural history and prognostic variables: an Italian multicentre study (The Italian PSC Study Group). Eur J Gastroenterol Hepatol. 1996;8:685–691
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  9. Wee A, Ludwig J, Coffey RJ, et al. Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hum Pathol. 1985;16:719–726
  10. Björnsson E, Boberg KM, Cullen S, et al. Patients with small duct primary sclerosing cholangitis have a favorable long-term prognosis. Gut. 2002;51:731–735
  11. Broomé U, Glaumann H, Lindstöm E, et al. Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC). J Hepatol. 2002;36:586–589
  12. Angulo P, Maor-Kendler Y, Lindor KD. Small-duct primary sclerosing cholangitis:prevalence and natural history. Hepatology. 2002;35:1494–1500
  13. Nikolaidis NL, Giouleme OI, Tziomalos KA, et al. Small-duct primary sclerosing cholangitis (A single-center seven-year experience). Dig Dis Sci. 2005;50:324–326
  14. Alvarez F, Berg PA, Bianchi FR, et al. International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929–938
  15. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  16. Wiesner RH, LaRusso NF. Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology. 1980;79:200–206
  17. Riordan SM, Williams R. Risk of cholangiocarcinoma in primary sclerosing cholangitis. In:  Manns MP,  Chapman RW,  Stiehl A editor. Primary sclerosing cholangitis. London: Kluwer Academic Publishers; 1997;p. 55–68
  18. Rasmussen HH, Fallingborg JF, Mortensen PB, et al. Hepatobiliary dysfunction and primary sclerosing cholangitis in patients with Crohn’s disease. Scand J Gastroenterol. 1997;32:604–610

 Conflicts of interest: The authors have no conflicts of interest.

PII: S0016-5085(08)00116-9

doi: 10.1053/j.gastro.2008.01.042

Gastroenterology
Volume 134, Issue 4 , Pages 975-980 , April 2008

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