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Gastroenterology
Volume 134, Issue 1
, Pages 120-130
, January 2008
Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis
References
- . ras genes. Annu Rev Biochem. 1987;56:779–827
- . ras oncogenes in human cancer: a review. Cancer Res. 1989;49:4682–4689
- . The ras gene family and human carcinogenesis. Mutat Res. 1988;195:255–271
- . Signal transduction (The hunt for Ras targets). Nature. 1994;370:508–509
- The activation of phosphatidylinositol 3-kinase by Ras. Curr Biol. 1994;4:798–806
- . RAS oncogenes: the first 30 years. Nat Rev Cancer. 2003;3:459–465
- . Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv. 1996;27:101–125
- . Ras effectors. Curr Opin Cell Biol. 1996;8:197–204
- . Ras target proteins in eukaryotic cells. FASEB J. 1995;9:1311–1318
- Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549–554
- KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res. 1988;16:7773–7782
- Activation of c-K-ras mutations in human gastrointestinal tumors. Gastroenterology. 2000;118:1045–1050
- Prevalence of ras gene mutations in human colorectal cancers. Nature. 1987;327:293–297
- Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319:525–532
- . K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. Cancer Res. 2001;61:2670–2675
- Endogenous oncogenic K-ras (G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004;5:375–387
- Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature. 2001;410:1111–1116
- Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell. 2003;4:111–120
- Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology. 2002;123:492–504
- The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. BioEssays. 2007;29:549–557
- Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 2005;15:92–96
- . The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol. 2000;32:1103–1121
- . Sp1- and Krüppel-like transcription factors. Genome Biol. 2003;4:206;1–206.8
- A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res. 1999;27:1263–1270
- . Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. J Biol Chem. 2001;276:6897–6900
- Krüppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res. 2006;34:1216–1223
- KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer. 2006;118:1346–1355
- . Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene. Mol Cell Biol. 2001;21:562–574
- Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett. 2005;579:4757–4762
- Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene. 2004;23:3404–3413
- Mutations of the BRAF gene in human cancer. Nature. 2002;417:949–954
- K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997;11:2468–2481
- K-ras is essential for the development of the mouse embryo. Oncogene. 1997;15:1151–1159
- All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Krüppel-like factor 5. FEBS Lett. 2004;578:99–105
- Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. Clin Cancer Res. 2006;12:2442–2448
- K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers. Anticancer Res. 1996;16:3839–3844
- Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prev. 2000;9:1193–1197
- Prognostic role of K-ras in patients with progressive colon cancer who received treatment with Marimastat (BB2516). Cancer Invest. 2000;18:185–190
- Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer. Clin Colorectal Cancer. 2001;1:110–116
- Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem. 2004;279:12093–12101
- Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A. 2006;103:14122–14127
- Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001;15:3243–3248
- . Physiological analysis of oncogenic K-ras. Methods Enzymol. 2005;407:676–690
Supported in part by National Institutes of Health grants DK52230, DK64399, DK76742, and CA84197.
The authors report that no conflicts of interest exist.
PII: S0016-5085(07)01849-5
doi: 10.1053/j.gastro.2007.10.023
© 2008 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 134, Issue 1
, Pages 120-130
, January 2008

