Gastroenterology
Volume 134, Issue 1 , Pages 156-165.e1 , January 2008

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

  • Eoin P. Cummins

      Affiliations

    • UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    • E.P.C., P.G.F., and C.T.T. contributed equally to this study.
    • ,
  • Fergal Seeballuck

      Affiliations

    • UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    • Sigmoid Biotechnologies, Dublin, Ireland
    • ,
  • Stephen J. Keely

      Affiliations

    • Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    • ,
  • Niamh E. Mangan

      Affiliations

    • Institute of Molecular Medicine, St James’s Hospital, Trinity College Dublin, Dublin, Ireland
    • ,
  • John J. Callanan

      Affiliations

    • UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    • ,
  • Padraic G. Fallon

      Affiliations

    • Institute of Molecular Medicine, St James’s Hospital, Trinity College Dublin, Dublin, Ireland
    • E.P.C., P.G.F., and C.T.T. contributed equally to this study.
    • ,
  • Cormac T. Taylor

      Affiliations

    • UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    • E.P.C., P.G.F., and C.T.T. contributed equally to this study.
    • Corresponding Author InformationAddress requests for reprints to: Cormac T. Taylor, PhD, UCD Conway Institute, School of Medicine and Medical Science, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland. fax: (353) 1-716-6701.

Received 9 May 2007 ,Accepted 27 September 2007.

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 Supported by grants from the Science Foundation Ireland, the Wellcome Trust, the Health Research Board of Ireland, and the Irish Higher Education Authority Programme for Research in Third Level Institutions. We thank Brian Cloak for imaging expertise.

PII: S0016-5085(07)01811-2

doi: 10.1053/j.gastro.2007.10.012

Gastroenterology
Volume 134, Issue 1 , Pages 156-165.e1 , January 2008

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