Gastroenterology
Volume 134, Issue 1 , Pages 226-238, January 2008

Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription

  • Sohji Nishina

      Affiliations

    • Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Keisuke Hino

      Affiliations

    • Department of Basic Laboratory Sciences, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • Corresponding Author InformationAddress requests for reprints to: Keisuke Hino, MD, PhD, Department of Basic Laboratory Sciences, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. fax: (81) 836-222824.
    • ,
  • Masaaki Korenaga

      Affiliations

    • Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Chiara Vecchi

      Affiliations

    • Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    • ,
  • Antonello Pietrangelo

      Affiliations

    • Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    • ,
  • Yoichi Mizukami

      Affiliations

    • Center for Gene Research, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Takakazu Furutani

      Affiliations

    • Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Aya Sakai

      Affiliations

    • Department of Basic Laboratory Sciences, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Michiari Okuda

      Affiliations

    • Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Isao Hidaka

      Affiliations

    • Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    • ,
  • Kiwamu Okita

      Affiliations

    • Department of Gastroenterology and Hepatology, Shimonoseki Kohsei Hospital, Yamaguchi, Japan
    • ,
  • Isao Sakaida

      Affiliations

    • Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan

Received 3 May 2007; accepted 27 September 2007. published online 11 October 2007.

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 The authors report that no conflicts of interest exist.

 Supported by grants from the Ministry of Education, Culture, Sports, Science and Technology (15590653 and 18590736) and in part by the Ministry of Health, Labor and Welfare, Japan, and by a grant from EEC Framework 6 (LSHM-CT-2006-037296 EuroIron1).

PII: S0016-5085(07)01810-0

doi:10.1053/j.gastro.2007.10.011

Refers to article:

  • HCV, Iron, and Oxidative Stress: The New Choreography of Hepcidin

    Debbie Trinder, Oyekoya T. Ayonrinde, John K. Olynyk
    Gastroenterology January 2008 (Vol. 134, Issue 1, Pages 348-351)

Gastroenterology
Volume 134, Issue 1 , Pages 226-238, January 2008

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