Gastroenterology
Volume 134, Issue 1 , Pages 131-144 , January 2008

γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells

  • Takashi Akiyoshi

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Masafumi Nakamura

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Kosuke Yanai

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Shuntaro Nagai

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Junji Wada

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Kenichiro Koga

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Hiroshi Nakashima

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Norihiro Sato

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Masao Tanaka

      Affiliations

    • Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Mitsuo Katano

      Affiliations

    • Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • Corresponding Author InformationAddress requests for reprints to: Mitsuo Katano, MD, Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. fax: (81) 92-642-6221.

Received 4 January 2007 ,Accepted 27 September 2007.

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 The authors report that no conflicts of interest exist.

 Supported by General Scientific Research Grants (17591414, 18390350, 18659372, and 18591468) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. The Notch2 monoclonal antibody developed by Spyros Artavanis-Tsakonas was obtained from the University of Iowa Developmental Hybridoma Studies bank.

PII: S0016-5085(07)01807-0

doi: 10.1053/j.gastro.2007.10.008

Gastroenterology
Volume 134, Issue 1 , Pages 131-144 , January 2008

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