Gastroenterology
Volume 134, Issue 1 , Pages 215-225, January 2008

Roles of Calcitonin Gene–Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing and Angiogenesis

  • Takashi Ohno

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Isehara Kyodo Hospital, Isehara, Kanagawa
    • ,
  • Youichiro Hattori

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa
    • ,
  • Rie Komine

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • ,
  • Takako Ae

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa
    • ,
  • Sumito Mizuguchi

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa
    • ,
  • Katsuharu Arai

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • ,
  • Takeo Saeki

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • ,
  • Tatsunori Suzuki

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa
    • ,
  • Kanako Hosono

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • ,
  • Izumi Hayashi

      Affiliations

    • Department of Pathophysiology, Nippon Pharmaceutical University, Ina, Saitama, Tokyo, Japan
    • ,
  • Yoshio Oh–Hashi

      Affiliations

    • Isehara Kyodo Hospital, Isehara, Kanagawa
    • ,
  • Yukiko Kurihara

      Affiliations

    • Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, Tokyo University, Tokyo, Japan
    • ,
  • Hiroki Kurihara

      Affiliations

    • Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, Tokyo University, Tokyo, Japan
    • ,
  • Kikuko Amagase

      Affiliations

    • Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    • ,
  • Susumu Okabe

      Affiliations

    • Department of Pharmacology, Doshisha Women’s College, Kyoto, Japan
    • ,
  • Katsunori Saigenji

      Affiliations

    • Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • ,
  • Masataka Majima

      Affiliations

    • Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa
    • Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa
    • Corresponding Author InformationAddress requests for reprints to: Masataka Majima, MD, Kitasato University School of Medicine, Kanagawa, 228-8555, Japan. fax: (81) 42-778-7604.

Received 6 November 2006; accepted 20 September 2007. published online 08 October 2007.

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 The authors thank Michiko Ogino and Osamu Katsumata for technical assistance. This work was supported by research grants (#12470529 and #12670094), by a High-tech Research Center grant, by an Academic Frontier Project grant, and by a grant from The 21st Century COE Program, from the Ministry of Education, Culture, Sports, Science and Technology. This study was also supported by an Integrative Research Program of the Graduate School of Medical Science, Kitasato University. We are also grateful to Mr. C.W.P. Reynolds for linguistic assistance in the preparation of the manuscript.

PII: S0016-5085(07)01798-2

doi:10.1053/j.gastro.2007.10.001

Gastroenterology
Volume 134, Issue 1 , Pages 215-225, January 2008

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