Gastroenterology
Volume 133, Issue 5 , Pages 1458-1465 , November 2007

Predictive Factors for Reactivation of Hepatitis B Following Hepatitis B e Antigen Seroconversion in Chronic Hepatitis B

  • Chia–Ming Chu

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Chia-Ming Chu, MD, Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 10591, Taiwan. fax: (886) 3-3272236.
    • ,
  • Yun–Fan Liaw

Received 12 April 2007 ,Accepted 2 August 2007.

References 

  1. Chu CM, Liaw YF. Natural history differences in perinatally versus adult-acquired disease. Curr Hepat Rep. 2004;3:123–131
  2. Chu CM, Karayiannis P, Fowler MJ, et al. Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum. Hepatology. 1985;5:431–434
  3. Chu CM. Natural history of chronic hepatitis B virus infection in adults with emphasis on the occurrence of cirrhosis and hepatocellular carcinoma. J Gastroenterol Hepatol. 2000;15(Suppl):E25–E30
  4. Liaw YF, Tai DI, Chu CM, et al. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology. 1988;8:493–496
  5. Fattovich G, Brollo L, Giustina G, et al. Natural history and prognostic factors for chronic hepatitis type B. Gut. 1991;32:294–298
  6. Hsu YS, Chien RN, Yeh CT, et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology. 2002;35:1522–1527
  7. Chu CM, Hung SJ, Lin J, et al. Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med. 2004;116:829–834
  8. Chu CM, Liaw YF. HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up. Hepatology. 2007;45:1187–1192
  9. Chu CM, Liaw YF. Spontaneous relapse of hepatitis in inactive HBsAg carriers from Taiwan. Hepatol Int. 2007;1:311–315
  10. Chu CM, Liaw YF. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol. 2005;43:411–417
  11. Chu CJ, Hussain M, Lok AS. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology. 2002;122:1756–1762
  12. Kao JH, Chen PJ, Lai MY, et al. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol. 2004;72:363–369
  13. Lin DY, Sheen IS, Chiu CT, et al. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound. 1993;21:303–308
  14. Daly LE, Bourke GL. Interpretation and uses of medical statistics. London: Blackwell Science; 2000;
  15. Gish RG, Locarnini SA. Chronic hepatitis B: current testing strategies. Clin Gastroenterol Hepatol. 2006;4:666–676
  16. Kao JH, Chen PJ, Lai MY, et al. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology. 2000;118:554–559
  17. Chu CM, Liaw YF, Sheen IS, et al. Sex difference in chronic hepatitis B virus infection: an appraisal based on the status of hepatitis B e antigen and antibody. Hepatology. 1983;3:947–950
  18. Chu CM, Liaw YF, Chen TJ, et al. Comparison between HBeAg-positive and anti-HBe-positive chronic type B hepatitis. Chin J Gastroenterol. 1985;2:136–141
  19. Chu CM, Sheen IS, Lin SM, et al. Sex difference in chronic hepatitis B virus infection: studies of serum HBeAg and alanine aminotransferase levels in 10,431 asymptomatic Chinese HBsAg carriers. Clin Infect Dis. 1993;16:709–713
  20. Liaw YF. Hepatitis flares and hepatitis B e antigen seroconversion: implication in anti-hepatitis B virus therapy. J Gastroenterol Hepatol. 2003;18:246–252
  21. Chu CM, Liaw YF. Chronic hepatitis B virus infection acquired in childhood: special emphasis on prognostic and therapeutic implication of delayed HBeAg seroconversion. J Viral Hepat. 2007;14:147–152
  22. Iloeje UH, Yang HI, Su J, et al. Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-In HBV (the REVEAL-HBV) Study Group Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology. 2006;130:678–686
  23. Chen CJ, Yang HI, Su J, et al. REVEAL-HBV Study Group Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006;295:65–73
  24. Funk ML, Rosenberg DM, Lok AS. World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants. J Viral Hepat. 2002;9:52–61

 Supported by a grant from National Science of Council of Taiwan.

 The authors have no potential conflicts of interest to report.

PII: S0016-5085(07)01495-3

doi: 10.1053/j.gastro.2007.08.039

Gastroenterology
Volume 133, Issue 5 , Pages 1458-1465 , November 2007

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