Gastroenterology
Volume 133, Issue 5 , Pages 1487-1498 , November 2007

Microbial Mannan Inhibits Bacterial Killing by Macrophages: A Possible Pathogenic Mechanism for Crohn’s Disease

  • Chiedzo M. Mpofu

      Affiliations

    • Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Barry J. Campbell

      Affiliations

    • Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Sreedhar Subramanian

      Affiliations

    • Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Stuart Marshall–Clarke

      Affiliations

    • Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
    • ,
  • C. Anthony Hart

      Affiliations

    • Medical Microbiology, School of Host Defence and Infection, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Andy Cross

      Affiliations

    • Cell Regulation and Signalling Division, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Carol L. Roberts

      Affiliations

    • Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    • ,
  • Adrian McGoldrick

      Affiliations

    • Veterinary Laboratories Agency, Starcross, Devon, United Kingdom
    • ,
  • Steven W. Edwards

      Affiliations

    • Cell Regulation and Signalling Division, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    • S.W.E. and J.M.R. contributed equally to this paper.
    • ,
  • Jonathan M. Rhodes

      Affiliations

    • Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    • S.W.E. and J.M.R. contributed equally to this paper.
    • Corresponding Author InformationAddress requests for reprints to: Jonathan M. Rhodes, MD, Professor, School of Clinical Science, University of Liverpool, Liverpool L69 3GA, United Kingdom. fax (44) 151-706 5802.

Received 29 November 2006 ,Accepted 19 July 2007.

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 Supported by Clinical Research fellowships awarded by CORE (the Digestive Disorders Foundation) and the Medical Research Council (award number G84/6152 to C.M.), by a Clinical Research Fellowship from the National Association for Colitis and Crohn’s disease (M/03/2; to S.S.), and by the Wellcome Trust 4-year PhD program in Cellular and Molecular Physiology (074949/Z/04/Z; to C.R.).Conflict of interests: J.M.R. is a past/present member of advisory boards for Procter and Gamble, Schering-Plough, Chiesi, Falk, and Celltech/UCB and, with the University of Liverpool and Provexis UK, holds a patent for use of a soluble fiber preparation as maintenance therapy for Crohn’s disease. No other authors have any potential conflicts of interest.

PII: S0016-5085(07)01450-3

doi: 10.1053/j.gastro.2007.08.004

Gastroenterology
Volume 133, Issue 5 , Pages 1487-1498 , November 2007

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