Gastroenterology
Volume 133, Issue 4 , Pages 1086-1092 , October 2007

Colonoscopic Screening of First-Degree Relatives of Patients With Large Adenomas: Increased Risk of Colorectal Tumors

  • Vanessa Cottet

      Affiliations

    • INSERM Unité 866, Dijon, France
    • Université de Bourgogne, Dijon, France
    • ,
  • Alexandre Pariente

      Affiliations

    • Centre Hospitalier, Pau, France
    • ,
  • Bernard Nalet

      Affiliations

    • Centre Hospitalier, Montélimar, France
    • ,
  • Jacques Lafon

      Affiliations

    • Centre Hospitalier, Aix-en-Provence, France
    • ,
  • Chantal Milan

      Affiliations

    • INSERM Unité 866, Dijon, France
    • Université de Bourgogne, Dijon, France
    • ,
  • Sylviane Olschwang

      Affiliations

    • INSERM Unité 599, Marseille, France
    • Université d’Aix-Marseille 2, Marseille, France
    • ,
  • Catherine Bonaiti–Pellié

      Affiliations

    • INSERM Unité 535, Villejuif, France
    • Université de Paris-Sud, Villejuif, France
    • ,
  • Jean Faivre

      Affiliations

    • INSERM Unité 866, Dijon, France
    • Université de Bourgogne, Dijon, France
    • Centre Hospitalier Universitaire, Dijon, France
    • ,
  • Claire Bonithon–Kopp

      Affiliations

    • INSERM Unité 866, Dijon, France
    • Université de Bourgogne, Dijon, France
    • INSERM, CIE1, Centre d’Investigation Clinique – Epidémiologie Clinique/Essais Cliniques, Dijon, France
    • Centre Hospitalier Universitaire, Dijon, France
    • Corresponding Author InformationAddress requests for reprints to: Claire Bonithon-Kopp, MD, PhD, INSERM Unité 866, Faculté de Médecine, BP 87900, 21079 Dijon Cedex, France. fax: (33) 3-80-66-82-51.
    • ,
  • ANGH Group

Received 22 December 2006 ,Accepted 16 July 2007.

References 

  1. Bouvier AM, Remontet L, Jougla E, et al. Incidence of gastrointestinal cancers in France. Gastroenterol Clin Biol. 2004;28:877–881
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  3. Jorgensen OD, Kronborg O, Fenger C. The Funen Adenoma Follow-up Study (Incidence and death from colorectal carcinoma in an adenoma surveillance program). Scand J Gastroenterol. 1993;28:869–874
  4. Winawer SJ, Zauber AG, Ho MN, et al. The National Polyp Study Workgroup Prevention of colorectal cancer by colonoscopic polypectomy. N Engl J Med. 1993;329:1977–1981
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  7. Pariente A, Milan C, Lafon J, et al. The Association Nationale des Gastroenterologues des Hopitaux and Registre Bourguignon des Cancers Digestifs (INSERM CRI 9505) Colonoscopic screening in first-degree relatives of patients with ‘sporadic’ colorectal cancer: a case-control study. Gastroenterology. 1998;115:7–12
  8. Lievre A, Milet J, Carayol J, et al. Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC Cancer. 2006;6:270
  9. Cottet V, Pariente A, Nalet B, et al. Low compliance with colonoscopic screening in first-degree relatives of patients with large adenomas. Aliment Pharmacol Ther. 2006;24:101–109
  10. Ahsan H, Neugut AI, Garbowski GC, et al. Family history of colorectal adenomatous polyps and increased risk for colorectal cancer. Ann Intern Med. 1998;128:900–905
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  18. Endoscopie digestive basse: indications en dehors du dépistage en population. Agence Nationale d’Accréditation et d’Evaluation en Santé, 2004. Available at http://www.hassante.fr/portail/upload/docs/application/pdf/endoscopie_2004_recommandations_mise_en_forme_2006.pdf (Accessed August 21, 2007)
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 Supported by grants from the French National Society of Gastroenterology, the Ligue Nationale contre le Cancer (France), the Association pour la Recherche sur le Cancer, the Regional Council of Burgundy, the Fondation de France, and the French Ministry of Health (PHRC).

 All authors state that there is no conflict of interest to disclose.

 Members of the ANGH Group include P. Berthelémy (Pau), P. Cassan (Vichy), M. Glikmanas (Meaux), G. Gatineau-Sailliant (Meaux), A. Courrier (Metz), D. Pillon (Bourg-en-Bresse), J. P. Michalet (Beaune), J. P. Latrive (Compiègne), J. Guillan (Evreux), A. Blanchi (Le Mans), B. Bour (Le Mans), T. Morin (Tarbes), F. Druart (Tarbes), J. L. Legoux (Orléans), D. Labarrière (Orléans), B. Naudy (Toulon), D. Goldfain (Dreux), A. Rotenberg (Dreux), C. Bories (Beauvais), J. Andrieu (Le Chesnay), J. Doll (Le Chesnay), and J. L. Staub (Niort).

PII: S0016-5085(07)01403-5

doi: 10.1053/j.gastro.2007.07.023

Gastroenterology
Volume 133, Issue 4 , Pages 1086-1092 , October 2007

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