« Previous
Next »
Gastroenterology
Volume 133, Issue 2
, Pages 706-709
, August 2007
Teaching Tolerance With a Probiotic Antigen Delivery System
References
- . Immune privilege in the gut: the establishment and maintenance of non-responsiveness to dietary antigens and commensal flora. Immunol Rev. 2006;213:82–100
- . Oral tolerance and allergic responses to food proteins. Curr Opin Allergy Clin Immunol. 2006;6:207–213
- . The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117:514–521
- . Oral tolerance. Immunol Rev. 2005;206:232–259
- . Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci U S A. 1994;91:6688–6692
- Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995;376:177–180
- Lymphocytes from orally tolerized mice display enhanced susceptibility to death by apoptosis when cultured in the absence of antigen in vitro. Am J Pathol. 1996;149:1971–1979
- . Natural regulatory T cells: mechanisms of suppression. Trends Mol Med. 2007;13:108–116
- Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein (II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes). J Immunol. 1989;142:748–752
- Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer’s patches of SJL mice. Cell Immunol. 1994;157:439–447
- Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A. 1992;89:421–425
- . Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003;3:253–257
- A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997;389:737–742
- Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J Exp Med. 2002;196:505–515
- . Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007;8:457–462
- . Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005;6:345–352
- Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C (B-17 scid mice). Int Immunol. 1993;5:1461–1471
- The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc Natl Acad Sci U S A. 1990;87:2433–2437
- Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995;3:521–530
- Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 1993;75:253–261
- . Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J Immunol. 2001;167:188–195
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235–238
- Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol. 2004;172:5149–5153
- Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198:1875–1886
- Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin. Gastroenterology. 2007;133:517–528
- Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science. 2000;289:1352–1355
- Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J Exp Med. 2002;196:1017–1024
- Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein. Gastroenterology. 2007;133:(in press)
- A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn’s disease. Clin Gastroenterol Hepatol. 2006;4:754–759
- . Probiotics and chronic disease. J Clin Gastroenterol. 2006;40:270–274
- Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy. Vaccine. 2003;22:87–95
- Lactic acid bacteria inhibit TH2 cytokine production by mononuclear cells from allergic patients. J Allergy Clin Immunol. 2002;110:617–623
- Oral administration of recombinant Lactococcus lactis expressing bovine beta-lactoglobulin partially prevents mice from sensitization. Clin Exp Allergy. 2005;35:539–546
- Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response. Immunity. 2006;25:655–664
- . Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature. 2006;440:808–812
- Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol. 2001;2:361–367
- CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005;307:254–258
- The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis. J Immunol. 2002;168:900–908
PII: S0016-5085(07)01287-5
doi: 10.1053/j.gastro.2007.06.055
© 2007 AGA Institute. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 133, Issue 2
, Pages 706-709
, August 2007

