Gastroenterology
Volume 133, Issue 3 , Pages 808-817 , September 2007

Neuropeptide S Receptor 1 Gene Polymorphism Is Associated With Susceptibility to Inflammatory Bowel Disease

  • Mauro D’Amato

      Affiliations

    • Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    • Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationAddress requests for reprints to: Mauro D’Amato, PhD, Department of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, 14157 Stockholm, Sweden. fax: (46) 8-7745538.
    • ,
  • Sara Bruce

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Francesca Bresso

      Affiliations

    • Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    • Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Marco Zucchelli

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Sini Ezer

      Affiliations

    • Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    • Folkhalsan Institute of Genetics, Helsinki, Finland
    • ,
  • Ville Pulkkinen

      Affiliations

    • Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    • ,
  • Cecilia Lindgren

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Marco Astegiano

      Affiliations

    • Clinic of Gastrohepatology DU, Molinette Hospital, Torino, Italy
    • ,
  • Mario Rizzetto

      Affiliations

    • Clinic of Gastrohepatology DU, Molinette Hospital, Torino, Italy
    • ,
  • Paolo Gionchetti

      Affiliations

    • Division of Internal Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy
    • ,
  • Gabriele Riegler

      Affiliations

    • Gastroenterology Unit, 2nd University of Naples, Naples, Italy
    • ,
  • Raffaello Sostegni

      Affiliations

    • Gastroenterology Division, ASO Ordine Mauriziano, Torino, Italy
    • ,
  • Marco Daperno

      Affiliations

    • Gastroenterology Division, ASO Ordine Mauriziano, Torino, Italy
    • ,
  • Sandra D’Alfonso

      Affiliations

    • Department of Medical Sciences, University of Eastern Piedmont and IRCAD, Novara, Italy
    • ,
  • Patricia Momigliano–Richiardi

      Affiliations

    • Department of Medical Sciences, University of Eastern Piedmont and IRCAD, Novara, Italy
    • ,
  • Leif Torkvist

      Affiliations

    • Division of Colorectal Surgery, IBD Unit, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Pauli Puolakkainen

      Affiliations

    • Department of Surgery, University of Helsinki, Helsinki, Finland
    • ,
  • Maarit Lappalainen

      Affiliations

    • Department of Medicine, University of Helsinki, Helsinki, Finland
    • Research program for Molecular Medicine, Biomedicum Helsinki, Helsinki, Finland
    • ,
  • Paulina Paavola–Sakki

      Affiliations

    • Department of Medicine, University of Helsinki, Helsinki, Finland
    • Department of Gastroenterology, University of Helsinki, Helsinki, Finland
    • ,
  • Leena Halme

      Affiliations

    • Department of Transplantation and Liver Surgery, University of Helsinki, Helsinki, Finland
    • ,
  • Martti Farkkila

      Affiliations

    • Department of Gastroenterology, University of Helsinki, Helsinki, Finland
    • ,
  • Ulla Turunen

      Affiliations

    • Department of Gastroenterology, University of Helsinki, Helsinki, Finland
    • ,
  • Kimmo Kontula

      Affiliations

    • Department of Medicine, University of Helsinki, Helsinki, Finland
    • ,
  • Robert Lofberg

      Affiliations

    • IBD Unit, HMQ Sophia Hospital, Stockholm, Sweden
    • Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Sven Pettersson

      Affiliations

    • Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    • Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    • Genome Institute of Singapore, Singapore
    • ,
  • Juha Kere

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    • Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    • Folkhalsan Institute of Genetics, Helsinki, Finland
    • J.K. is co-inventor on a patent application on NPSR1 (GPR154) owned by GenOs Ltd (Helsinki, Finland), and is a minority shareholder and member of the board of directors of GeneOs Ltd.

Received 20 August 2006 ,Accepted 25 May 2007.

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 Supported by funds from the Sigrid Jusélius Foundation (J.K. and K.K.), the Päivikki and Sakari Sohlberg Foundation and Academy of Finland (J.K. and K.K.), the Swedish Research Council (J.K. and S.P.), Italian Ministry of University and Research (PRIN project) (S.D. and P.M.-R.), and the KiiM Network (grant 2006 to M.D.).

PII: S0016-5085(07)01152-3

doi: 10.1053/j.gastro.2007.06.012

Gastroenterology
Volume 133, Issue 3 , Pages 808-817 , September 2007

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