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Gastroenterology
Volume 132, Issue 3
, Pages 966-981
, March 2007
Identification of a Chemokine Network That Recruits FoxP3+ Regulatory T Cells Into Chronically Inflamed Intestine
References
- . Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol. 2004;22:891–928
- . The greater chemotactic network for lymphocyte trafficking: chemokines and beyond. Curr Opin Hematol. 2005;12:298–304
- . Chemokines in lymphocyte trafficking and intestinal immunity. Microcirculation. 2003;10:313–323
- . Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med. 2000;192:761–768
- . The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J Immunol. 2000;165:5069–5076
- . The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. J Exp Med. 2002;195:269–275
- . Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells. Nature. 2003;424:88–93
- . A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. J Immunol. 2000;165:2943–2949
- . Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem. 2000;275:22313–22323
- . CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest. 2003;111:1001–1010
- . A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol. 2003;170:3799–3805
- . CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol. 2003;170:1452–1461
- . Eotaxin (An essential mediator of eosinophil trafficking into mucosal tissues). Am J Respir Cell Mol Biol. 1999;21:291–295
- . Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10−/− mice and Rag-2−/− mice reconstituted with CD4+CD45RBhigh T cells. Eur J Immunol. 2001;31:1465–1474
- . Quantitation of chemokines (MDC, TARC) expression in mucosa from Crohn’s disease and ulcerative colitis. Eur Cytokine Netw. 2001;12:468–477
- . Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain. Gut. 1998;43:71–78
- . The SAMP1/Yit mouse: another step closer to modeling human inflammatory bowel disease. J Clin Invest. 2001;107:667–670
- . Mouse models for the study of Crohn’s disease. Trends Mol Med. 2003;9:218–222
- . Immune networks in animal models of inflammatory bowel disease. Inflamm Bowel Dis. 2003;9:246–259
- . Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease. J Clin Invest. 2001;107:695–702
- . The role of cryptopatch-derived intraepithelial lymphocytes in the development of chronic ileocecitis. Scand J Immunol. 2003;58:428–435
- . Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. Eur J Immunol. 2004;34:1561–1569
- . Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology. 2003;124:972–982
- . Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn’s disease. Gastroenterology. 2005;128:351–360
- . Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J Clin Invest. 2001;107:595–601
- . Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. J Exp Med. 1999;190:681–690
- . Rules of chemokine receptor association with T cell polarization in vivo. J Clin Invest. 2001;108:1331–1339
- . Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity. 1998;9:745–755
- . Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21:527–538
- . Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057–1061
- . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4:330–336
- . A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 1999;96:5698–5703
- . A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proc Natl Acad Sci U S A. 2000;97:5639–5644
- . Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J Pathol. 1996;178:201–206
- . Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn’s disease: a pivotal site of Th1-shifted immune response?. Lab Invest. 2005;85:137–145
- . In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1. Clin Exp Immunol. 2005;140:22–31
- . L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. J Immunol. 2005;174:2343–2352
- . Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998;187:129–134
- . CCR5 is characteristic of Th1 lymphocytes. Nature. 1998;391:344–345
- . Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med. 1998;187:875–883
- . Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J Leukoc Biol. 1999;65:691–699
- . The CC-chemokine receptor 5 (CCR5) is a marker of, but not essential for the development of human Th1 cells. Tissue Antigens. 1999;54:572–577
- . T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol. 1998;160:550–554
- . RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. J Exp Med. 1992;176:1489–1495
- . Recombinant guinea pig and human RANTES activate macrophages but not eosinophils in the guinea pig. J Immunol. 1997;159:1482–1489
- . C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells (Role for G proteins). J Immunol. 1994;153:4969–4977
- . RANTES: a versatile and controversial chemokine. Trends Immunol. 2001;22:83–87
- . Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system. Exp Hematol. 2006;34:1033–1040
- . Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol. 2003;170:3939–3943
- . Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo. J Immunol. 2004;172:3391–3398
- . Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest. 2004;114:1640–1649
- . Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells. J Immunol. 2006;177:840–851
Supported in part by grants from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (AI063064), the Eli and Edythe L. Broad Medical Foundation, the Sidney Kimmel Foundation, and the American Heart Association (to C.H.K.) and by research fellowships from Purdue Research Foundation (S.G.K.), ARP (H.W.L.), and Indiana University School of Medicine, Lafayette (R.J.P.).
PII: S0016-5085(07)00010-8
doi: 10.1053/j.gastro.2007.01.008
© 2007 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 132, Issue 3
, Pages 966-981
, March 2007

