« Previous
Next »
Gastroenterology
Volume 132, Issue 3
, Pages 955-965
, March 2007
CD40–CD40 Ligand Mediates the Recruitment of Leukocytes and Platelets in the Inflamed Murine Colon
References
- . Differential expression and regulation of murine CD40 in regional vascular beds. Am J Physiol Heart Circ Physiol. 2006;290:H631–H639
- . Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology. 2003;124:1249–1264
- . CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998;391:591–594
- . Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification. J Immunol. 2004;172:2011–2015
- . CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. Circulation. 2005;111:1690–1696
- . Plasma levels of soluble CD40 ligand are elevated in inflammatory bowel diseases. Int J Colorectal Dis. 2003;18:142–147
- . Association between enhanced soluble CD40 ligand and prothrombotic state in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2004;16:1147–1152
- . Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J Immunol. 1999;163:4049–4057
- . The role of CD40 in ulcerative colitis: histochemical analysis and clinical correlation. Eur J Gastroenterol Hepatol. 2002;14:237–241
- . Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice. Int Immunol. 1997;9:1111–1122
- . Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med. 1996;183:693–698
- . Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions. J Immunol. 2000;164:6005–6014
- . Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology. 2000;119:715–723
- . CD40L-positive platelets induce CD40L expression de novo in endothelial cells: adding a loop to microvascular inflammation. Arterioscler Thromb Vasc Biol. 2004;24:e162
- . Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40. Thromb Haemost. 1998;80:1008–1014
- . A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990;98:694–702
- . Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis. Dig Dis Sci. 2004;49:556–564
- . T cell-induced inflammation of the small and large intestine in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2006;290:G109–G119
- . Cytokine and adhesion molecule expression in SCID mice reconstituted with CD4+ T cells. Inflamm Bowel Dis. 2000;6:171–180
- . Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69:238–249
- . Quantitative measurement of gastrointestinal blood loss. II (Determination of 24-hour fecal blood loss by a chemical photospectrometric technique). J Lab Clin Med. 1959;53:777–788
- . Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol. 1998;114:385–391
- . Granulocyte turnover in the feline intestine. Inflammation. 1992;16:549–559
- . Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity (Assessment of inflammation in rat and hamster models). Gastroenterology. 1984;87:1344–1350
- . Time-dependent platelet-vessel wall interactions induced by intestinal ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2003;284:G1027–G1033
- . Quantitative analysis of small intestinal microcirculation in the mouse. Res Exp Med (Berl). 1998;198:23–35
- . Heterogeneity of expression of E- and P-selectins in vivo. Circ Res. 1996;79:560–569
- . Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. Biochem Biophys Res Commun. 1978;80:849–857
- . Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol. 1997;158:1825–1832
- . Inducible CD40 expression mediates NFkappaB activation and cytokine secretion in human colonic fibroblasts. Gut. 2003;52:1448–1456
- . CD40-mediated immune–nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration. Gastroenterology. 2004;126:63–80
- . The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40. Blood. 2001;98:1047–1054
- . Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1997;9:1213–1217
- . Pathogenesis of Crohn’s disease: multifocal gastrointestinal infarction. Lancet. 1989;2:1057–1062
- . CD40 ligand influences platelet release of reactive oxygen intermediates. Arterioscler Thromb Vasc Biol. 2005;25:2428–2434
- . Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med. 1999;190:1769–1782
- . The biology of P-selectin glycoprotein ligand-1: its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction. Thromb Haemost. 1999;81:1–7
- . A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion. Thromb Haemost. 2001;86:214–221
- . Modulation of the inflammatory response in cardiovascular disease. Hypertension. 2004;43:924–931
- . CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 1998;16:111–135
- . CD40-CD40 ligand. J Leukoc Biol. 2000;67:2–17
- . Inhibition of the CD40 pathway of monocyte activation by triazolopyrimidine. Clin Immunol. 1999;93:232–238
- . Thrombosis and inflammatory bowel disease. Clin Gastroenterol Hepatol. 2005;3:617–628
- . Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules. Am J Physiol Gastrointest Liver Physiol. 2005;288:G920–G926
- . Platelets circulate in an activated state in inflammatory bowel disease. Gastroenterology. 1994;106:840–845
- . Platelet dysfunction: a new dimension in inflammatory bowel disease. Gut. 1995;36:5–8
Supported by grants from the National Institute of Health (DK065649 to D.N.G.) and the Deutsche Forschungsgemeinschaft (VO998/1-1 to T.V.).
PII: S0016-5085(06)02677-1
doi: 10.1053/j.gastro.2006.12.027
© 2007 AGA Institute. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 132, Issue 3
, Pages 955-965
, March 2007

