This Month in Gastroenterology

(A) SERT mRNA expression in mucosal biopsies from sigmoid colon in healthy controls, diarrhea-predominant IBS, and patients. (B) p11 mRNA expression in mucosal biopsies from sigmoid colon in healthy controls and diarrhea-predominant IBS and constipation-predominant patients.

Percentage of patients in clinical and endoscopic remission at week 8 (intent-to-treat population, n = 341). ^**P < .01; ^***P < .001. QD, once daily.

ATB-337, diclofenac linked to a hydrogen-sulfide releasing molecule, does not induce the formation of hemorrhagic erosions in the stomach (upper panel) despite profoundly suppressing gastric prostaglandin synthesis (lower panel). Co-administration of ADT-OH, the separated hydrogen sulfide-releasing moiety of ATB-337 and diclofenac, did not affect the severity of gastric damage produced as compared with diclofenac alone. Equimolar doses (27 μmol/kg) of diclofenac, ATB-337, and ADT-OH were administered orally, and the stomach examined 3 hours later. Each bar represents the mean ± SEM, and each group consisted of 5–6 rats. *P < .05 versus the vehicle-treated group.

Survival rates of normothermic (NT) and mild hypothermic (mild HT) mice (n = 9–10 per group) in the first 24 hours after acetaminophen (APAP) challenge. Log-rank test was used for statistical analysis.