Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial

Colombel, Jean–Frédéric; Sandborn, William J.; Rutgeerts, Paul; Enns, Robert; Hanauer, Stephen B.; Panaccione, Remo; Schreiber, Stefan; Byczkowski, Dan; Li, Ju; Kent, Jeffrey D.; Pollack, Paul F.

doi:10.1053/j.gastro.2006.11.041

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Volume 132, Issue 1 , Pages 52-65, January 2007

Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial

Jean–Frédéric Colombel
- Department of Hepatogastroenterology, Hôpital Claude Huriez, Centre Hospitalier Universitaire de Lille, Lille, France
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
- Address requests for reprints to: Jean-Frédéric Colombel, MD, Hôpital Claude Huriez, Centre Hospitalier Universitaire de Lille, Rue Michel Polonovski, Lille, France 59037. fax: (33) 3-20-44-47-13.
William J. Sandborn
- Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
Paul Rutgeerts
- Department of Gastro-Enterologie, University Hospital of Gasthuisberg, Leuven, Belgium
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
Robert Enns
- Department of Medicine, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
Stephen B. Hanauer
- Section of Gastroenterology, University of Chicago, Chicago, Illinois
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
Remo Panaccione
- Department of Medicine, Inflammatory Bowel Disease Clinic, University of Calgary, Calgary, Alberta, Canada
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
Stefan Schreiber
- Department of General Internal Medicine and Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany
- Jean-Frédéric Colombel, William Sandborn, Paul Rutgeerts, Robert Enns, Stephen Hanauer, Remo Panaccione, and Stefen Schreiber have served as consultants for Abbott Laboratories and have participated in continuing medical education events supported by unrestricted educational grants from Abbott Laboratories.
Dan Byczkowski
- Department of Immunology Development, Abbott Laboratories, Parsippany, New Jersey
- Dan Byczkowski, Ju Li, Jeffrey Kent, and Paul Pollack are employees of Abbott Laboratories.
Ju Li
- Department of Biostatistics and Data Management, Abbott Laboratories, Abbott Park, Illinois
- Dan Byczkowski, Ju Li, Jeffrey Kent, and Paul Pollack are employees of Abbott Laboratories.
Jeffrey D. Kent
- Department of Immunology Development, Abbott Laboratories, Parsippany, New Jersey
- Dan Byczkowski, Ju Li, Jeffrey Kent, and Paul Pollack are employees of Abbott Laboratories.
Paul F. Pollack
- Department of Immunology Development, Abbott Laboratories, Parsippany, New Jersey
- Dan Byczkowski, Ju Li, Jeffrey Kent, and Paul Pollack are employees of Abbott Laboratories.

Received 11 August 2006; accepted 28 September 2006. published online 06 December 2006.

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Supported by a research grant from Abbott Laboratories (Abbott Park, IL).A list of the CHARM study investigators and sites appears in Appendix 1.

PII: S0016-5085(06)02522-4

doi:10.1053/j.gastro.2006.11.041

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