Gastroenterology
Volume 132, Issue 1 , Pages 103-112 , January 2007

Impact of Reducing Peginterferon Alfa-2a and Ribavirin Dose During Retreatment in Patients With Chronic Hepatitis C

  • Mitchell L. Shiffman

      Affiliations

    • Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia
    • Corresponding Author InformationAddress requests for reprints to: Mitchell L Shiffman, MD, Hepatology Section, Virginia Commonwealth University Medical Center, Box 980341, Richmond, Virginia 23298. fax: (804) 828-4945, and HALT-C Trial Data Coordinating Center, New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472.
    • ,
  • Marc G. Ghany

      Affiliations

    • Liver Diseases Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    • ,
  • Timothy R. Morgan

      Affiliations

    • Division of Gastroenterology, University of California-Irvine, Irvine, California, and Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, California
    • ,
  • Elizabeth C. Wright

      Affiliations

    • New England Research Institutes, Watertown, Massachusetts
    • ,
  • Gregory T. Everson

      Affiliations

    • Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, Colorado
    • ,
  • Karen L. Lindsay

      Affiliations

    • Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California
    • ,
  • Anna S.F. Lok

      Affiliations

    • Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan
    • ,
  • Herbert L. Bonkovsky

      Affiliations

    • Departments of Medicine and Molecular & Structural Biology and The Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, Connecticut
    • ,
  • Adrian M. Di Bisceglie

      Affiliations

    • Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri
    • ,
  • William M. Lee

      Affiliations

    • Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas
    • ,
  • Jules L. Dienstag

      Affiliations

    • Gastrointestinal Unit, Medical Services, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • David R. Gretch

      Affiliations

    • Department of Laboratory Medicine, University of Washington, Seattle, Washington
    • ,
  • HALT-C Trial Group

Received 10 April 2006 ,Accepted 12 October 2006.

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 This is publication number 20 from the HALT-C Trial Group.Supported by the National Institute of Diabetes & Digestive & Kidney Diseases (contract numbers are listed in Appendix); by the National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute, the National Center for Minority Health and Health Disparities, and General Clinical Research Center grants from the National Center for Research Resources, National Institutes of Health (grant numbers are listed in Appendix); and by Hoffmann-La Roche, Inc., through a Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health.Financial relationships of the authors with Hoffmann-La Roche, Inc., are as follows: M. L. Shiffman is a consultant, on the speaker’s bureau, and receives research support; T. R. Morgan is on the speaker’s bureau and receives research support; G. T. Everson is a consultant, on the speaker’s bureau, and receives research support; K. L. Lindsay is a consultant and receives research support; A. S. F. Lok is a consultant and receives research support; H. L. Bonkovsky is on the speaker’s bureau and receives research support; A. M. Di Bisceglie is a consultant and receives research support; and W. M. Lee receives research support. Authors with no financial relationships related to this project are M. G. Ghany, E. C. Wright, J. L. Dienstag, and D. R. Gretch.M.L.S., M.G.G, T.R.M, and E.C.W contributed equally to the analysis of data and writing of this manuscript.

PII: S0016-5085(06)02466-8

doi: 10.1053/j.gastro.2006.11.011

Gastroenterology
Volume 132, Issue 1 , Pages 103-112 , January 2007

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