Gastroenterology
Volume 132, Issue 1 , Pages 127-138, January 2007

The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer

  • Ajay Goel

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine and the Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas
    • Corresponding Author InformationAddress requests for reprints to: Ajay Goel, PhD, Baylor University Medical Center, 3500 Gaston Avenue, Gastrointestinal Cancer Research Laboratory, Suite H-250, Dallas, Texas 75246. fax: (214) 818-9292
    • ,
  • Takeshi Nagasaka

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine and the Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas
    • ,
  • Christian N. Arnold

      Affiliations

    • University of Freiburg, Department of Internal Medicine, Division of Gastroenterology, Freiburg, Germany
    • ,
  • Toru Inoue

      Affiliations

    • Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • ,
  • Cody Hamilton

      Affiliations

    • Institute for Health Care Research and Improvement, Baylor University Medical Center, Dallas, Texas
    • ,
  • Donna Niedzwiecki

      Affiliations

    • CALGB Statistical Center, Duke University Medical Center, Durham, North Carolina
    • ,
  • Carolyn Compton

      Affiliations

    • Department of Pathology, McGill University, Montreal, Canada
    • ,
  • Robert J. Mayer

      Affiliations

    • Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Richard Goldberg

      Affiliations

    • University of North Carolina-Chapel Hill, Chapel Hill, North Carolina
    • Corresponding Author InformationC. Richard Boland, MD, Baylor University Medical Center, 3500 Gaston Avenue, Gastrointestinal Cancer Research Laboratory, Suite H-250, Dallas, Texas 75246. fax: (214) 818-9292.
    • ,
  • Monica M. Bertagnolli

      Affiliations

    • Brigham and Women’s Hospital, Boston, Massachusetts
    • ,
  • C. Richard Boland

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine and the Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas

Received 25 May 2006; accepted 31 August 2006. published online 26 September 2006.

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 Supported by a grant from the NIH (RO1-CA 72851; to C.R.B.), an American Cancer Society-IRG award (to A.G), and a grant from Dr. Mildred-Scheel-Stiftung, Germany (to C.N.A.); and research for CALGB 9865 was supported, in part, by grants from the National Cancer Institute (CA31946) to the Cancer and Leukemia Group B (Richard L. Schilsky, Chairman).The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.Please see Appendix for participating institutes.

PII: S0016-5085(06)02078-6

doi:10.1053/j.gastro.2006.09.018

Gastroenterology
Volume 132, Issue 1 , Pages 127-138, January 2007

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