Gastroenterology
Volume 130, Issue 3 , Pages 639-649 , March 2006

Obesity: A Challenge to Esophagogastric Junction Integrity

  • John E. Pandolfino

      Affiliations

    • Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois
    • Corresponding Author InformationAddress reprint requests to: John E. Pandolfino, MD, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Department of Medicine, 676 N. St. Clair Street, Suite 1400, Chicago, Illinois 60611. fax: (312) 695-3999.
    • ,
  • Hashem B. El–Serag

      Affiliations

    • Department of Medicine, Baylor College of Medicine, Houston VA Medical Center, Houston, Texas
    • ,
  • Qing Zhang

      Affiliations

    • Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois
    • ,
  • Nimeesh Shah

      Affiliations

    • Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois
    • ,
  • Sudip K. Ghosh

      Affiliations

    • Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois
    • ,
  • Peter J. Kahrilas

      Affiliations

    • Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois

Received 2 August 2005 ,Accepted 30 November 2005.

References 

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  16. Kahrilas PJ . The role of hiatus hernia in GERD . Yale J Biol Med . 1999;72:101–111
  17. Sloan S , Rademaker AW , Kahrilas PJ . Determinants of gastroesophageal junction incompetence (hiatal hernia, lower esophageal sphincter, or both?) . Ann Intern Med . 1992;117:977–982
  18. Kahrilas PJ , Shi G , Manka M , Joehl RJ . Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia . Gastroenterology . 2000;118:688–695
  19. Mittal RK , Lange RC , McCallum RW . Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia . Gastroenterology . 1987;92:130–135
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  21. Mittal RK , Rochester DF , McCallum RW . Effect of the diaphragmatic contraction on lower oesophageal sphincter pressure in man . Gut . 1987;28:1564–1568
  22. Kahrilas PJ , Lin S , Chen J , Manka M . The effect of hiatus hernia on gastro-oesophageal junction pressure . Gut . 1999;44:476–482
  23. Weinsier RL , Hunter GR , Gower BA , Schutz Y , Darnell BE , Zuckerman PA . Body fat distribution in white and black women (different patterns of intraabdominal and subcutaneous abdominal adipose tissue utilization with weight loss) . Am J Clin Nutr . 2001;74:631–636

 Supported by RO1 DC00646 (PJK) and K23 DK062170-01 (JEP) from the Public Health Service.Contributed devices from Sierra Scienti .c,Inc.

PII: S0016-5085(05)02526-6

doi: 10.1053/j.gastro.2005.12.016

Gastroenterology
Volume 130, Issue 3 , Pages 639-649 , March 2006

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