Gastroenterology
Volume 129, Issue 3 , Pages 1121-1124 , September 2005

CIMP, at Last

  • Jean-Pierre J. Issa

      Affiliations

    • University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • Corresponding Author InformationAddress requests for reprints to: Jean-Pierre Issa, MD, Department of Leukemia, M. D. Anderson Cancer Center, Unit 428, 1515 Holcombe, Houston, Texas 77030; fax: (713) 794-4297.
    • ,
  • Lanlan Shen

      Affiliations

    • Sapporo Medical University, Sapporo, Japan
    • ,
  • Minoru Toyota

      Affiliations

    • Sapporo Medical University, Sapporo, Japan

References 

  1. Vogelstein B , Kinzler KW . Cancer genes and the pathways they control . Nat Med . 2004;10:789–799
  2. Baylin SB , Herman JG , Graff JR , Vertino PM , Issa JPJ . Alterations in DNA methylation–A fundamental aspect of neoplasia . Adv Cancer Res . 1998;72:141–196
  3. Jones PA , Baylin SB . The fundamental role of epigenetic events in cancer . Nat Rev Genet . 2002;3:415–428
  4. Sakai T , Toguchida J , Ohtani N , Yandell DW , Rapaport JM , Dryja TP . Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene . Am J Hum Genet . 1991;48:880–888
  5. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma . Proc Natl Acad Sci U S A . 1994;91:9700–9704
  6. Herman JG , Baylin SB . Gene silencing in cancer in association with promoter hypermethylation . N Engl J Med . 2003;349:2042–2054
  7. Bestor TH . Unanswered questions about the role of promoter methylation in carcinogenesis . Ann N Y Acad Sci . 2003;983:22–27
  8. Loeb LA . A mutator phenotype in cancer . Cancer Res . 2001;61:3230–3239
  9. Kinzler KW , Vogelstein B . Lessons form hereditary colorectal cancer . Cell . 1996;87:159–170
  10. Toyota M , Ahuja N , Ohe-Toyota M , Herman JG , Baylin SB , Issa JPJ . CpG island methylator phenotype in colorectal cancer . Proc Natl Acad Sci U S A . 1999;96:8681–8686
  11. Issa JP . CpG island methylator phenotype in cancer . Nat Rev Cancer . 2004;4:988–993
  12. Samowitz WS, Albertsen H, Herrick J, Levin TR, Sweeney C, Murtaugh MA, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer . Gastroenterology . 2005;129:837–845
  13. Shen L, Ahuja N, Shen Y, Habib NA, Toyota M, Rashid A, et al. DNA methylation and environmental exposures in human hepatocellular carcinoma . J Natl Cancer Inst . 2002;94:755–761
  14. Garcia-Manero G, Daniel J, Smith TL, Kornblau SM, Lee MS, Kantarjian HM, et al. DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia . Clin Cancer Res . 2002;8:2217–2224
  15. Toyota M , Kopecky KJ , Toyota MO , Jair KW , Willman CL , Issa JP . Methylation profiling in acute myeloid leukemia . Blood . 2001;97:2823–2829
  16. Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JP, Hruban RH, et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma . Cancer Res . 2000;60:1835–1839
  17. Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype . Cancer Res . 1999;59:5438–5442
  18. Strathdee G, Appleton K, Illand M, Millan DW, Sargent J, Paul J, et al. Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes . Am J Pathol . 2001;158:1121–1127
  19. Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, et al. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas . Cancer Res . 2005;65:828–834
  20. Whitehall VL, Wynter CV, Walsh MD, Simms LA, Purdie D, Pandeya N, et al. Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer . Cancer Res . 2002;62:6011–6014
  21. van Rijnsoever M , Grieu F , Elsaleh H , Joseph D , Iacopetta B . Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands . Gut . 2002;51:797–802
  22. Eads CA, Lord RV, Wickramasinghe K, Long TI, Kurumboor SK, Bernstein L, et al. Epigenetic patterns in the progression of esophageal adenocarcinoma . Cancer Res . 2001;61:3410–3418
  23. Esteller M, Tortola S, Toyota M, Capella G, Peinado MA, Baylin SB, et al. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status . Cancer Res . 2000;60:129–133
  24. Yamashita K , Dai T , Dai Y , Yamamoto F , Perucho M . Genetics supersedes epigenetics in colon cancer phenotype . Cancer Cell . 2003;4:121–131
  25. Yu J, Zhang H, Gu J, Lin S, Li J, Lu W, et al. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma . BMC Cancer . 2004;4:65
  26. Toyota M , Ohe-Toyota M , Ahuja N , Issa JP . Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype . Proc Natl Acad Sci U S A . 2000;97:710–715
  27. Jass JR . Pathogenesis of colorectal cancer . Surg Clin North Am . 2002;82:891–904
  28. van Rijnsoever M , Elsaleh H , Joseph D , McCaul K , Iacopetta B . CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer . Clin Cancer Res . 2003;9:2898–2903
  29. Shen L , Kondo Y , Hamilton SR , Rashid A , Issa JP . p14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53 . Gastroenterology . 2003;124:626–633
  30. Chirieac LR , Shen L , Catalano PJ , Issa JP , Hamilton SR . Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation . Am J Surg Pathol . 2005;29:429–436
  31. Jass JR . HNPCC and sporadic MSI-H colorectal cancer (a review of the morphological similarities and differences) . Fam Cancer . 2004;3:93–100
  32. Frazier ML, Xi L, Zong J, Viscofsky N, Rashid A, Wu EF, et al. Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer . Cancer Res . 2003;63:4805–4808
  33. Young J, Barker MA, Simms LA, Walsh MD, Biden KG, Buchanan D, et al. Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer . Clin Gastroenterol Hepatol . 2005;3:254–263
  34. Issa JP , Ahuja N , Toyota M , Bronner MP , Brentnall TA . Accelerated age-related CpG island methylation in ulcerative colitis . Cancer Res . 2001;61:3573–3577
  35. Sato F, Harpaz N, Shibata D, Xu Y, Yin J, Mori Y, et al. Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis . Cancer Res . 2002;62:1148–1151
  36. Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma . Am J Pathol . 2002;160:787–794
  37. Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng Z, Fukuyama Y, et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer . Int J Cancer . 2003;103:153–160
  38. Egger G , Liang G , Aparicio A , Jones PA . Epigenetics in human disease and prospects for epigenetic therapy . Nature . 2004;429:457–463

PII: S0016-5085(05)01548-9

doi: 10.1053/j.gastro.2005.07.040

Gastroenterology
Volume 129, Issue 3 , Pages 1121-1124 , September 2005

Article Tools