Gastroenterology
Volume 129, Issue 3 , Pages 837-845 , September 2005

Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer

  • Wade S. Samowitz

      Affiliations

    • Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah
    • Corresponding Author InformationAddress requests for reprints to: Wade S. Samowitz, MD, Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132. fax: (801) 585-3831.
    • ,
  • Hans Albertsen

      Affiliations

    • Health Research Center, Department of Family and Preventive Medicine, Salt Lake City, Utah
    • ,
  • Jennifer Herrick

      Affiliations

    • Health Research Center, Department of Family and Preventive Medicine, Salt Lake City, Utah
    • ,
  • Theodore R. Levin

      Affiliations

    • Kaiser Permanente Medical Center, Walnut Creek, California
    • ,
  • Carol Sweeney

      Affiliations

    • Health Research Center, Department of Family and Preventive Medicine, Salt Lake City, Utah
    • ,
  • Maureen A. Murtaugh

      Affiliations

    • Health Research Center, Department of Family and Preventive Medicine, Salt Lake City, Utah
    • ,
  • Roger K. Wolff

      Affiliations

    • Health Research Center, Department of Family and Preventive Medicine, Salt Lake City, Utah
    • ,
  • Martha L. Slattery

      Affiliations

    • Health Research Center, Department of Family and Preventive Medicine, Salt Lake City, Utah

Received 21 January 2005 ,Accepted 26 May 2005.

References 

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  2. Toyota M , Ohe-Toyota M , Ahuja N , Issa JP . Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype . Proc Natl Acad Sci U S A . 2000;97:710–715
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  7. Samowitz WS , Curtin K , Ma KN , et al.   Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level . Cancer Epidemiol Biomarkers Prev . 2001;10:917–923
  8. Samowitz WS , Holden JA , Curtin K , et al.   Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer . Am J Pathol . 2001;158:1517–1524
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  13. Samowitz WS , Curtin K , Schaffer D , Robertson M , Leppert M , Slattery ML . Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival (a population-based study) . Cancer Epidemiol Biomarkers Prev . 2000;9:1193–1197
  14. Samowitz WS , Curtin K , Ma KN , et al.   Prognostic significance of p53 mutations in colon cancer at the population level . Int J Cancer . 2002;99:597–602
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  18. Hoang J-M , Cottu PH , Thuille B , Salmon RJ , Thomas G , Hamelin R . BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines . Cancer Res . 1997;57:300–303
  19. Rajagopalan H , Bardelli A , Lengauer C , Kinzler KW , Vogelstein B , Velculescu VE . Tumorigenesis (RAF/RAS oncogenes and mismatch-repair status) . Nature . 2002;418:934
  20. Oliveira C , Westra JL , Arango D , et al.   Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status . Hum Mol Genet . 2004;13:2303–2311
  21. Deng G , Bell I , Crawley S , et al.   BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer . Clin Cancer Res . 2004;10:191–195
  22. Samowitz WS , Curtin K , Lin HH , et al.   The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer . Gastroenterology . 2001;121:830–838
  23. Domingo E , Laiho P , Ollikainen M , et al.   BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing . J Med Genet . 2004;41:664–668
  24. Rashid A , Issa JP . CpG island methylation in gastroenterologic neoplasia (a maturing field) . Gastroenterology . 2004;127:1578–1588

 The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official view of the National Cancer Institute.Supported by grants CA48998 and CA61757 (to M.L.S.), and by the Utah Cancer Registry, which is funded by contract N01-PC-67000 from the National Cancer Institute, with additional support from the State of Utah Department of Health, the University of Utah, the Northern California Cancer Registry, and the Sacramento Tumor Registry.

PII: S0016-5085(05)01122-4

doi: 10.1053/j.gastro.2005.06.020

Gastroenterology
Volume 129, Issue 3 , Pages 837-845 , September 2005

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