Gastroenterology
Volume 128, Issue 7 , Pages 1796-1804, June 2005

Human Colorectal Cancer Cells Induce T-Cell Death Through Release of Proapoptotic Microvesicles: Role in Immune Escape

  • Veronica Huber

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Stefano Fais

      Affiliations

    • Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy
    • ,
  • Manuela Iero

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Luana Lugini

      Affiliations

    • Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy
    • ,
  • Paola Canese

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Paola Squarcina

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Annamaria Zaccheddu

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Marisa Colone

      Affiliations

    • Department of Health and Technology, Istituto Superiore di Sanità, Rome, Italy
    • ,
  • Giuseppe Arancia

      Affiliations

    • Department of Health and Technology, Istituto Superiore di Sanità, Rome, Italy
    • ,
  • Massimo Gentile

      Affiliations

    • Department of Experimental Medicine and Pathology, Virology Section, University “La Sapienza,” Rome, Italy
    • ,
  • Ettore Seregni

      Affiliations

    • Unit of Nuclear Medicine, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Roberta Valenti

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Giuseppina Ballabio

      Affiliations

    • Unit of Nuclear Medicine, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Filiberto Belli

      Affiliations

    • Unit of Colorectal Surgery, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Ermanno Leo

      Affiliations

    • Unit of Colorectal Surgery, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Giorgio Parmiani

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Licia Rivoltini

      Affiliations

    • Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    • Corresponding Author InformationAddress requests for reprints to: Licia Rivoltini, MD, Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy. fax: (39) 02-2390-2630.

Received 25 August 2004; accepted 9 March 2005.

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 Supported by grants from the Italian Association for Cancer Research (Milan) and Fondo pergli Investimenti della Ricerca di Base, Ministero dell’Instruzione, dell’Università e della Ricerca (FIRB-MIUR) RBNE017B4C (Rome).

PII: S0016-5085(05)00568-8

doi:10.1053/j.gastro.2005.03.045

Gastroenterology
Volume 128, Issue 7 , Pages 1796-1804, June 2005

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