Gastroenterology
Volume 128, Issue 4, Supplement 1 , Pages S109-S120 , April 2005

Consequences of testing for celiac disease

  • Ann Cranney

      Affiliations

    • Ottawa Health Research Institute, Ottawa, Canada
    • Corresponding Author InformationAddress requests for reprints to: Ann Cranney, MD, FRCPC, C402, Clinical Epidemiology Program, Ottawa Hospital Civic Campus, 1053 Carling Ave, Ottawa, Ontario, K1Y 4E9. fax: (613) 761-5492
  • ,
  • Alaa Rostom

      Affiliations

    • Gastrointestinal Clinical Research Unit, Ottawa Hospital, Ottawa, Canada
  • ,
  • Richmond Sy

      Affiliations

    • Gastrointestinal Clinical Research Unit, Ottawa Hospital, Ottawa, Canada
  • ,
  • Catherine Dubé

      Affiliations

    • Gastrointestinal Clinical Research Unit, Ottawa Hospital, Ottawa, Canada
  • ,
  • Navaz Saloogee

      Affiliations

    • Gastrointestinal Clinical Research Unit, Ottawa Hospital, Ottawa, Canada
  • ,
  • Chantal Garritty

      Affiliations

    • Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
  • ,
  • David Moher

      Affiliations

    • Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    • University of Ottawa, Ottawa, Ontario, Canada
  • ,
  • Margaret Sampson

      Affiliations

    • Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
  • ,
  • Li Zhang

      Affiliations

    • University of Saskatchewan, Saskatoon, Saskatchewan, Canada
  • ,
  • Fatemeh Yazdi

      Affiliations

    • Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
  • ,
  • Vasil Mamaladze

      Affiliations

    • Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
  • ,
  • Irene Pan

      Affiliations

    • University of Ottawa, Ottawa, Ontario, Canada
  • ,
  • Joanne MacNeil

      Affiliations

    • Gastrointestinal Clinical Research Unit, Ottawa Hospital, Ottawa, Canada

References 

  1. Tommasini A , Not T , Kiren V , et al.   Mass screening for celiac diseaes using antihuman transglutaminase antibody assay . Arch Dis Child . 2004;89:15
  2. Wells GA , Shea B , O’Connell D , Peterson J , Welch V , Tugwell P . The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Symposium on Systematic Reviews: Beyond the Basics . 2000; July 2000. Oxford, England
  3. Egger M , Schneider M , Smith GD . Meta-analysis spurious precision? Meta-analysis of observational studies . BMJ . 1998;316:140–144
  4. Kemppainen TA , Kosma VM , Janatuinen EK , Julkunen RJ , Pikkarainen PH , Uusitupa MI . Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet—association with the grade of mucosal villous atrophy . Am J Clin Nutr . 1998;67:482–487
  5. Amin R , Murphy N , Edge J , Ahmed ML , Acerini CL , Dunger DB . A longitudinal study of the effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease . Diabetes Care . 2002;25:1117–1122
  6. Bardella MT , Fredella C , Prampolini L , Molteni N , Giunta AM , Bianchi PA . Body composition and dietary intakes in adult celiac disease patients consuming a strict gluten-free diet . Am J Clin Nutr . 2000;72:937–939
  7. Barera G, Mora S, Brambilla P, Ricotti A, Menni L, Beccio S, et al. Body composition in children with celiac disease and the effects of a gluten-free diet (a prospective case-control study) . Am J Clin Nutr . 2000;72:71–75
  8. Boersma B , Houwen RHJ , Blum WF , vanDoorn J , Wit JM . Catch-up growth and endocrine changes in childhood celiac disease . Horm Res . 2002;58:57–65
  9. Rea F, Polito C, Marotta A, Di Toro A, Iovene A, Collini R, et al. Restoration of body composition in celiac children after one year of gluten-free diet . J Pediatr Gastroenterol Nutr . 1996;23:408–412
  10. Sategna-Guidetti C, Grosso SB, Grosso S, Mengozzi G, Aimo G, Zaccaria T, et al. The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients . Aliment Pharmacol Ther . 2000;14:35–43
  11. Sategna-Guidetti C, Volta U, Ciacci C, Usai P, Carlino A, De Franceschi L, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal (an Italian multicenter study) . Am J Gastroenterol . 2001;96:751–757
  12. Valdimarsson T , Toss G , Lofman O , Strom M . Three years’ follow-up of bone density in adult coeliac disease (significance of secondary hyperparathyroidism) . Scand J Gastroenterol . 2000;35:274–280
  13. Valdimarsson T , Lofman O , Toss G , Strom M . Reversal of osteopenia with diet in adult coeliac disease . Gut . 1996;38:322–327
  14. Westman E , Ambler GR , Royle M , Peat J , Chan A . Children with coeliac disease and insulin dependent diabetes mellitus—growth, diabetes control and dietary intake . J Pediatr Endocrinol Metab . 1999;12:433–442
  15. Annibale B , Severi C , Chistolini A , et al.   Efficacy of gluten free diet alone on recovery from iron deficiency anemia in adult celiac patients . Am J Gastroenterol . 2001;96:132–137
  16. Arato A , Korner A , Veres G , Dezsofi A , Ujpal I , Madacsy L . Frequency of coeliac disease in Hungarian children with type 1 diabetes mellitus . Eur J Pediatr . 2002;162:1–5
  17. Atkinson K , Tokmakajian S , Watson W , Gregor J . Evaluation of the endomysial antibody for celiac disease (operating properties and associated cost implications in clinical practice) . Can J Gastroenterol . 1997;11:673–677
  18. Bardella MT , Molteni N , Quatrini M , Velio P , Ranzi T , Bianchi PA . Clinical, biochemical and histological abnormalities in adult celiac patients on gluten-free diet . Gastroenterol Clin Biol . 1985;9:787–789
  19. Corrao G, Corazza GR, Bagnardi V, Brusco G, Ciacci C, Cottone M, et al. Mortality in patients with coeliac disease and their relatives (a cohort study) . Lancet . 2001;358:356–361
  20. Fabiani E, Catassi C, Villari A, Gismondi P, Pierdomenico R, Ratsch IM, et al. Dietary compliance in screening-detected coeliac disease adolescents . Acta Paediatr . 1996;412:65–67
  21. Fabiani E , Taccari LM , Ratsch IM , Di Giuseppe S , Coppa GV , Catassi C . Compliance with gluten-free diet in adolescents with screening-detected celiac disease (a 5-year follow-up study) . J Pediatr . 2000;136:841–843
  22. Greco L , Mayer M , Ciccarelli G , Troncone R , Auricchio S . Compliance to a gluten-free diet in adolescents, or “what do 300 coeliac adolescents eat every day?” . Ital J Gastroenterol Hepatol . 1997;29:305–310
  23. Harewood GC , Murray JA . Diagnostic approach to a patient with suspected celiac disease (a cost analysis) . Dig Dis Sci . 2001;46:2510–2514
  24. Holmes GK , Stokes PL , Sorahan TM , Prior P , Waterhouse JA , Cooke WT . Coeliac disease, gluten-free diet, and malignancy . Gut . 1976;17:612–619
  25. Johnston SD , Watson RGP , McMillan SA , Sloan J , Love AHG . Celiac disease detected by screening is not silent—simply unrecognized . Q J Med . 1998;91:853–860
  26. Poddar U , Thapa BR , Nain CK , Prasad A , Singh K . Celiac disease in India (are they true cases of celiac disease?) . J Pediatr Gastroenterol Nutr . 2002;35:508–512
  27. Saukkonen T , Vaisanen S , Akerblom HK , Savilahti E . Coeliac disease in children and adolescents with type 1 diabetes (a study of growth, glycemic control, and experiences of families) . Acta Pediatrica . 2002;91:297–302
  28. Smecuol E, Gonzalez D, Mautalen C, Siccardi A, Cataldi M, Niveloni S, et al. Longitudinal study on the effect of treatment on body composition and anthropometry of celiac disease patients . Am J Gastroenterol . 1997;92:639–643
  29. Thomason K , West J , Logan RFA , Coupland C , Holmes GKT . Fracture experience of patients with coeliac disease (a population based survey) . Gut . 2003;52:518–522
  30. Addolorato G, Capristo E, Ghittoni G, Valeri C, Masciana R, Ancona C, et al. Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet (a longitudinal study) . Scand J Gastroenterol . 2001;36:502–506
  31. Bai JC, Gonzalez D, Mautalen C, Mazure R, Pedreira S, Vazquez H, et al. Long-term effect of gluten restriction on bone mineral density of patients with coeliac disease . Aliment Pharmacol Ther . 1997;11:157–164
  32. Kemppainen T, Kroger H, Janatuinen E, Arnala I, Lamberg-Allardt C, Karkkainen M, et al. Bone recovery after a gluten-free diet (a 5-year follow-up study) . Bone . 1999;25:355–360
  33. Mora S, Barera G, Beccio S, Menni L, Proverbio MC, Bianchi C, et al. A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease . J Pediatr . 2001;139:516–521
  34. Mustalahti K , Collin P , Sievanen H , Salmi J , Maki M . Osteopenia in patients with clinically silent coeliac disease warrants screening . Lancet . 1999;354:744–745
  35. Zaccari G , Mazzetti DP , Paone FM , Guidiceandrea P . A proposal for coeliac disease screening of all infants at the age of fifteen months . Gastroenterol Int . 1996;9:11–15
  36. Ciacci C , Cirillo M , Auriemma G , Di Dato G , Sabbatini F , Mazzacca G . Celiac disease and pregnancy outcome . Am J Gastroenterol . 1996;91:718–722
  37. Norgard B , Fonager K , Sorensen HT , Olsen J . Birth outcomes of women with celiac disease (a nationwide historical cohort study) . Am J Gastroenterol . 1999;94:2435–2440
  38. Hogberg L , Grodzinsky E , Stenhammar L . Better dietary compliance in patients with celiac disease diagnosed in early childhood . Scand J Gastenterol . 2003;38:751–754
  39. Mariani P, Viti MG, Montuori M, LaVecchia A, Cipolletta E, Calvani I, et al. The gluten-free diet (a nutritional risk factor for adolescents with celiac disease?) . J Pediatr Gastroentrol Nutr . 1998;27:519–523
  40. Bernstein CN , Leslie WD , LeBoff MS . AGA technical review on osteoporosis in gastrointestinal diseases . Gastroenterology . 2003;124:795–841
  41. Gomez JC, Selvaggio G, Pizarro B, Viola MJ, La Motta G, Smecuol E, et al. Value of a screening algorithm for celiac disease using tissue transglutaminase antibodies as first level in a population-based study . Am J Gastroenterol . 2002;97:2785–2790
  42. West J , Logan RFA , Card TR , Smith C , Hubbard R . Fracture risk in people with celiac disease (a population-based cohort study) . Gastroenterology . 2003;125:429–436
  43. Peters U , Askling J , Gridley G , Ekbom A , Linet M . Causes of death in patients with celiac disease in a population-based Swedish cohort . Arch Intern Med . 2003;163:1566–1572
  44. Logan RF , Rifkind EA , Turner ID , Ferguson A . Mortality in celiac disease . Gastroenterology . 1989;97:265–271
  45. Cottone M , Termini A , Oliva L , et al.   Mortality and causes of death in celiac disease in a Mediterranean area . Dig Dis Sci . 1999;44:2538–2541
  46. Kemppainen T, Kroger H, Janatuinen E, Arnala I, Kosma VM, Pikkarainen P, et al. Osteoporosis in adult patients with celiac disease . Bone . 1999;24:249–255
  47. McFarlane XA , Bhalla AK , Reeves DE , Morgan LM , Robertson DA . Osteoporosis in treated adult coeliac disease . Gut . 1995;36:710–714
  48. Vasquez H, Mazure R, Gonzalez D, Flores D, Pedreira S, Niveloni S, et al. Risk of fractures in celiac disease patients (a cross-sectional, case-control study) . Am J Gastroenterol . 2000;95:183–189
  49. Fickling WE , McFarlane XA , Bhalla AK , Robertson DAF . The clinical impact of metabolic bone disease in celiac disease . Postgrad Med J . 2001;77:33–36
  50. Moreno ML , Vazquez H , Mazure R , et al.   Stratification of bone fracture risk in patients with celiac disease . Clin Gastroenterol Hepatol . 2004;2:127–134
  51. Ciacci C , Maurelli L , Klain M , et al.   Effects of dietary treatment on bone mineral density in adults with celiac disease (factors predicting response) . Am J Gastroenterol . 1997;92:96
  52. Mora S , Barera G , Beccio S , et al.   Bone density and bone metabolism are normal after long-term gluten-free diet in young celiac patients . Am J Gastroenterol . 1999;94:398–403
  53. Ciacci C , Cirillo M , Cavallaro R , Mazzacca G . Long-term follow-up of celiac adults on gluten-free diet (prevalence and correlates of intestinal damage) . Digestion . 2002;66:178–185
  54. Vestergaard P , Mosekilde L . Fracture risk in patients with celiac disease, Crohn’s disease, and ulcerative colitis (a nationwide follow-up study of 16,416 patients in Denmark) . Am J Epidemiol . 2002;156:10
  55. Dubé C, Rostom A, Sy R, Cranney A, Saloojee N, Garritty C, et al. The prevalence of celiac disease in average risk and at-risk western European populations (a systematic review) . Gastroenterology . 2005;128:S57–S67
  56. CCOHTA Guidelines for economic evaluation of pharmaceuticals. Canada . 2nd edition. Ottawa: CCOHTA; 1997;

 Supported by a grant from the Agency for Healthcare Research and Quality (to University of Ottawa EPC Group).

PII: S0016-5085(05)00188-5

doi: 10.1053/j.gastro.2005.02.019

Gastroenterology
Volume 128, Issue 4, Supplement 1 , Pages S109-S120 , April 2005