Gastroenterology
Volume 128, Issue 4, Supplement 1 , Pages S74-S78 , April 2005

The many faces of celiac disease: Clinical presentation of celiac disease in the adult population

  • Peter H.R. Green

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to Peter H. R. Green, MD, FRACP, 161 Fort Washington Avenue, New York, New York 10032. fax: (212) 305-3738.

References 

  1. Doe WF , Evans D , Hobbs JR , Booth CC . Coeliac disease, vasculitis, and cryoglobulinaemia . Gut . 1972;13:112–123
  2. Mann JG , Brown WR , Kern F . The subtle and variable clinical expressions of gluten-induced enteropathy (adult celiac disease, nontropical sprue). An analysis of twenty-one consecutive cases . Am J Med . 1970;48:357–366
  3. Campbell CB , Roberts RK , Cowen AE . The changing clinical presentation of coeliac disease in adults . Med J Aust . 1977;1:89–93
  4. Logan RF , Tucker G , Rifkind EA , Heading RC , Ferguson A . Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-79 . BMJ . 1983;286:95–97
  5. Pare P , Douville P , Caron D , Lagace R . Adult celiac sprue (changes in the pattern of clinical recognition) . J Clin Gastroenterol . 1988;10:395–400
  6. Marsh MN . Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (’celiac sprue’) . Gastroenterology . 1992;102:330–354
  7. West J, Logan RF, Hill PG, Lloyd A, Lewis S, Hubbard R, et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England . Gut . 2003;52:960–965
  8. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States (a large multicenter study) . Arch Intern Med . 2003;163:286–292
  9. Green PH , Jabri B . Coeliac disease . Lancet . 2003;362:383–391
  10. Green PHR, Stavropoulos SN, Panagi SG, Goldstein SL, McMahon DJ, Absan H, et al. Characteristics of adult celiac disease in the USA (results of a national survey) . Am J Gastroenterol . 2001;96:126–131
  11. Lo W , Sano K , Lebwohl B , Diamond B , Green PH . Changing presentation of adult celiac disease . Dig Dis Sci . 2003;48:395–398
  12. Murray JA , Van Dyke C , Plevak MF , Dierkhising RA , Zinsmeister AR , Melton LJ . Trends in the incidence and clinical features of celiac disease in a North American community, 1950-2001 . Clin Gastroenterol Hepatol . 2003;1:19–27
  13. Sanders DS, Carter MJ, Hurlstone DP, Pearce A, Ward AM, McAlindon ME, et al. Association of adult coeliac disease with irritable bowel syndrome (a case-control study in patients fulfilling ROME II criteria referred to secondary care) . Lancet . 2001;358:1504–1508
  14. Johnson TC, Diamond B, Memeo L, Negulescu H, Hovhanissyan Z, Verkarre V, et al. Relationship of HLA-DQ8 and severity of celiac disease (comparison of New York and Parisian cohorts) . Clin Gastroenterol Hepatol . 2004;2:888–894
  15. Oxentenko AS , Grisolano SW , Murray JA , Burgart LJ , Dierkhising RA , Alexander JA . The insensitivity of endoscopic markers in celiac disease . Am J Gastroenterol . 2002;97:933–938
  16. Karnam US , Felder LR , Raskin JB . Prevalence of occult celiac disease in patients with iron-deficiency anemia (a prospective study) . South Med J . 2004;97:30–34
  17. Meyer D , Stavropolous S , Diamond B , Shane E , Green PH . Osteoporosis in a north American adult population with celiac disease . Am J Gastroenterol . 2001;96:112–119
  18. Gonzalez D, Sugai E, Gomez JC, Oliveri MB, Gomez Acotto C, Vega E, et al. Is it necessary to screen for celiac disease in postmenopausal osteoporotic women? . Calcif Tissue Int . 2002;24:24
  19. Green PH , Shane E , Rotterdam H , Forde KA , Grossbard L . Significance of unsuspected celiac disease detected at endoscopy . Gastrointest Endosc . 2000;51:60–65
  20. Usai P, Bassotti G, Usai Satta P, Cherchi M, Plesa A, Boy F, et al. Oesophageal motility in adult coeliac disease . Neurogastroenterol Motil . 1995;7:239–244
  21. Shah VH , Rotterdam H , Kotler DP , Fasano A , Green PH . All that scallops is not celiac disease . Gastrointest Endosc . 2000;51:717–720
  22. Green PH , Murray JA . Routine duodenal biopsies to exclude celiac disease? . Gastrointest Endosc . 2003;58:92–95
  23. Holmes GK . Screening for coeliac disease in type 1 diabetes . Arch Dis Child . 2002;87:495–498
  24. Talal AH , Murray JA , Goeken JA , Sivitz WI . Celiac disease in an adult population with insulin-dependent diabetes mellitus (use of endomysial antibody testing) . Am J Gastroenterol . 1997;92:1280–1284
  25. Alaedini A, Green PH, Sander HW, Hays AP, Gamboa ET, Fasano A, et al. Ganglioside reactive antibodies in the neuropathy associated with celiac disease . J Neuroimmunol . 2002;127:145–148
  26. Chin RL, Sander HW, Brannagan TH, Green PH, Hays AP, Alaedini A, et al. Celiac neuropathy . Neurology . 2003;60:1581–1585
  27. Sander HW, Magda P, Chin RL, Wu A, Brannagan TH, Green PH, et al. Cerebellar ataxia and coeliac disease . Lancet . 2003;362:1548
  28. Arroyo HA , De Rosa S , Ruggieri V , de Davila MT , Fejerman N . Epilepsy, occipital calcifications, and oligosymptomatic celiac disease in childhood . J Child Neurol . 2002;17:800–806
  29. Rabsztyn A , Green PH , Berti I , Fasano A , Perman JA , Horvath K . Macroamylasemia in patients with celiac disease . Am J Gastroenterol . 2001;96:1096–1100
  30. O’Grady JG , Stevens FM , Harding B , O’Gorman TA , McNicholl B , McCarthy CF . Hyposplenism and gluten-sensitive enteropathy. Natural history, incidence, and relationship to diet and small bowel morphology . Gastroenterology . 1984;87:1326–1331
  31. Aine L . Permanent tooth dental enamel defects leading to the diagnosis of coeliac disease . Br Dent J . 1994;177:253–254
  32. Collin P , Vilska S , Heinonen PK , Hallstrom O , Pikkarainen P . Infertility and coeliac disease . Gut . 1996;39:382–384
  33. Kolho KL , Tiitinen A , Tulppala M , Unkila-Kallio L , Savilahti E . Screening for coeliac disease in women with a history of recurrent miscarriage or infertility . Br J Obstet Gynaecol . 1999;106:171–173
  34. Sher KS , Mayberry JF . Female fertility, obstetric and gynaecological history in coeliac disease. A case control study . Digestion . 1994;55:243–246
  35. Bai DR , Baer P , Holleran S , Ramakrishnan R , Green PHR . Effect of gender on the manifestations of celiac disease (evidence for greater malabsorption in men) . Scand J Gastroenterol . 2005;40:183–187
  36. Jacobson DL , Gange SJ , Rose NR , Graham NM . Epidemiology and estimated population burden of selected autoimmune diseases in the United States . Clin Immunol Immunopathol . 1997;84:223–243
  37. Ventura A , Magazzu G , Greco L  SIGEP Study Group for Autoimmune Disorders in Celiac Disease . Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease . Gastroenterology . 1999;117:297–303
  38. Green PH , Fleischauer AT , Bhagat G , Goyal R , Jabri B , Neugut AI . Risk of malignancy in patients with celiac disease . Am J Med . 2003;115:191–195
  39. Abrams JA , Diamond B , Rotterdam H , Green PH . Seronegative celiac disease (increased prevalence with lesser degrees of villous atrophy) . Dig Dis Sci . 2004;49:546–550
  40. Dahele A , Kingstone K , Bode J , Anderson D , Ghosh S . Anti-endomysial antibody negative celiac disease (does additional serological testing help?) . Dig Dis Sci . 2001;46:214–221
  41. Dickey W , Hughes DF , McMillan SA . Reliance on serum endomysial antibody testing underestimates the true prevalence of coeliac disease by one fifth . Scand J Gastroenterol . 2000;35:181–183
  42. Dickey W , McMillan SA , Hughes DF . Sensitivity of serum tissue transglutaminase antibodies for endomysial antibody positive and negative coeliac disease . Scand J Gastroenterol . 2001;36:511–514
  43. Rostami K , Kerckhaert JP , Tiemessen R , Meijer JW , Mulder CJ . The relationship between anti-endomysium antibodies and villous atrophy in coeliac disease using both monkey and human substrate . Eur J Gastroenterol Hepatol . 1999;11:439–442
  44. Tursi A , Brandimarte G , Giorgetti G , Gigliobianco A , Lombardi D , Gasbarrini G . Low prevalence of antigliadin and anti-endomysium antibodies in subclinical/silent celiac disease . Am J Gastroenterol . 2001;96:1507–1510
  45. Tursi A , Brandimarte G , Giorgetti GM . Prevalence of antitissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease . J Clin Gastroenterol . 2003;36:219–221
  46. Catassi C, Ratsch IM, Gandolfi L, Pratesi R, Fabiani E, El Asmar R, et al. Why is coeliac disease endemic in the people of the Sahara? . Lancet . 1999;354:647–648
  47. Shahbazkhani B, Malekzadeh R, Sotoudeh M, Moghadam KF, Farhadi M, Ansari R, et al. High prevalence of coeliac disease in apparently healthy Iranian blood donors . Eur J Gastroenterol Hepatol . 2003;15:475–478
  48. Sood A , Midha V , Sood N , Kaushal V , Puri H . Increasing incidence of celiac disease in India . Am J Gastroenterol . 2001;96:2804–2805
  49. Gandolfi L , Pratesi R , Cordoba JC , Tauil PL , Gasparin M , Catassi C . Prevalence of celiac disease among blood donors in Brazil . Am J Gastroenterol . 2000;95:689–692
  50. Gomez JC, Selvaggio GS, Viola M, Pizarro B, la Motta G, de Barrio S, et al. Prevalence of celiac disease in Argentina (screening of an adult population in the La Plata area) . Am J Gastroenterol . 2001;96:2700–2704
  51. Araya M, Mondragon A, Perez-Bravo F, Roessler JL, Alarcon T, Rios G, et al. Celiac disease in a Chilean population carrying Amerindian traits . J Pediatr Gastroenterol Nutr . 2000;31:381–386
  52. Sagaro E , Jimenez N . Family studies of coeliac disease in Cuba . Arch Dis Child . 1981;56:132–133
  53. Freeman HJ . Biopsy-defined adult celiac disease in Asian-Canadians . Can J Gastroenterol . 2003;17:433–436

PII: S0016-5085(05)00185-X

doi: 10.1053/j.gastro.2005.02.016

Gastroenterology
Volume 128, Issue 4, Supplement 1 , Pages S74-S78 , April 2005

Article Tools