« Previous
Next »
Gastroenterology
Volume 128, Issue 3
, Pages 654-666
, March 2005
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
References
- . The lineage decisions of helper T cells . Nat Rev Immunol . 2002;2:933–944
- . TH1-TH2 (a procrustean paradigm) . Nat Immunol . 2003;4:503–505
- . Involvement of both “allergic” and “autoimmune” mechanisms in EAE, MS and other autoimmune diseases . Trends Immunol . 2003;24:479–484
- . Cytokines and autoimmunity . Nat Rev Immunol . 2002;2:37–45
- . Inflammatory bowel disease . N Engl J Med . 2002;347:417–429
- . The immunological and genetic basis of inflammatory bowel disease . Nat Rev Immunol . 2003;3:521–533
- . Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5 . J Immunol . 1996;157:1261–1270
- . Interleukin 12 is expressed and actively released by Crohn’s disease intestinal lamina propria mononuclear cells . Gastroenterology . 1997;112:1169–1178
- . Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease . J Clin Gastroenterol . 2003;36:120–125
- . Distinct cytokine patterns in early and chronic ileal lesions of Crohn’s disease . Gastroenterology . 1997;113:118–126
- . Comprehensive analysis of intestinal cytokine messenger RNA profile by real-time quantitative polymerase chain reaction in patients with inflammatory bowel disease . Int J Mol Med . 2003;11:175–179
- . Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis . Am J Gastroenterol . 2002;97:2820–2828
- . Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease . J Clin Invest . 2001;107:695–702
- . Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis . Gastroenterology . 2003;124:972–982
- . TNF-alpha neutralization ameliorates the severity of murine Crohn’s-like ileitis by abrogation of intestinal epithelial cell apoptosis . Proc Natl Acad Sci U S A . 2003;100:8366–8371
- . The immunology of mucosal models of inflammation . Annu Rev Immunol . 2002;20:495–549
- . Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn’s disease in mice . Gastroenterology . 2001;121:1428–1436
- . Signaling and transcription in T helper development . Annu Rev Immunol . 2000;18:451–494
- . Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn’s disease . J Immunol . 2002;169:5308–5314
- . Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice . Eur J Immunol . 2004;34:1561–1569
- . Cytokine coexpression during human Th1/Th2 cell differentiation (direct evidence for coordinated expression of Th2 cytokines) . J Immunol . 2002;169:2498–2506
- . Distinct inflammatory mechanisms mediate early versus late colitis in mice . Gastroenterology . 2002;122:94–105
- . T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice . Gastroenterology . 2003;124:672–682
- . Cellular responses to interferon-gamma . Annu Rev Immunol . 1997;15:749–795
- . IL-13 effector functions . Annu Rev Immunol . 2003;21:425–456
- . Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement . Proc Natl Acad Sci U S A . 1993;90:5914–5918
- . IL-4 exacerbates disease in a Th1 cell transfer model of colitis . J Immunol . 2001;166:2793–2800
- . IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice . Nat Immunol . 2001;2:1054–1060
- . CD40L-induced IL-12 production is further enhanced by the Th2 cytokines IL-4 and IL-13 . Scand J Immunol . 2001;53:455–463
- . IL-18 is a potent coinducer of IL-13 in NK and T cells (a new potential role for IL-18 in modulating the immune response) . J Immunol . 1999;162:5070–5077
- . Cytokines in experimental colitis . Clin Exp Immunol . 1999;118:337–339
- . T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis . J Exp Med . 2002;195:71–84
- . Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo . Nat Immunol . 2002;3:852–858
- . Human intestinal mast cells produce IL-5 in vitro upon IgE receptor cross-linking and in vivo in the course of intestinal inflammatory disease . Eur J Immunol . 1999;29:1496–1503
- . Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn’s disease . Nat Genet . 2001;29:223–228
Supported by US Public Health Service/National Institutes of Health grants DK-42191, DK-44540, DK-55812 (to F.C.), and the University of Virginia Digestive Health Research Center (1P30DK67629). G.B. is a recipient of a Research Fellowship Award from the Crohn’s and Colitis Foundation of America.
PII: S0016-5085(04)02158-4
doi: 10.1053/j.gastro.2004.11.053
© 2005 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 128, Issue 3
, Pages 654-666
, March 2005

