Gastroenterology
Volume 128, Issue 2 , Pages 343-350 , February 2005

Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C

  • Laurent Castéra

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • Corresponding Author InformationAddress requests for reprints to: Laurent Castera, MD, Service d’Hépato-Gastroentérologie, Hôpital Haut Lévêque, Avenue Magellan, 33604 Pessac, France; fax: (33) 5 57 65 64 45
    • ,
  • Julien Vergniol

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • ,
  • Juliette Foucher

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • ,
  • Brigitte Le Bail

      Affiliations

    • Service d’Anatomo-Pathologie, Hôpital Pellegrin, C.H.U. Bordeaux, Bordeaux
    • INSERM E362 IFR66 Université Victor Segalen, Bordeaux, France
    • ,
  • Elise Chanteloup

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • ,
  • Maud Haaser

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • ,
  • Monique Darriet

      Affiliations

    • Laboratoire de Biochimie, Hôpital Pellegrin, C.H.U. Bordeaux, Bordeaux
    • ,
  • Patrice Couzigou

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • ,
  • Victor de Lédinghen

      Affiliations

    • Service d’Hépato-gastroentérologie, Hôpital Haut Lévêque, C.H.U. Bordeaux, Pessac
    • INSERM E362 IFR66 Université Victor Segalen, Bordeaux, France

Received 28 July 2004 ,Accepted 4 November 2004.

References 

  1. NIH Consensus Statement on Management of Hepatitis C. 2002 . Hepatology . 2002;36:S3–S20
  2. Dienstag JL . The role of liver biopsy in chronic hepatitis C . Hepatology . 2002;36:S152–S160
  3. Cadranel JF , Rufat P , Degos F . Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF) . Hepatology . 2000;32:477–481
  4. Castera L , Negre I , Samii K , Buffet C . Pain experienced during percutaneous liver biopsy . Hepatology . 1999;30:1529–1530
  5. Bravo AA , Sheth SG , Chopra S . Liver biopsy . N Engl J Med . 2001;344:495–500
  6. Maharaj B , Maharaj RJ , Leary WP , Cooppan RM , Naran AD , Pirie D , et al.   Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver . Lancet . 1986;1:523–525
  7. Regev A , Berho M , Jeffers LJ , Milikowski C , Molina EG , Pyrsopoulos NT , et al.   Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection . Am J Gastroenterol . 2002;97:2614–2618
  8. Colloredo G , Guido M , Sonzogni A , Leandro G . Impact of liver biopsy size on histological evaluation of chronic viral hepatitis (the smaller the sample, the milder the disease) . J Hepatol . 2003;39:239–244
  9. Bedossa P , Dargère D , Paradise V . Sampling variability of liver fibrosis in chronic hepatitis C . Hepatology . 2003;38:1449–1457
  10. Siddique I , El-Naga HA , Madda JP , Memon A , Hasan F . Sampling variability on percutaneous liver biopsy in patients with chronic hepatitis C virus infection . Scand J Gastroenterol . 2003;38:427–432
  11. The French METAVIR Cooperative Study Group . Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C . Hepatology . 1994;20:15–20
  12. Fontana RJ , Lok AS . Noninvasive monitoring of patients with chronic hepatitis C . Hepatology . 2002;36:S57–S64
  13. Oberti F , Valsesia E , Pilette C , Rousselet MC , Bedossa P , Aube C , et al.   Noninvasive diagnosis of hepatic fibrosis or cirrhosis . Gastroenterology . 1997;113:1609–1616
  14. Wai CT , Greenson JK , Fontana RJ , Kalbfleisch JD , Marrero JA , Conjeevaram HS , et al.   A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C . Hepatology . 2003;38:518–526
  15. Imbert-Bismut F , Ratziu V , Pieroni L , Charlotte F , Benhamou Y , Poynard T . Biochemical markers of liver fibrosis in patients with hepatitis C virus infection (a prospective study) . Lancet . 2001;357:1069–1075
  16. Forns X , Ampurdanes S , Llovet JM , Aponte J , Quinto L , Martinez-Bauer E , et al.   Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model . Hepatology . 2002;36:986–992
  17. Patel K , Lajoie A , Heaton S , Pianko S , Behling CA , Bylund D , et al.   Clinical use of hyaluronic acid as a predictor of fibrosis change in hepatitis C . J Gastroenterol Hepatol . 2003;18:253–257
  18. Guechot J , Laudat A , Loria A , Serfaty L , Poupon R , Giboudeau J . Diagnostic accuracy of hyaluronan and type III procollagen amino-terminal peptide serum assays as markers of liver fibrosis in chronic viral hepatitis C evaluated by ROC curve analysis . Clin Chem . 1996;42:558–563
  19. Callewaert N , Van Vlierberghe H , Van Hecke A , Laroy W , Delanghe J , Contreras R . Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics . Nat Med . 2004;10:429–434
  20. Sandrin L , Fourquet B , Hasquenoph JM , Yon S , Fournier C , Mal F , et al.   Transient elastography (a new noninvasive method for assessment of hepatic fibrosis) . Ultrasound Med Biol . 2003;29:1705–1713
  21. Beaugrand M , Ziol M , Sandrin L , Fournier C , Biaggi-Frassati A , Poulet B , et al.   Liver elasticity measurement by ultrasonic transient elastography (a new non-invasive method for assessment of liver fibrosis in chronic viral hepatitis (abstr)) . Hepatology . 2003;38(suppl 1):438A
  22. Saito H , Tada S , Nakamoto N , Kitamura K , Horikawa H , Kurita S , et al.   Efficacy of non-invasive elastometry on staging of hepatic fibrosis . Hepatol Res . 2004;29:97–103
  23. Menghini G . One-second biopsy of the liver—problems of its clinical application . N Engl J Med . 1970;283:582–585
  24. Marcovina SM , Albers JJ , Henderson LO , Hannon WH . International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B. III. Comparability of apolipoprotein A-I values by use of international reference material . Clin Chem . 1993;39:773–781
  25. Dati F , Schumann G , Thomas L , Aguzzi F , Baudner S , Bienvenu J , et al.   Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC/BCR/CAP Reference Material (CRM 470). International Federation of Clinical Chemistry. Community Bureau of Reference of the Commission of the European Communities. College of American Pathologists . Eur J Clin Chem Clin Biochem . 1996;34:517–520
  26. Imbert-Bismut F , Messous D , Thibaut V , Myers RB , Piton A , Thabut D , et al.   Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors . Clin Chem Lab Med . 2004;42:323–333
  27. Poynard T . Diagnosis method of inflammatory, fibrotic or cancerous disease using the biochemical markers . 2003; United States: Patent No US 6,631,330 B1
  28. Bedossa P , Poynard T  The METAVIR cooperative study group . An algorithm for the grading of activity in chronic hepatitis C . Hepatology . 1996;24:289–293
  29. Myers RP , Ratziu V , Imbert-Bismut F , Charlotte F , Poynard T . Biochemical markers of liver fibrosis (a comparison with historical features in patients with chronic hepatitis C) . Am J Gastroenterol . 2002;97:2419–2425
  30. Myers RP , De Torres M , Imbert-Bismut F , Ratziu V , Charlotte F , Poynard T . Biochemical markers of fibrosis in patients with chronic hepatitis C (a comparison with prothrombin time, platelet count, and age-platelet index) . Dig Dis Sci . 2003;48:146–153
  31. Poynard T , Imbert-Bismut F , Ratziu V , Chevret S , Jardel C , Moussalli J , et al.   Biochemical markers of liver fibrosis in patients infected by hepatitis C virus (longitudinal validation in a randomized trial) . J Viral Hepat . 2002;9:128–133
  32. Poynard T , McHutchison J , Manns M , Myers RP , Albrecht J . Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin . Hepatology . 2003;38:481–492
  33. Poynard T , Munteanu M , Imbert-Bismut F , Charlotte F , Thabut D , Le Calvez S , et al.   Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C . Clin Chem . 2004;10:10
  34. Gebo KA , Herlong HF , Torbenson MS , Jenckes MW , Chander G , Ghanem KG , et al.   Role of liver biopsy in management of chronic hepatitis C (a systematic review) . Hepatology . 2002;36:S161–S172
  35. Afdhal NH . Diagnosing fibrosis in hepatitis C (is the pendulum swinging from biopsy to blood tests?) . Hepatology . 2003;37:972–974
  36. Ziol M , Barget N , Sandrin L , Fournier C , Mal F , Kazemi F , et al.   Correlation between liver elasticity measured by transient elastography and liver fibrosis assessed by morphometry in patients with HCV chronic hepatitis (abstr) . J Hepatol . 2004;40(suppl 1):459
  37. Rossi E , Adams L , Prins A , Bulsara M , de Boer B , Garas G , et al.   Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients . Clin Chem . 2003;49:450–454
  38. Thabut D , Simon M , Myers RP , Messous D , Thibault V , Imbert-Bismut F , et al.   Noninvasive prediction of fibrosis in patients with chronic hepatitis C . Hepatology . 2003;37:1220–1221
  39. Halfon P , Bourliere M , Deydier R , Portal I , Renou C , Bertrand JJ , et al.   Independent prospective multicenter validation of biochemical markers (Fibrotest-Actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C (abstr) . Hepatology . 2003;38(suppl 1):188A
  40. Le Calvez S , Thabut D , Messous D , Munteanu M , Ratziu V , Imbert-Bismut F , et al.   The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C . Hepatology . 2004;39:862–863

 The Fibroscan devices were made available for the study by Echosens (Paris, France).

PII: S0016-5085(04)02029-3

doi: 10.1053/j.gastro.2004.11.018

Gastroenterology
Volume 128, Issue 2 , Pages 343-350 , February 2005

Article Tools

* Image Usage & Resolution