Gastroenterology
Volume 128, Issue 1 , Pages 169-174 , January 2005

Endosonographic diagnosis of recurrent gastrointestinal stromal tumors associated with Carney’s syndrome

  • Michael T. Lipcan III

      Affiliations

    • Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  • ,
  • David E. Loren

      Affiliations

    • Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  • ,
  • Juan P. Palazzo

      Affiliations

    • Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  • ,
  • Marluce Bibbo

      Affiliations

    • Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  • ,
  • Anthony J. Dimarino

      Affiliations

    • Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  • ,
  • Sidney Cohen

      Affiliations

    • Corresponding Author InformationAddress requests for reprint to: Sidney Cohen, MD, Professor of Medicine, Division of Gastroenterology and Hepatology, Director of Research Programs, Thomas Jefferson University, 132 South 10th Street, 480 Main Building, Philadelphia, Pennsylvania 19107-5244. fax: (215) 503-2527.
    • Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

Received 2 May 2004 ,Accepted 7 October 2004.

References 

  1. Carney JA , Sheps SG , Go VW , Gordon H . The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma . N Engl J Med . 1977;296:1517–1518
  2. Appelman HD . Smooth muscle tumors of the gastrointestinal tract (what we know and what Stout didn’t know) . Am J Surg Pathol . 1986;10(Suppl 1):83–99
  3. Carney JA . Gastric stromal sarcoma, pulmonary chondroma and extra-adrenal paraganglioma (Carney’s triad) (natural history, adrenocortical component and possible familial occurrence) . Mayo Clin Proc . 1999;74:543–552
  4. Stout AP . Bizarre smooth muscle tumors of the stomach . Cancer . 1962;38:400–409
  5. Kindblom LG , Meis-Kindblom JM , Havel G , Busch C . Gastrointestinal pacemaker cell tumor (GIPAC) (gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal) . Am J Pathol . 1998;152:1259–1269
  6. Sarlomo-Rikala M , Kovatich AJ , Barusevicius A , Miettinen M . CD 117 (a sensitive marker for gastrointestinal stromal tumors that is more specific than CD 34) . Mod Pathol . 1998;11:728–734
  7. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors . Science . 1998;279:577–580
  8. Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors (short communication) . Am J Pathol . 2000;156:791–795
  9. Lasota J , Jasinski M , Sarlomo-Rikala M , Miettinen M . Mutations in exon 11 of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas . Am J Pathol . 1999;154:53–60
  10. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, et al. Effect of the tyrosine kinase inhibitor STI-571 in a patient with metastatic gastrointestinal stromal tumor . N Engl J Med . 2001;344:1052–1056
  11. Dagher R, Cohen M, Williams G, Rothmann M, Gobburu J, Robbie G, et al. Approval summary (imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors) . Clin Cancer Res . 2002;8:3034–3038
  12. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors (a consensus approach) . Hum Pathol . 1999;33:1213–1220
  13. Miettinen M , Sarlomo-Rikala M , Lasota J . Gastrointestinal stromal tumors (recent advances in understanding their biology) . Hum Pathol . 1999;30:934–942
  14. Boyce GA, Sivak MV, Lavery IC, Fazio VW, Church JM, Milsom J, et al. Evaluation of submucosal upper gastrointestinal tract lesions by endoscopic ultrasound . Gastrointest Endosc . 1991;37:449–454
  15. Davila RE , Faigel D . GI stromal tumors . Gastrointest Endosc . 2003;58:80–88
  16. Ando N, Goto H, Niwa Y, Hirooka Y, Ohmiya N, Nagasaka T, et al. The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis . Gastrointest Endosc . 2002;55:37–43
  17. Gu M , Ghafari S , Nguyen PT , Lin F . Cytologic diagnosis of gastrointestinal stromal tumors of the stomach by endoscopic ultrasound-guided fine-needle aspiration biopsy . Diagn Cytopathol . 2001;25:343–350
  18. DeMatteo RP , Lewis JJ , Leung D , Mudan SS , Woodruff JM , Brennan MF . Two hundred gastrointestinal stromal tumors (recurrence patterns and prognostic factors for survival) . Ann Surg . 2000;231:51–58
  19. Emory TS , Sobin L , Lukes L , Lee DH , O’Leary TJ . Prognosis of gastrointestinal smooth-muscle (stromal) tumors dependence on anatomic site . Am J Surg Pathol . 1999;23:82–87
  20. Scopsi L , Collini P , Muscolino C . A new observation of the Carney’s triad with long follow-up period and additional tumors . Cancer Detect Prev . 1999;23:435–442
  21. Abdulkader I, Cameselle-Teijeiro J, Gude F, Frage M, Varela-Duran J, Barreirro F, et al. Predictors of malignant behavior in gastrointestinal stromal tumors (a clinicopathological study of 34 patients) . Eur J Surg . 2002;168:288–295
  22. Miettinen M , El-rifai W , Sobin L , Lasota J . Evaluation of malignancy and prognosis of gastrointestinal stomal tumors (a review) . Hum Pathol . 2002;33:478–482
  23. Palazzo L , Landi B , Cellier C , Cuillerier E , Rosseau G , Barbier JP . Endosonographic features predictive of benign and malignant gastrointestinal stromal cell tumours . Gut . 2000;46:88–92
  24. Chak A, Canto MI, Rosch T, Dittler HJ, Hawes RH, Tio TL, et al. Endosonographic differentiation of benign and malignant stromal cell tumors . Gastrointest Endosc . 1997;45:468–473
  25. Montgomery E, Abraham SC, Fisher C, Deasel MR, Amr SS, Sheikh SS, et al. CD44 loss in gastric stromal tumors as a prognostic marker . Am J Pathol . 2004;28:168–177
  26. Berman J , O’Learry TJ . Gastrointestinal stromal tumor workshop . Hum Pathol . 2001;32:578–582
  27. Valverde K , Henderson M , Smith CR , Tallett S , Chan HS . Typical and atypical Carney’s triad presenting with malignant hypertension and papilledema . J Pediatr Hematol Oncol . 2001;23:519–524
  28. Wahid ST , Jones R , Chawla SL , Connolly VM , Kelly WF , Bilous RW . A new variant of Carney’s triad (phaeochromocytoma and chondrosarcoma) . Postgrad Med J . 2001;77:527–528
  29. Dajee A , Dajee H , Hinrichs S , Lillington G . Pulmonary chrondroma, extra-adrenal paraganglioma, and gastric leiomyosarcoma (Carney’s triad) . J Thorac Cardvasc Surg . 1982;84:377–381
  30. Erb RE , Delbeke D , Falke TH , Sandler MP . Magnetic resonance imaging of Carney’s triad . South Med J . 1994;87:951–955
  31. McEwan AJ , Shapiro B , Sisson JC , Beierwaltes WH , Ackerty DM . Radio-iodobenzylguanidine for the scintigraphic localization and therapy of adrenergic tumors . Semin Nuclear Med . 1985;15:132–150
  32. Kwekkeboom DJ, van Urk H, Pauw BK, Lamberts SW, Kooij PP, Hoogma RP, et al. Octreotide scinitgraphy for the detection of paragangliomas . J Nucl Med . 1993;34:873–887
  33. Reubi JC , Waser B , Khosla S , et al.   In vitro and in vivo detection of somatostatin receptors in pheochromocytomas and paragangliomas . J Clin Endocrinol Metab . 1992;74:1082–1089
  34. Margulies KB . Carney’s triad (guidelines for management) . Mayo Clin Proc . 1988;63:496–502

PII: S0016-5085(04)01992-4

doi: 10.1053/j.gastro.2004.10.042

Gastroenterology
Volume 128, Issue 1 , Pages 169-174 , January 2005