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Gastroenterology
Volume 128, Issue 7
, Pages 2131-2146
, June 2005
The Role of Protein Kinase C in Gastrointestinal Function and Disease
References
- . Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases . Science . 2002;298:1911–1912
- . Protein kinase C isozymes and the regulation of diverse cell responses . Am J Physiol Lung Cell Mol Physiol . 2000;279:L429–L438
- . Nuclear protein kinase C isoforms (key players in multiple cell functions?) . Histol Histopathol . 2003;18:1301–1312
- . Multiple biological responses activated by nuclear protein kinase C . J Cell Biochem . 1999;74:499–521
- . The role of protein kinase C isoforms in cell proliferation and apoptosis . Int J Hematol . 2000;72:12–19
- . Protein kinase C (structure, function, and regulation) . J Biol Chem . 1995;270:28495–28498
-
.
Signaling through protein kinase C
.
Front Biosci
. 1998;3:D1134–D1147
- . Regulation of protein kinase C . Curr Opin Cell Biol . 1997;9:161–167
- . Regulation of the ABC kinases by phosphorylation (protein kinase C as a paradigm) . Biochem J . 2003;370:361–371
- . Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells . J Biol Chem . 1989;264:13902–13909
- . Determination of in vivo phosphorylation sites in protein kinase C . J Biol Chem . 1995;270:26807–26812
- . Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 . Curr Biol . 1998;8:1069–1077
- . Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) . Curr Biol . 1998;8:1366–1375
- . Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 . Science . 1998;281:2042–2045
- . Structural aspects of the functional modules in human protein kinase-C α deduced from comparative analyses . Proteins . 1996;26:217–235
- . Intrapeptide regulation of protein kinase C . J Biol Chem . 1994;269:8383–8387
- . Protein kinase C isoforms in the enteric nervous system . Histochem Cell Biol . 2003;120:51–61
- . Ca(2+)-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence . Trends Biochem Sci . 1993;18:207–208
- . PKC-α shows variable patterns of translocation in response to different stimulatory agents . Acta Physiol Scand . 2002;174:237–246
- . PKCα translocation is microtubule-dependent in passaged smooth muscle cells . Acta Physiol Scand . 2000;170:87–97
- . Intracellular targeting and protein kinase C in vascular smooth muscle cells (specific effects of different membrane-bound receptors) . Acta Physiol Scand . 1998;164:599–609
- . Integrin-induced protein kinase Cα and Cϵ translocation to focal adhesions mediates vascular smooth muscle cell spreading . Circ Res . 1998;82:157–165
- . The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1 . J Biol Chem . 2001;276:20346–20356
- . RACK1 (a novel substrate for the Src protein-tyrosine kinase) . Oncogene . 2002;21:7619–7629
- . Divergence and complexities in DAG signaling (looking beyond PKC) . Trends Pharmacol Sci . 2003;24:602–608
- . The role of protein kinase C isozymes in TNF-α-induced cytotoxicity to a rat intestinal epithelial cell line . Am J Physiol Gastrointest Liver Physiol . 2001;280:G572–G583
- . A critical intramolecular interaction for protein kinase C(epsilon) translocation . J Biol Chem . 2004;279:15831–15840
-
.
RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release
.
PNAS
. 2004;101:2328–2332
- . Nuclear targeting signal recognition (a key control point in nuclear transport?) . Bioessays . 2000;22:532–544
- . Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebra fish organogenesis . Curr Biol . 2001;11:1492–1502
- . Organogenesis of the Caenorhabditis elegans intestine . Dev Biol . 1999;216:114–134
- . Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul . Curr Biol . 2001;11:1481–1491
- . Dysmorphogenic effects of a specific protein kinase C inhibitor during neurulation . Reprod Toxicol . 1998;12:525–534
- . Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins . Am J Physiol Cell Physiol . 2003;285:C300–C309
- . Signalling to and from tight junctions . Nat Rev Mol Cell Biol . 2003;4:225–236
- . Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A . J Biol Chem . 2002;277:4247–4254
- . Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans . Development . 1998;125:3607–3614
- . Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism . J Biol Chem . 1998;273:1130–1143
- . Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy . Diabetes . 2002;51:2804–2810
- . Intestinal epithelial responses to enteric pathogens (effects on the tight junction barrier, ion transport, and inflammation) . Gut . 2003;52:439–451
- . PKC ζ participates in activation of inflammatory response induced by enteropathogenic E coli . Am J Physiol Cell Physiol . 2003;285:C512–C521
- . Activation of host cell protein kinase C by enteropathogenic Escherichia coli . Infect Immun . 1997;65:3277–3285
- . Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators . Infect Immun . 1998;66:2943–2950
- . Function for NF-κB in neuronal survival (regulation by atypical protein kinase C) . J Neurosci Res . 1999;58:607–611
- . Regulation of neutrophil apoptosis (a role for protein kinase C and phosphatidylinositol-3-kinase) . Apoptosis . 2000;5:451–458
- . Protein kinase C mediates experimental colitis in the rat . Am J Physiol . 1999;276:G583–G590
- . Protein kinase C and calcineurin synergize to activate IκB kinase and NF-κB in T lymphocytes . J Biol Chem . 1999;274:22923–22931
- . Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases . Curr Mol Med . 2001;1:739–754
- . Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis . J Biol Chem . 2002;277:22595–22604
- . Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-δ . J Biol Chem . 1999;274:37329–37334
- . PKCδ-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate . Eur J Biochem . 2003;270:4089–4094
- . Protein kinase C activity of colonic mucosa in ulcerative colitis . Scand J Gastroenterol . 1992;27:275–280
- . Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C . Am J Physiol . 1997;272:G1109–G1115
- . Protein kinase C mediates lipopolysaccharide- and phorbol-induced nitric-oxide synthase activity and cellular injury in the rat colon . J Pharmacol Exp Ther . 2000;295:1249–1257
- . Protein kinase Cδ activation by interleukin-1β stabilizes inducible nitric-oxide synthase mRNA in pancreatic β-cells . J Biol Chem . 2001;276:5368–5374
- . Alterations in protein kinase C isoforms in experimentally-induced colitis in the rat . Inflamm Res . 2000;49:27–35
- . PKC-ζ is required in EGF protection of microtubules and intestinal barrier integrity against oxidant injury . Am J Physiol Gastrointest Liver Physiol . 2002;282:G794–G808
- . PKC-β1 mediates EGF protection of microtubules and barrier of intestinal monolayers against oxidants . Am J Physiol Gastrointest Liver Physiol . 2001;281:G833–G847
- . Zeta isoform of protein kinase C prevents oxidant-induced nuclear factor-κB activation and I-κBα degradation (a fundamental mechanism for epidermal growth factor protection of the microtubule cytoskeleton and intestinal barrier integrity) . J Pharmacol Exp Ther . 2003;307:53–66
- . Key role of PKC and Ca2+ in EGF protection of microtubules and intestinal barrier against oxidants . Am J Physiol Gastrointest Liver Physiol . 2001;280:G828–G843
- . PKC-ζ prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity . Am J Physiol Gastrointest Liver Physiol . 2002;283:G909–G922
- . Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease . Gut . 2003;52:720–728
- . Ethanol differentially regulates NF-κB activation in pancreatic acinar cells through calcium and protein kinase C pathways . Am J Physiol Gastrointest Liver Physiol . 2004;286:G204–G213
- . Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells . Annu Rev Physiol . 2001;63:77–97
- . PKC-δ and -ϵ regulate NF-κB activation induced by cholecystokinin and TNF-α in pancreatic acinar cells . Am J Physiol Gastrointest Liver Physiol . 2004;287:G582–G591
- . Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms . Am J Physiol Cell Physiol . 2001;281:C649–C661
- . Inhibition of apical Cl−/OH− exchange activity in Caco-2 cells by phorbol esters is mediated by PKCϵ . Am J Physiol Cell Physiol . 2002;283:C1492–C1500
- . PKC-ϵ regulates basolateral endocytosis in human T84 intestinal epithelia (role of F-actin and MARCKS) . Am J Physiol . 1999;277:C1239–C1249
- . Opposing effects of PKCα and PKCϵ on basolateral membrane dynamics in intestinal epithelia . Am J Physiol Cell Physiol . 2002;283:C1548–C1556
-
.
Intestinal water and electrolyte transport
.
In:
Johnson LR
editors.
Physiology of the gastrointestinal tract
. 2nd ed.. New York: Raven; 1987;p. 1267–1305
- . Regulation of activity and apical targeting of the Cl−/HCO3− exchanger in rat hepatocytes . Proc Natl Acad Sci U S A . 1994;91:792–796
- . Ca2+-independent protein kinase C isoforms may modulate parietal cell HCl secretion . Am J Physiol . 1997;272:G246–G256
- . Murine colonic mucosa hyperproliferation. II. PKC-β activation and cPKC-mediated cellular CFTR over expression . Am J Physiol Gastrointest Liver Physiol . 2000;278:G765–G774
- . Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells . Biochem J . 1985;232:609–611
- . Protein kinase C and parietal cell function . Biochem Biophys Res Commun . 1987;149:720–728
- . Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells . Can J Physiol Pharmacol . 1987;65:1840–1847
- . Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells . Biochem Pharmacol . 1993;46:583–588
- . Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro . Am J Physiol Gastrointest Liver Physiol . 2004;286:G814–G821
- . Differential regulation of the expression of Na(+)/H(+) exchanger isoform NHE3 by PKC-α in Caco-2 cells . Am J Physiol Cell Physiol . 2001;281:C1551–C1558
- . Half-lives of plasma membrane Na(+)/H(+) exchangers NHE1-3 (plasma membrane NHE2 has a rapid rate of degradation) . Am J Physiol Cell Physiol . 2001;281:C2039–C2048
- . Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways . J Biol Chem . 1995;270:29209–29216
- . Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism . J Biol Chem . 2003;278:16494–16501
- . Rapid association of protein kinase C-ϵ with insulin granules is essential for insulin exocytosis . J Biol Chem . 2003;278:44753–44757
- . Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-ϵ . Am J Physiol . 1999;277:G1041–G1047
- . Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini . Pancreas . 2002;25:57–62
- . Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini . Am J Physiol . 1999;276:G915–G923
-
.
Secretory functions of the alimentary tract
. Philadelphia: W.B. Saunders; 1991;
- . Endocrine gene neurotensin (molecular mechanisms and a model of intestinal differentiation) . World J Surg . 2002;26:799–805
- . Phorbol ester-mediated neurotensin secretion is dependent on the PKC-α and -δ isoforms . Am J Physiol Gastrointest Liver Physiol . 2002;283:G1197–G1206
- . Differential signalling by muscarinic receptors in smooth muscle (m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway) . Biochem J . 2003;374:145–155
- . Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions . Am J Physiol Gastrointest Liver Physiol . 2003;284:G789–G797
- . Sustained muscle contraction induced by agonists, growth factors, and Ca(2+) mediated by distinct PKC isozymes . Am J Physiol Gastrointest Liver Physiol . 2000;279:G201–G210
- . Myosin light chain kinase- and PKC-dependent contraction of LES and esophageal smooth muscle . Am J Physiol Gastrointest Liver Physiol . 2001;281:G467–G478
- . Phorbol-stimulated Ca(2+) mobilization and contraction in dispersed intestinal smooth muscle cells . J Pharmacol Exp Ther . 2000;294:991–996
- . MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle . Am J Physiol Gastrointest Liver Physiol . 2003;285:G86–G95
- . Impairment of Ca(2+) mobilization in circular muscle cells of the inflamed colon . Am J Physiol Gastrointest Liver Physiol . 2000;278:G234–G242
- . Selective modulation of PKC isozymes by inflammation in canine colonic circular muscle cells . Gastroenterology . 2002;122:483–494
- . Ultrastructural modifications of intercellular junctions between tumor cells . In Vitro . 1970;6:15–20
- . Protein kinase C isozymes in colon carcinogenesis (guilt by omission) . Gastroenterology . 2001;120:1868–1872
- . Localization of protein kinase C isozymes in rat colon . Cell Growth Differ . 1995;6:1381–1386
- . Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control . Gastroenterology . 1996;110:1753–1759
- . Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes . Gastroenterology . 1998;115:75–85
- . Protein kinase C-mediated regulation of the cell cycle . Front Biosci . 2000;5:D406–D423
- . Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells . J Biol Chem . 1997;272:9424–9435
- . Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ . J Cell Biol . 1994;126:747–763
- . PKC-δ inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells . Gastroenterology . 2001;120:1700–1712
- . ANG II stimulates PKC-dependent ERK activation, DNA synthesis, and cell division in intestinal epithelial cells . Am J Physiol Gastrointest Liver Physiol . 2003;285:G1–G11
- . Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1 . Cancer Res . 2003;63:2379–2387
- . 1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon . Cancer Res . 1990;50:3915–3920
- . Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas . Cancer Res . 1987;47:2036–2039
- . Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon . Carcinogenesis . 1994;15:779–782
- . Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas . Cancer Res . 1991;51:205–210
- . Elevated protein kinase C βII is an early promotive event in colon carcinogenesis . Cancer Res . 2001;61:1375–1381
- . Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the η and δ isoforms of protein kinase C . Mol Cell Biol . 1998;18:5199–5207
- . Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis (potential roles of protein kinase C-α, -β II, and -ζ) . Cancer Res . 1995;55:5257–5264
- . Lessons from hereditary colorectal cancer . Cell . 1996;87:159–170
- . Life (and death) in a malignant tumour . Nature . 1996;379:19–20
- . Beta-catenin—a linchpin in colorectal carcinogenesis? . Am J Pathol . 2002;160:389–401
- . Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids . Int J Cancer . 1995;61:35–39
- . Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis . J Cell Biol . 1999;145:699–711
- . Role of cyclooxygenase 2 in protein kinase C β II-mediated colon carcinogenesis . J Biol Chem . 2003;278:11167–11174
- . Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis . Carcinogenesis . 1997;18:721–730
- . The effect of dietary omega-3 fatty acids (fish oil) on azoxymethanol-induced focal areas of dysplasia and colon tumor incidence . Cancer . 1990;66:2350–2356
- . Protein kinase C βII and TGFβRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis . J Cell Biol . 2002;157:915–920
- . Effect of diets high in omega-3 and omega-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis . Cancer Res . 1991;51:487–491
- . Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid . Cancer Res . 1993;53:2786–2789
- . Morphodensitometric analysis of protein kinase C β(II) expression in rat colon (modulation by diet and relation to in situ cell proliferation and apoptosis) . Carcinogenesis . 2000;21:1513–1519
- . Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa . Br J Nutr . 2000;84:635–643
- . Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice (relation to β-catenin and PKC isozymes) . Carcinogenesis . 2000;21:1167–1173
- . COX-2 in large bowel cancer (a one-sided story) . Gut . 1999;45:636–637
- . Is cyclooxygenase-2 the α and the ω in cancer? . J Clin Invest . 2000;105:1511–1513
- . The relationship between cyclooxygenase-2 expression and colorectal cancer . JAMA . 1999;282:1254–1257
- . The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis . N Engl J Med . 2000;342:1946–1952
- . Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps . Arch Pathol Lab Med . 2002;126:829–836
- . Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10−/− mice . Gastroenterology . 2000;118:337–345
- . Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2) . Cell . 1996;87:803–809
- . Subepithelial myofibroblasts express COX-2 in colorectal tubular adenomas . Clin Cancer Res . 2004;10:5870–5879
- . IL-1α-induced COX-2 expression in human intestinal myofibroblasts is dependent on a PKCζ-ROS pathway . Gastroenterology . 2003;124:1855–1865
- . Regulation of COX-2 expression in human intestinal myofibroblasts (mechanisms of IL-1-mediated induction) . Am J Physiol Cell Physiol . 2002;282:C824–C834
- . Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo . J Cell Biol . 2004;164:797–802
- . Protein kinase C β II induces cell invasion through a RAS/MEK-, PKC /RAC 1-dependent signaling pathway . J Biol Chem . 2004;279:22118–22123
- . High PKC α and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells . Mol Biol Cell . 2001;12:1973–1982
PII: S0016-5085(04)01747-0
doi: 10.1053/j.gastro.2004.09.078
© 2005 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 128, Issue 7
, Pages 2131-2146
, June 2005

