Gastroenterology
Volume 128, Issue 1 , Pages 24-32 , January 2005

Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States

  • Constance E. Ruhl

      Affiliations

    • Social and Scientific Systems, Inc, Silver Spring
    • Corresponding Author InformationAddress requests for reprints to: Constance E. Ruhl, MD, PhD, Social and Scientific Systems, Inc, 8757 Georgia Avenue, 12th Floor, Silver Spring, Maryland 20910. fax: (301) 628-3201.
  • ,
  • James E. Everhart

      Affiliations

    • National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland

Received 1 April 2004 ,Accepted 16 September 2004.

References 

  1. He P , Noda Y , Sugiyama K . Suppression of lipopolysaccharide-induced liver injury by various types of tea and coffee in D-galactosamine-sensitized rats . Biosci Biotechnol Biochem . 2001;65:670–673
  2. Huber WW, Scharf G, Rossmanith W, Prustomersky S, Grasl-Kraupp B, Peter B, et al. The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat . Arch Toxicol . 2002;75:685–694
  3. Scharf G , Prustomersky S , Huber WW . Elevation of glutathione levels by coffee components and its potential mechanisms . Adv Exp Med Biol . 2001;500:535–539
  4. Lee KG , Mitchell A , Shibamoto T . Antioxidative activities of aroma extracts isolated from natural plants . Biofactors . 2000;13:173–178
  5. Arnesen E , Huseby NE , Brenn T , Try K . The Tromso Heart Study (distribution of, and determinants for, gamma-glutamyltransferase in a free-living population) . Scand J Clin Lab Invest . 1986;46:63–70
  6. Nilssen O , Forde OH , Brenn T . The Tromso Study. Distribution and population determinants of gamma-glutamyltransferase . Am J Epidemiol . 1990;132:318–326
  7. Casiglia E , Spolaore P , Ginocchio G , Ambrosio GB . Unexpected effects of coffee consumption on liver enzymes . Eur J Epidemiol . 1993;9:293–297
  8. Kono S , Shinchi K , Imanishi K , Todoroki I , Hatsuse K . Coffee and serum gamma-glutamyltransferase (a study of self-defense officials in Japan) . Am J Epidemiol . 1994;139:723–727
  9. Nilssen O , Forde OH . Seven-year longitudinal population study of change in gamma-glutamyltransferase (the Tromso Study) . Am J Epidemiol . 1994;139:787–792
  10. Sharp DS , Benowitz NL . Re: “Alcohol, smoking, coffee, and cirrhosis” and “coffee and serum gamma-glutamyltransferase: a study of self-defense officials in Japan” . Am J Epidemiol . 1995;141:480–482
  11. Pintus F , Mascia P . Distribution and population determinants of gamma-glutamyltransferase in a random sample of Sardinian inhabitants. ‘ATS-SARDEGNA’ Research Group . Eur J Epidemiol . 1996;12:71–76
  12. Poikolainen K , Vartiainen E . Determinants of gamma-glutamyltransferase (positive interaction with alcohol and body mass index, negative association with coffee) . Am J Epidemiol . 1997;146:1019–1024
  13. Tanaka K, Tokunaga S, Kono S, Tokudome S, Akamatsu T, Moriyama T, et al. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers . Int J Epidemiol . 1998;27:438–443
  14. Honjo S, Kono S, Coleman MP, Shinchi K, Sakurai Y, Todoroki I, et al. Coffee drinking and serum gamma-glutamyltransferase (an extended study of Self-Defense Officials of Japan) . Ann Epidemiol . 1999;9:325–331
  15. Nakanishi N , Nakamura K , Nakajima K , Suzuki K , Tatara K . Coffee consumption and decreased serum gamma-glutamyltransferase (a study of middle-aged Japanese men) . Eur J Epidemiol . 2000;16:419–423
  16. Nakanishi N , Nakamura K , Suzuki K , Tatara K . Lifestyle and the development of increased serum gamma-glutamyltransferase in middle-aged Japanese men . Scand J Clin Lab Invest . 2000;60:429–438
  17. Nakanishi N , Nakamura K , Suzuki K , Tatara K . Lifestyle and serum gamma-glutamyltransferase (a study of middle-aged Japanese men) . Occup Med (Lond) . 2000;50:115–120
  18. Nakanishi N , Nakamura K , Suzuki K , Tatara K . Effects of coffee consumption against the development of liver dysfunction (a 4-year follow-up study of middle-aged Japanese male office workers) . Ind Health . 2000;38:99–102
  19. Honjo S, Kono S, Coleman MP, Shinchi K, Sakurai Y, Todoroki I, et al. Coffee consumption and serum aminotransferases in middle-aged Japanese men . J Clin Epidemiol . 2001;54:823–829
  20. Corrao G, Lepore AR, Torchio P, Valenti M, Galatola G, D’Amicis A, et al. The effect of drinking coffee and smoking cigarettes on the risk of cirrhosis associated with alcohol consumption. A case-control study. Provincial Group for the Study of Chronic Liver Disease . Eur J Epidemiol . 1994;10:657–664
  21. Corrao G , Zambon A , Bagnardi V , D’Amicis A , Klatsky A . Coffee, caffeine, and the risk of liver cirrhosis . Ann Epidemiol . 2001;11:458–465
  22. Gallus S , Tavani A , Negri E , La Vecchia C . Does coffee protect against liver cirrhosis? . Ann Epidemiol . 2002;12:202–205
  23. Klatsky AL , Armstrong MA . Alcohol, smoking, coffee, and cirrhosis . Am J Epidemiol . 1992;136:1248–1257
  24. Tverdal A , Skurtveit S . Coffee intake and mortality from liver cirrhosis . Ann Epidemiol . 2003;13:419–423
  25. Spiller MA . The chemical components of coffee . Prog Clin Biol Res . 1984;158:91–147
  26. Meltzer AA , Everhart JE . Association between diabetes and elevated serum alanine aminotransferase activity among Mexican Americans . Am J Epidemiol . 1997;146:565–571
  27. Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94 (DHHS Publication No. [PHS] 94-1308). National Center for Health Statistics, 1994.
  28. Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, et al. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group . Gut . 1997;41:845–850
  29. Ruhl CE , Everhart JE . Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States . Gastroenterology . 2003;124:71–79
  30. Third National Health and Nutrition Examination Survey, 1988–1994, reference manuals and reports. manual for medical technicians and laboratory procedures used for NHANES III . Hyattsville, MD: National Center for Health Statistics; 1996;
  31. Hernandez-Avila M , Colditz GA , Stampfer MJ , Rosner B , Speizer FE , Willett WC . Caffeine, moderate alcohol intake, and risk of fractures of the hip and forearm in middle-aged women . Am J Clin Nutr . 1991;54:157–163
  32. National Health and Nutrition Examination Survey III; body measurements (anthropometry) . Westat; 1988;
  33. Research Triangle Institute . SUDAAN user’s manual release 7.0 . Research Triangle Institute Park, NC: Research Triangle Institute; 1996; April
  34. Imai K , Nakachi K . Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases . BMJ . 1995;310:693–696
  35. Vistisen K , Poulsen HE , Loft S . Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine . Carcinogenesis . 1992;13:1561–1568
  36. Jacobson KA , von Lubitz DK , Daly JW , Fredholm BB . Adenosine receptor ligands (differences with acute versus chronic treatment) . Trends Pharmacol Sci . 1996;17:108–113
  37. Day CP , James OF . Steatohepatitis (a tale of two “hits”?) . Gastroenterology . 1998;114:842–845
  38. Berson A, De Beco V, Letteron P, Robin MA, Moreau C, El Kahwaji J, et al. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes . Gastroenterology . 1998;114:764–774
  39. Devasagayam TP , Kamat JP , Mohan H , Kesavan PC . Caffeine as an antioxidant (inhibition of lipid peroxidation induced by reactive oxygen species) . Biochim Biophys Acta . 1996;1282:63–70
  40. Lee C . Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation . Clin Chim Acta . 2000;295:141–154
  41. Schilter B , Perrin I , Cavin C , Huggett AC . Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol . Carcinogenesis . 1996;17:2377–2384
  42. Urgert R , van der Weg G , Kosmeijer-Schuil TG , van de Bovenkamp P , Hovenier R , Katan MB . Levels of the cholesterol-elevating diterpenes cafestol and kahweol in various coffee brews . J Agric Food Chem . 1995;43:2167–2172
  43. Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ, et al. Coffee consumption and risk for type 2 diabetes mellitus . Ann Intern Med . 2004;140:1–8
  44. Tuomilehto J , Hu G , Bidel S , Lindstrom J , Jousilahti P . Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women . JAMA . 2004;291:1213–1219
  45. Hasegawa M , Yamada S , Hirayama C . Fasting plasma caffeine level in cirrhotic patients (relation to plasma levels of catecholamines and renin activity) . Hepatology . 1989;10:973–977
  46. Cheng WS , Murphy TL , Smith MT , Cooksley WG , Halliday JW , Powell LW . Dose-dependent pharmacokinetics of caffeine in humans (relevance as a test of quantitative liver function) . Clin Pharmacol Ther . 1990;47:516–524
  47. Ruhl CE , Everhart JE . Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States . Gastroenterology . 2003;124:1821–1829

 Supported by a contract from the National Institute of Diabetes and Digestive and Kidney Diseases (NO1-DK-1-2478).

PII: S0016-5085(04)01744-5

doi: 10.1053/j.gastro.2004.09.075

Gastroenterology
Volume 128, Issue 1 , Pages 24-32 , January 2005