Gastroenterology
Volume 127, Issue 6 , Pages 1695-1703 , December 2004

Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome

  • Charles D.R. Murray

      Affiliations

    • St Mark’s Hospital, Harrow, Middlesex, England
  • ,
  • Joanna Flynn

      Affiliations

    • Imperial College of Science, Technology and Medicine, London, England
  • ,
  • Laura Ratcliffe

      Affiliations

    • Imperial College of Science, Technology and Medicine, London, England
  • ,
  • Meron R. Jacyna

      Affiliations

    • Northwick Park Hospital, Harrow, Middlesex, England
  • ,
  • Michael A. Kamm

      Affiliations

    • St Mark’s Hospital, Harrow, Middlesex, England
  • ,
  • Anton V. Emmanuel

      Affiliations

    • St Mark’s Hospital, Harrow, Middlesex, England
    • Corresponding Author InformationAddress requests for reprints to: A. V. Emmanuel, MD, St Mark’s Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, England; fax: (44) 020 8235 4093

Received 27 May 2004 ,Accepted 19 August 2004.

References 

  1. Peveler R , Kilkenny L , Kinmonth AL . Medically unexplained physical symptoms in primary care (a comparison of self-report screening questionnaires and clinical opinion) . J Psychosom Res . 1997;42:245–252
  2. Stam R , Akkermans LM , Wiegant VM . Trauma and the gut (interactions between stressful experience and intestinal function) . Gut . 1997;40:704–709
  3. Kay L , Jorgensen T , Jensen KH . The epidemiology of irritable bowel syndrome in a random population (prevalence, incidence, natural history and risk factors) . J Intern Med . 1994;236:23–30
  4. Almy TP . Experimental studies on the irritable colon . Am J Med . 1951;10:60–67
  5. Welgan P , Meshkinpour H , Beeler M . Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome . Gastroenterology . 1988;94:1150–1156
  6. Stam R , Croiset G , Akkermans LM , Wiegant VM . Sensitization of the colonic response to novel stress after previous stressful experience . Am J Physiol . 1996;271:R1270–R1273
  7. Camilleri M , Coulie B , Tack JF . Visceral hypersensitivity (facts, speculations, and challenges) . Gut . 2001;48:125–131
  8. Mertz H , Naliboff B , Munakata J , Niazi N , Mayer EA . Altered rectal perception is a biological marker of patients with irritable bowel syndrome . Gastroenterology . 1995;109:40–52
  9. Ritchie J . Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome . Gut . 1973;14:125–132
  10. Dickhaus B, Mayer EA, Firooz N, Stains J, Conde F, Olivas TI, et al. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress . Am J Gastroenterol . 2003;98:135–143
  11. Galeazzi F, Luca MG, Lanaro D, D’Inca R, D’Odorico A, Sturniolo GC, et al. Esophageal hyperalgesia in patients with ulcerative colitis (role of experimental stress) . Am J Gastroenterol . 2001;96:2590–2595
  12. Phillips ML, Gregory LJ, Cullen S, Coen S, Ng V, Andrew C, et al. The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation . Brain . 2003;126:669–684
  13. Welgan P , Meshkinpour H , Ma L . Role of anger in antral motor activity in irritable bowel syndrome . Dig Dis Sci . 2000;45:248–251
  14. Erckenbrecht JF . Noise and intestinal motor alterations . In:  Bueno L ,  Collins S ,  Junien JL editor. Stress and digestive motility . Montrouge, France: John Libbey Eurotext; 2001;p. 93–96
  15. O’Brien JD , Thompson DG , Burnham WR , Holly J , Walker E . Action of centrally mediated autonomic stimulation on human upper gastrointestinal transit (a comparative study of two stimuli) . Gut . 1987;28:960–969
  16. Emmanuel AV , Kamm MA . Laser Doppler measurement of rectal mucosal blood flow . Gut . 1999;45:64–69
  17. Emmanuel AV , Kamm MA . Laser Doppler flowmetry as a measure of extrinsic colonic innervation in functional bowel disease . Gut . 2000;46:212–217
  18. Emmanuel AV , Mason HJ , Kamm MA . Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder . Gut . 2001;49:209–213
  19. Drossman DA , Corazziari E , Talley NJ , Thompson WG , Whitehead WE . Rome II. The functional gastrointestinal disorders. Diagnosis, pathophysiology and treatment: a multinational consensus . 2nd ed. McLean, VA: Degnon Associates Inc; 2000;
  20. Zigmond AS , Snaith RP . The hospital anxiety and depression scale . Acta Psychiatr Scand . 1983;67:361–370
  21. Bjelland I , Dahl AA , Haug TT , Neckelmann D . The validity of the Hospital Anxiety and Depression Scale. An updated literature review . J Psychosom Res . 2002;52:69–77
  22. Kamm MA , Lennard-Jones JE . Rectal mucosal electrosensory testing—evidence for a rectal sensory neuropathy in idiopathic constipation . Dis Colon Rectum . 1990;33:419–423
  23. Ford MJ , Camilleri M , Zinsmeister AR , Hanson RB . Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon . Gastroenterology . 1995;109:1772–1780
  24. Bouin M , Meunier P , Riberdy-Poitras M , Poitras P . Pain hypersensitivity in patients with functional gastrointestinal disorders (a gastrointestinal-specific defect or a general systemic condition?) . Dig Dis Sci . 2001;46:2542–2548
  25. Cook IJ , van Eeden A , Collins SM . Patients with irritable bowel syndrome have greater pain tolerance than normal subjects . Gastroenterology . 1987;93:727–733
  26. Verne GN , Robinson ME , Price DD . Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome . Pain . 2001;93:7–14
  27. Bennett EJ , Tennant CC , Piesse C , Badcock CA , Kellow JE . Level of chronic life stress predicts clinical outcome in irritable bowel syndrome . Gut . 1998;43:256–261
  28. Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ, et al. The role of psychological and biological factors in postinfective gut dysfunction . Gut . 1999;44:400–406
  29. Whitehead WE , Crowell MD , Robinson JC , Heller BR , Schuster MM . Effects of stressful life events on bowel symptoms (subjects with irritable bowel syndrome compared with subjects without bowel dysfunction) . Gut . 1992;33:825–830
  30. Rao SS , Hatfield RA , Suls JM , Chamberlain MJ . Psychological and physical stress induce differential effects on human colonic motility . Am J Gastroenterol . 1998;93:985–990
  31. Aggarwal A, Cutts TF, Abell TL, Cardoso S, Familoni B, Bremer J, et al. Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities . Gastroenterology . 1994;106:945–950

PII: S0016-5085(04)01559-8

doi: 10.1053/j.gastro.2004.08.057

Gastroenterology
Volume 127, Issue 6 , Pages 1695-1703 , December 2004