Gastroenterology
Volume 126, Issue 4 , Pages 1193-1195 , April 2004

Functional gastrointestinal disease: has the genomic era arrived?

  • Eamonn M.M. Quigley

      Affiliations

    • Department of Medicine, National University of Ireland, Cork, Ireland
    • Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    • Corresponding Author InformationAddress requests for reprints to: Eamonn M. M. Quigley, M.D., F.R.C.P., F.A.C.P., F.A.C.G., F.R.C.P.I., Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland fax: (353) 21 490 1289

References 

  1. Christensen J. The pathophysiology of the irritable bowel syndrome. Lancet. 1992;340:1444–1447
  2. Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE. Rome II, The functional gastrointestinal disorders. 2nd ed. McLean, Virginia: Degnon Associates; 2000;
  3. Fischler B, Tack J, De Gucht V, Shkedy ZI, Persoons P, Broekaert D, et al. Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia. Gastroenterology. 2003;124:903–910
  4. Dinan TG, Scott LV, Brady D, McNamara D, Keeling PWN. Altered hypothalamic cholinergic responses in patients with nonulcer dyspepsia (a study of pyridostigmine-stimulated growth hormone release). Am J Gastroenterol. 2002;97:1937–1940
  5. Tack J, Demedts I, Dehondt G, Caenepeel P, Fischler B, Zandecki M, et al. Clinical and pathophysiogical characterisitics of acute-onset functional dyspepsia. Gastroenterology. 2002;122:1738–1747
  6. Spiller RC. Estimating the importance of infection in IBS. Am J Gastroenterol. 2003;98:238–241
  7. Dunlop SP, Jenkins D, Neal KR, Spiller RC. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology. 2003;125:1651–1659
  8. Chadwick VS, Chen W, Shu D, Paulus B, Bethwaite P, Tie A, et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology. 2002;122:1778–1783
  9. Tornblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology. 2002;123:1972–1979
  10. Collins SM. A case for an immunological basis for irritable bowel syndrome. Gastroenterology. 2002;122:2078–2080
  11. Collins SM. Stress and the gastrointestinal tract IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance. Am J Physiol. 2001;280:G315–G318
  12. Mayer EA, Collins SM. Evolving pathophysiological models of functional gastrointestinal disorders. Gastroenterology. 2002;122:2032–2048
  13. Spiller RC. Role of nerves in enteric infection. Gut. 2002;51:759–762
  14. Locke GR, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc. 2000;75:907–912
  15. Morris-Yates A, Talley NJ, Boyce PM, Nandurkar S, Andrews G. Evidence for a genetic contribution to functional bowel disorder. Am J Gastroenterol. 1998;93:1311–1317
  16. Levy RL, Jones KR, Whitehead WE, Feld SI, Talley NJ, Corey LA. Irritable bowel syndrome in twins (heredity and social learning both contribute to etiology). Gastroenterology. 2001;121:799–804
  17. Holtmann G, Siffert W, Haag S, Mueller N, Langkafel M, Senf W, et al. G-protein β3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology. 2004;126:971–979
  18. Locke GR. Prevalence, incidence and natural history of dyspepsia and functional dyspepsia. Baillieres Clin Gastroenterol. 1998;12:435–442
  19. Locke GR. Natural history of irritable bowel syndrome and durability of the diagnosis. Rev Gastroenterol Disord. 2003;3(Suppl. 3):S12–S17
  20. Ioannidis JPA, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG. Genetic associations in large versus small studies (an empirical assessment). Lancet. 2003;361:567–571
  21. Cardon LR, Plamer LJ. Population stratification and spurious allelic association. Lancet. 2003;361:598–604
  22. Colhoun HM, McKeigue PM, Davey-Smith G. Problems of reporting genetic associations with complex outcomes. Lancet. 2003;361:865–872

☆ Supported by grants from Science Foundation Ireland.

PII: S0016-5085(04)00301-4

doi: 10.1053/j.gastro.2004.02.028

Gastroenterology
Volume 126, Issue 4 , Pages 1193-1195 , April 2004

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