Gastroenterology
Volume 127, Issue 1 , Pages 294-299, July 2004

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient☆

  • Elena Tamborini

      Affiliations

    • Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Lorena Bonadiman

      Affiliations

    • Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Angela Greco

      Affiliations

    • Department of Experimental Oncology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Veronica Albertini

      Affiliations

    • Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Tiziana Negri

      Affiliations

    • Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Alessandro Gronchi

      Affiliations

    • Department of Head and Neck and Soft Tissue Surgery, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Rossella Bertulli

      Affiliations

    • Department of Radiotherapy, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Maurizio Colecchia

      Affiliations

    • Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • ,
  • Paolo G. Casali

      Affiliations

    • Department of Head and Neck and Soft Tissue Surgery, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • P.G.C., M.A.P., and S.P. are senior coauthors.
    • ,
  • Marco A. Pierotti

      Affiliations

    • Department of Experimental Oncology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • Fondazione Italiana Ricerca sul Cancro, Institute of Molecular Oncology, Milan, Italy
    • P.G.C., M.A.P., and S.P. are senior coauthors.
    • ,
  • Silvana Pilotti

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Silvana Pilotti, M.D., Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, via G. Venezian, 1, 20133 Milan, Italy, fax: (39) 02-23902756
    • Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    • P.G.C., M.A.P., and S.P. are senior coauthors.

Received 16 October 2003; accepted 12 February 2004.

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☆ Supported by grants from Ministero della Sanitá, Ricerca Finalizzata 2001 Italy, and Associazione Italiana per la Ricerca sul Cancro (grant no. 420.198.122).

PII: S0016-5085(04)00220-3

doi:10.1053/j.gastro.2004.02.021

Gastroenterology
Volume 127, Issue 1 , Pages 294-299, July 2004

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