Gastroenterology
Volume 127, Issue 1 , Pages 300-309, July 2004

Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease

  • Janine Bilsborough

      Affiliations

    • Department of Autoimmunity and Vascular Biology, Amgen, Seattle, Washington, USA
    • Dr. Bilsborough’s current address is: Zymogenetics, 1201 Eastlake Avenue E, Seattle, Washington 98102.
    • ,
  • Joanne L. Viney

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Joanne L. Viney, M.D., Amgen, 51 University Street, Seattle, Washington 98101, USA, fax: (206) 217-0494
    • Department of Autoimmunity and Vascular Biology, Amgen, Seattle, Washington, USA

Received 21 November 2003; accepted 22 January 2004.

Abstract 

Discrimination between beneficial commensal organisms and potentially harmful pathogens is a central component of the essential role that gut immune cells play in maintaining the balance between immune activation and tolerance. Antigen presenting cells (APC) are the key to this process, and the type of APC, including epithelial cells, B cells, macrophages, and dendritic cells (DC), in the gut is varied. The purpose of this review is to focus on the vast amount of data that has recently been generated on gastrointestinal dendritic cells in the context of their potential function and contribution to mucosal immunity, tolerance, and disease.

Abbreviations:  APC, antigen presenting cells, DC, dendritic cells, MLN, mesenteric lymph nodes, PLN, peripheral lymph nodes

 

PII: S0016-5085(04)00102-7

doi:10.1053/j.gastro.2004.01.028

Gastroenterology
Volume 127, Issue 1 , Pages 300-309, July 2004

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